Phosphoadenosine phosphosulfate reductase (PA1756)

Identification
Name: Phosphoadenosine phosphosulfate reductase
Synonyms:
  • 3'-phosphoadenylylsulfate reductase
  • PAPS reductase, thioredoxin dependent
  • PAPS sulfotransferase
  • PAdoPS reductase
Gene Name: cysH
Enzyme Class:
Biological Properties
General Function: Involved in phosphoadenylyl-sulfate reductase (thioredoxin) activity
Specific Function: Reduction of activated sulfate into sulfite
Cellular Location: Cytoplasm
KEGG Pathways:
KEGG Reactions:
Thioredoxin+Thumb+Thioredoxin disulfide ↔ Thioredoxin disulfide+Thumb+Thumb+Thumb
Thioredoxin + Phosphoadenosine phosphosulfate + Thioredoxin disulfide ↔ Thioredoxin disulfide + Sulfite + Adenosine 3',5'-diphosphate + Thioredoxin
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SMPDB Reactions:
Thumb+reduced thioredoxin → Sulfite+2 Thumb+Adenosine 3',5'-diphosphate+2 oxidized thioredoxin +Thumb+Thumb
Phosphoadenosine phosphosulfate + reduced thioredoxin → Sulfite + 2 Hydrogen ion + Adenosine 3',5'-diphosphate + 2 oxidized thioredoxin + Sulfite + Adenosine 3',5'-diphosphate
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Thumb+reduced thioredoxin → Sulfite+oxidized thioredoxin +Thumb+Adenosine 3',5'-diphosphate+Thumb+Thumb
Phosphoadenosine phosphosulfate + reduced thioredoxin → Sulfite + oxidized thioredoxin + Hydrogen ion + Adenosine 3',5'-diphosphate + Sulfite + Adenosine 3',5'-diphosphate
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PseudoCyc/BioCyc Reactions:
Thioredoxin+Thumb+Thioredoxin disulfide ↔ Thioredoxin disulfide+Thumb+Thumb+Thumb
Thioredoxin + Phosphoadenosine phosphosulfate + Thioredoxin disulfide ↔ Thioredoxin disulfide + Sulfite + Adenosine 3',5'-diphosphate + Thioredoxin
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Thumb+Thumb+thioredoxin disulfide → Thumb+thioredoxin
Adenosine 3',5'-diphosphate + Sulfite + thioredoxin disulfide → Phosphoadenosine phosphosulfate + thioredoxin
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Thumb+reduced thioredoxin → Sulfite+2 Thumb+Adenosine 3',5'-diphosphate+2 oxidized thioredoxin +Thumb+Thumb
Phosphoadenosine phosphosulfate + reduced thioredoxin → Sulfite + 2 Hydrogen ion + Adenosine 3',5'-diphosphate + 2 oxidized thioredoxin + Sulfite + Adenosine 3',5'-diphosphate
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Thumb+reduced thioredoxin → Sulfite+oxidized thioredoxin +Thumb+Adenosine 3',5'-diphosphate+Thumb+Thumb
Phosphoadenosine phosphosulfate + reduced thioredoxin → Sulfite + oxidized thioredoxin + Hydrogen ion + Adenosine 3',5'-diphosphate + Sulfite + Adenosine 3',5'-diphosphate
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Thumb
3'-phosphoadenylyl-sulfate + NADPH → adenosine 3',5'-bisphosphate + sulfite + NADP+ + H+
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PAMDB110213+PAMDB000100+PAMDB001633 → PAMDB110212
adenosine 3',5'-bisphosphate + Sulfite + Hydrogen ion → 3'-phosphoadenylyl-sulfate
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Complex Reactions:
glutaredoxin+Thumb → glutaredoxin+2 Thumb+Thumb+Thumb
