Sulfite (PAMDB000100)

General function:

Involved in thiosulfate sulfurtransferase activity

Specific function:

Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide. The relatively low affinity of glpE for both thiosulfate and cyanide suggests that these compounds are not the physiological substrates. Thioredoxin 1 or related dithiol proteins could instead be the physiological sulfur-acceptor substrate. Possible association with the metabolism of glycerol-phosphate remains to be elucidated

Gene Name:

glpE

Locus Tag:

PA0589

Molecular weight:

12 kDa

Reactions

General function:

Involved in cysteine biosynthetic process from serine

Specific function:

O(3)-acetyl-L-serine + H(2)S = L-cysteine + acetate

Gene Name:

cysK

Locus Tag:

PA2709

Molecular weight:

34.3 kDa

Reactions

General function:

Involved in cysteine biosynthetic process from serine

Specific function:

Two cysteine synthase enzymes are found. Both catalyze the same reaction. Cysteine synthase B can also use thiosulfate in place of sulfide to give cysteine thiosulfonate as a product

Gene Name:

cysM

Locus Tag:

PA0932

Molecular weight:

32.4 kDa

Reactions

General function:

Involved in sulfite reductase (NADPH) activity

Specific function:

Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate

Gene Name:

cysI

Locus Tag:

PA1838

Molecular weight:

62.1 kDa

Reactions

General function:

Involved in phosphoadenylyl-sulfate reductase (thioredoxin) activity

Specific function:

Reduction of activated sulfate into sulfite

Gene Name:

cysH

Locus Tag:

PA1756

Molecular weight:

30.2 kDa

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Catalyzes the conversion of taurine and alpha ketoglutarate to sulfite, aminoacetaldehyde and succinate. Required for the utilization of taurine (2-aminoethanesulfonic acid) as an alternative sulfur source. Pentane-sulfonic acid, 3- (N-morpholino)propanesulfonic acid and 1,3-dioxo-2- isoindolineethanesulfonic acid are also substrates for this enzyme

Gene Name:

tauD

Locus Tag:

PA3935

Molecular weight:

31 kDa

Reactions

General function:

Involved in FMN reductase activity

Specific function:

Catalyzes an NAD(P)H-dependent reduction of FMN, but is also able to reduce FAD or riboflavin

Gene Name:

ssuE

Locus Tag:

PA3446

Molecular weight:

21.5 kDa

Reactions

General function:

Involved in alkanesulfonate monooxygenase activity

Specific function:

Involved in desulfonation of aliphatic sulfonates. Catalyzes the conversion of pentanesulfonic acid to sulfite and pentaldehyde and is able to desulfonate a wide range of sulfonated substrates including C-2 to C-10 unsubstituted linear alkanesulfonates, substituted ethanesulfonic acids and sulfonated buffers

Gene Name:

ssuD

Locus Tag:

PA3444

Molecular weight:

41.6 kDa

Reactions

General function:

Involved in transporter activity

Specific function:

Part of a binding-protein-dependent transport system for aliphatic sulfonates. Probably responsible for the translocation of the substrate across the membrane

Gene Name:

ssuC

Locus Tag:

PA3443

Molecular weight:

28.5 kDa

General function:

Involved in electron carrier activity

Specific function:

Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters (Probable)

Gene Name:

grxD

Locus Tag:

PA3533

Molecular weight:

11.8 kDa

General function:

Involved in electron carrier activity

Specific function:

The disulfide bond functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase. In addition, it is also involved in reducing some disulfides in a coupled system with glutathione reductase

Gene Name:

grxC

Locus Tag:

PA5129

Molecular weight:

9.2 kDa

General function:

Involved in electron carrier activity

Specific function:

Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions

Gene Name:

trxA

Locus Tag:

PA5240

Molecular weight:

11.9 kDa