Cysteine synthase A (PA2709)

Identification
Name: Cysteine synthase A
Synonyms:
  • CSase A
  • O-acetylserine (thiol)-lyase A
  • OAS-TL A
  • O-acetylserine sulfhydrylase A
  • Sulfate starvation-induced protein 5
  • SSI5
Gene Name: cysK
Enzyme Class:
Biological Properties
General Function: Involved in cysteine biosynthetic process from serine
Specific Function: O(3)-acetyl-L-serine + H(2)S = L-cysteine + acetate
Cellular Location: Not Available
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb ↔ Thumb+Thumb+Thumb
O-Acetylserine + Hydrogen sulfide ↔ Acetic acid + L-Cysteine + Hydrogen ion
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Thumb+Thumb ↔ Thumb+Thumb
O-Acetylserine + Hydrogen sulfide ↔ L-Cysteine + Acetic acid
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Thumb+Thumb ↔ Thumb+Thumb
O-Acetylserine + Hydrogen selenide ↔ Selenocysteine + Acetic acid
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Thumb+Thumb+Thioredoxin+Thumb ↔ Thumb+Thumb+Thioredoxin disulfide+Thumb
O-Acetylserine + Thiosulfate + Thioredoxin + Hydrogen ion ↔ L-Cysteine + Sulfite + Thioredoxin disulfide + Acetic acid
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SMPDB Reactions:
Thumb+Thumb → Thumb+Thumb+Thumb
O-Acetylserine + Hydrogen sulfide → Hydrogen ion + Acetic acid + L-Cysteine
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Thumb+Thumb ↔ Thumb+Thumb+Thumb
Hydrogen sulfide + O-Acetylserine ↔ L-Cysteine + Acetic acid + Hydrogen ion
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Thumb → Thumb+Thumb+Thumb
L-Cysteine → Hydrogen ion + Hydrogen sulfide + 2-Aminoacrylic acid
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PseudoCyc/BioCyc Reactions:
Thumb+Thumb ↔ Thumb+Thumb+Thumb
O-Acetylserine + Hydrogen sulfide ↔ Acetic acid + L-Cysteine + Hydrogen ion
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Complex Reactions:
Thumb+Thumb → Thumb+Thumb
O-Acetylserine + Hydrogen sulfide → L-Cysteine + Acetic acid
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Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB0005192-Aminoacrylic acidMetaboCard
PAMDB000012Acetic acidMetaboCard
PAMDB000573ChlorideMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB000804Hydrogen selenideMetaboCard
PAMDB000486Hydrogen sulfideMetaboCard
PAMDB000152L-CysteineMetaboCard
PAMDB000473O-AcetylserineMetaboCard
PAMDB003492S-Carboxymethyl-L-cysteineMetaboCard
PAMDB000488SelenocysteineMetaboCard
PAMDB000100SulfiteMetaboCard
PAMDB001967ThioglycolateMetaboCard
PAMDB004174ThioredoxinMetaboCard
PAMDB000108ThiosulfateMetaboCard
GO Classification:
Function
binding
carbon-oxygen lyase activity
catalytic activity
cofactor binding
cysteine synthase activity
lyase activity
pyridoxal phosphate binding
Process
cellular amino acid and derivative metabolic process
cellular amino acid metabolic process
cellular metabolic process
cysteine biosynthetic process from serine
L-serine metabolic process
metabolic process
serine family amino acid metabolic process
Gene Properties
Locus tag: PA2709
Strand: +
Entrez Gene ID: 882613
Accession: NP_251399.1
GI: 15597905
Sequence start: 3062939
Sequence End: 3063913
Sequence Length: 974
Gene Sequence: 
>PA2709
ATGAGCCGCATCTTCGCAGACAACGCGCAGTCCATCGGCAACACGCCGCTGGTCCAGATCAACCGCATCGCCCCGCGCGGCGTCACCATCCTGGCCAAGATCGAAGGGCGCAACCCCGGCTATTCGGTGAAGTGCCGGATCGGCGCGAACATGATCTGGGATGCCGAAGCCAGCGGCAGACTGAAGTCCGGCATGACCCTGGTCGAGCCGACCTCCGGCAACACCGGCATCGGCCTCGCCTTCGTCGCCGCCGCACGCGGCTACAAACTGATCCTGACCATGCCGGCGTCGATGAGCCTGGAGCGACGCAAGGTGCTCAAGGCGCTGGGCGCGGAGCTGGTCCTGACCGAACCGGCGAAGGGCATGAAGGGTGCGATCCAGAAGGCCGAGGAACTGGTCGCGGGGGATCCCGGGAAGTACTTCATGCCGCAGCAGTTCGACAACCCGGCCAACCCGGCGATCCATGAGAAGACCACCGGCCCGGAGATCTGGAACGATACCGAGGGCGCGGTGGACGTGCTGGTCTCCGGGGTCGGCACCGGCGGCACCCTCACCGGCGTCTCGCGCTACATCAAGAACACCCGGGGCAAGCCGATCCTCGCCGTGGCGGTGGAGCCGGTGACCTCGCCGGTGATCAGCCAGACCCTCGCCGGCGAGGAGGTCAAGCCCGCCCCGCACAAGATCCAGGGCATCGGCGCCGGCTTCGTGCCGAAGAACCTCGACCTGTCGCTGGTCGACCGGGTCGAGAAGATCGGCGACGACGAAGCGAAGAACATGGCGCTGCGCCTGATGCAGGAAGAAGGCATCCTCTGCGGCATCTCCTCCGGCGCGGCGATGGCCGCCGCGGTGCGCCTGGCCGAGGAGCCGAACATGCAGGGCAAGACCATCGTGGTGATCCTCCCCGATTCCGGCGAGCGCTATCTTTCGAGCATGCTCTTCGACGGCCTGTTCAGCGAACAGGAACTGACCCAGTAA
Protein Properties
Protein Residues: 324
Protein Molecular Weight: 34.3 kDa
Protein Theoretical pI: 6.56
Hydropathicity (GRAVY score): -0.037
Charge at pH 7 (predicted): -0.57
Protein Sequence: 
>PA2709
MSRIFADNAQSIGNTPLVQINRIAPRGVTILAKIEGRNPGYSVKCRIGANMIWDAEASGRLKSGMTLVEPTSGNTGIGLAFVAAARGYKLILTMPASMSLERRKVLKALGAELVLTEPAKGMKGAIQKAEELVAGDPGKYFMPQQFDNPANPAIHEKTTGPEIWNDTEGAVDVLVSGVGTGGTLTGVSRYIKNTRGKPILAVAVEPVTSPVISQTLAGEEVKPAPHKIQGIGAGFVPKNLDLSLVDRVEKIGDDEAKNMALRLMQEEGILCGISSGAAMAAAVRLAEEPNMQGKTIVVILPDSGERYLSSMLFDGLFSEQELTQ
References
External Links:
Resource Link
Genome ID: PA2709
Entrez Gene ID: 882613
NCBI Protein ID: 15597905
General Reference: PaperBLAST - Find papers about PA2709 and its homologs