glutaredoxin + Phosphoadenosine phosphosulfate → glutaredoxin + 2 Hydrogen ion + Adenosine 3',5'-diphosphate + Sulfite
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Thumb+Reduced Thioredoxin → 2 Thumb+Thumb+Thumb+Oxidized Thioredoxin
Phosphoadenosine phosphosulfate + Reduced Thioredoxin → 2 Hydrogen ion + Adenosine 3',5'-diphosphate + Sulfite + Oxidized Thioredoxin
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Thumb+Thumb+thioredoxin disulfide → Thumb+thioredoxin
Adenosine 3',5'-diphosphate + Sulfite + thioredoxin disulfide → Phosphoadenosine phosphosulfate + thioredoxin
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Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB000022Adenosine 3',5'-diphosphateMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB000269Phosphoadenosine phosphosulfateMetaboCard
PAMDB000100SulfiteMetaboCard
PAMDB004174ThioredoxinMetaboCard
GO Classification:
Function
catalytic activity
oxidoreductase activity
oxidoreductase activity, acting on a sulfur group of donors
oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor
phosphoadenylyl-sulfate reductase (thioredoxin) activity
Process
cellular amino acid and derivative metabolic process
cellular amino acid metabolic process
cellular metabolic process
cysteine biosynthetic process
metabolic process
oxidation reduction
sulfate assimilation
sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)
sulfur amino acid biosynthetic process
sulfur amino acid metabolic process
sulfur metabolic process
Gene Properties
Locus tag: PA1756
Strand: -
Entrez Gene ID: 878560
Accession: NP_250447.1
GI: 15596953
Sequence start: 1895692
Sequence End: 1896495
Sequence Length: 803
Gene Sequence: 
>PA1756
ATGCTGCCCTTTGCTACCATTCCCGCCACAGAGCGCAACAGCGCCGCCCAGCACCAGGACCCCAGCCCGATGAGCCAGCCTTTCGACCTTCCCGCCCTCGCCTCCAGCCTTGCCGACAAATCCCCCCAGGACATCCTGAAAGCCGCCTTCGAGCACTTCGGCGACGAGCTGTGGATCTCCTTCAGCGGCGCCGAGGACGTCGTCCTGGTAGACATGGCCTGGAAGCTCAACCGCAACGTGAAGGTGTTCAGCCTCGACACCGGTCGCCTGCACCCGGAAACCTATCGTTTCATCGACCAGGTCCGCGAACACTACGGCATCGCCATCGACGTGCTTTCCCCCGACCCGCGCCTGCTCGAACCCCTGGTGAAGGAAAAGGGCCTGTTCAGCTTCTACCGGGACGGCCACGGCGAGTGCTGCGGCATCCGCAAGATCGAACCGCTCAAGCGCAAGCTCGCCGGTGTGCGCGCCTGGGCCACCGGCCAACGCCGCGACCAGAGCCCCGGCACGCGCAGCCAGGTGGCAGTGCTGGAAATCGACGGTGCCTTTTCCACGCCGGAAAAGCCGCTGTACAAGTTCAACCCGCTGTCGTCCATGACCAGCGAGGAAGTCTGGGGCTATATCCGCATGCTCGAACTGCCCTACAACAGCCTGCACGAACGCGGCTATATCAGCATCGGCTGCGAACCCTGCACCCGTCCGGTGCTGCCCAACCAGCACGAGCGCGAGGGCCGCTGGTGGTGGGAGGAAGCCACCCACAAGGAGTGCGGGCTGCACGCCGGCAACCTGATCAGCAAGGCCTGA
Protein Properties
Protein Residues: 267
Protein Molecular Weight: 30.2 kDa
Protein Theoretical pI: 6.42
Hydropathicity (GRAVY score): -0.447
Charge at pH 7 (predicted): -2.98
Protein Sequence: 
>PA1756
MLPFATIPATERNSAAQHQDPSPMSQPFDLPALASSLADKSPQDILKAAFEHFGDELWISFSGAEDVVLVDMAWKLNRNVKVFSLDTGRLHPETYRFIDQVREHYGIAIDVLSPDPRLLEPLVKEKGLFSFYRDGHGECCGIRKIEPLKRKLAGVRAWATGQRRDQSPGTRSQVAVLEIDGAFSTPEKPLYKFNPLSSMTSEEVWGYIRMLELPYNSLHERGYISIGCEPCTRPVLPNQHEREGRWWWEEATHKECGLHAGNLISKA
References
External Links:
Resource Link
Genome ID: PA1756
Entrez Gene ID: 878560
NCBI Protein ID: 15596953
General Reference: PaperBLAST - Find papers about PA1756 and its homologs