Cysteine synthase B (PA0932)

Identification
Name: Cysteine synthase B
Synonyms:
  • CSase B
  • O-acetylserine (thiol)-lyase B
  • OAS-TL B
  • O-acetylserine sulfhydrylase B
Gene Name: cysM
Enzyme Class:
Biological Properties
General Function: Involved in cysteine biosynthetic process from serine
Specific Function: Two cysteine synthase enzymes are found. Both catalyze the same reaction. Cysteine synthase B can also use thiosulfate in place of sulfide to give cysteine thiosulfonate as a product
Cellular Location: Not Available
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb ↔ Thumb+Thumb+Thumb
O-Acetylserine + Hydrogen sulfide ↔ Acetic acid + L-Cysteine + Hydrogen ion
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Thumb+Thumb ↔ Thumb+Thumb
O-Acetylserine + Hydrogen sulfide ↔ L-Cysteine + Acetic acid
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Thumb+Thumb ↔ Thumb+Thumb
O-Acetylserine + Thiosulfate ↔ Cysteine-S-sulfate + Acetic acid
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Thumb+Thumb ↔ Thumb+Thumb
O-Acetylserine + Hydrogen selenide ↔ Selenocysteine + Acetic acid
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Thumb+Thumb+Thioredoxin+Thumb ↔ Thumb+Thumb+Thioredoxin disulfide+Thumb
O-Acetylserine + Thiosulfate + Thioredoxin + Hydrogen ion ↔ L-Cysteine + Sulfite + Thioredoxin disulfide + Acetic acid
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SMPDB Reactions:
Thumb → Thumb+Thumb+Thumb
O-Acetylserine → Hydrogen ion + Acetic acid + L-Cysteine
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Thumb+Thumb → Thumb+Thumb+Thumb
O-Acetylserine + Hydrogen sulfide → Hydrogen ion + Acetic acid + L-Cysteine
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Thumb+Thumb ↔ Thumb+Thumb+Thumb
Hydrogen sulfide + O-Acetylserine ↔ L-Cysteine + Acetic acid + Hydrogen ion
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Thumb → Thumb+Thumb+Thumb
L-Cysteine → Hydrogen ion + Hydrogen sulfide + 2-Aminoacrylic acid
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Thumb+Thiosulfate+Thumb → Thumb+Thumb
O-Acetylserine + Thiosulfate + Thiosulfate → Cysteine-S-sulfate + Acetic acid
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PseudoCyc/BioCyc Reactions:
Thumb+Thumb ↔ Thumb+Thumb+Thumb
O-Acetylserine + Hydrogen sulfide ↔ Acetic acid + L-Cysteine + Hydrogen ion
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Complex Reactions:
Thumb+Thumb → Thumb+Thumb
O-Acetylserine + Hydrogen sulfide → L-Cysteine + Acetic acid
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Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB0005192-Aminoacrylic acidMetaboCard
PAMDB000012Acetic acidMetaboCard
PAMDB000180Cysteine-S-sulfateMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB000804Hydrogen selenideMetaboCard
PAMDB000486Hydrogen sulfideMetaboCard
PAMDB000152L-CysteineMetaboCard
PAMDB000473O-AcetylserineMetaboCard
PAMDB000488SelenocysteineMetaboCard
PAMDB000100SulfiteMetaboCard
PAMDB004174ThioredoxinMetaboCard
PAMDB000108ThiosulfateMetaboCard
GO Classification:
Function
binding
carbon-oxygen lyase activity
catalytic activity
cofactor binding
cysteine synthase activity
lyase activity
pyridoxal phosphate binding
Process
cellular amino acid and derivative metabolic process
cellular amino acid metabolic process
cellular metabolic process
cysteine biosynthetic process from serine
L-serine metabolic process
metabolic process
serine family amino acid metabolic process
Gene Properties
Locus tag: PA0932
Strand: +
Entrez Gene ID: 881832
Accession: NP_249623.1
GI: 15596129
Sequence start: 1020708
Sequence End: 1021607
Sequence Length: 899
Gene Sequence: 
>PA0932
ATGACCGTGCAGTACCCGACTATCGCCGACTGCGTTGGCAATACCCCTCTGGTGCGTCTGCAGCGCCTTCCCGGGGAAACCTCCAATACCCTGCTGGTGAAGCTCGAAGGCAACAACCCGGCGGGATCGGTGAAGGACCGCCCGGCCCTGTCGATGATCACCCGTGCCGAACTGCGCGGCGACATCCGCCCCGGCGATACGCTGATCGAGGCTACTTCCGGCAACACCGGCATCGCCCTGGCCATGGCGGCGGCGATCAAGGGTTACAAGATGATCCTGATCATGCCGGACAACTCCACGGCCGAACGCAAGGCGGCGATGACCGCCTATGGCGCCGAGCTCATTCTGGTCAGCAAGGAAGAGGGCATGGAGGGCGCGCGCGATCTGGCCGACAAGCTGCAGCGCGAAGGCCGCGGCAAGGTCCTCGACCAGTTCGCCAATGGCGACAACCCGGAAGCCCATTACCACAGCACCGGCCCGGAAATCTGGCAGCAGACCGGCGGCAGCATCACCCATTTCGTCAGCTCCATGGGCACCACCGGGACCATCATGGGCGTCTCGCGCTACCTCAAGGAGCAGAACCCGGCGGTGCAGATCGTCGGCCTGCAACCCATGGAGGGCTCGGCCATCCCGGGAATCCGACGCTGGCCGCAGGAATACCTGCCGAAGATCTATGACGCCAGTCGCGTCGACCGGGTCGTCGACATGCACCAGGACGAAGCCGAGGACATCATGCGCCGGCTGGCCCGCGAGGAAGGCATCTTCTGCGGCGTGTCCTCCGGTGGGGCGGTGGCGGCGATGCTGCGCCTGTCCCGCGAACTGGAGAATGCCGTGCTGGTGGCGATCATCTGCGACCGCGGCGACCGCTACCTGTCTTCCGGCGTCTATGACCCGCGCTGA
Protein Properties
Protein Residues: 299
Protein Molecular Weight: 32.4 kDa
Protein Theoretical pI: 5.46
Hydropathicity (GRAVY score): -0.268
Charge at pH 7 (predicted): -4.12
Protein Sequence: 
>PA0932
MTVQYPTIADCVGNTPLVRLQRLPGETSNTLLVKLEGNNPAGSVKDRPALSMITRAELRGDIRPGDTLIEATSGNTGIALAMAAAIKGYKMILIMPDNSTAERKAAMTAYGAELILVSKEEGMEGARDLADKLQREGRGKVLDQFANGDNPEAHYHSTGPEIWQQTGGSITHFVSSMGTTGTIMGVSRYLKEQNPAVQIVGLQPMEGSAIPGIRRWPQEYLPKIYDASRVDRVVDMHQDEAEDIMRRLAREEGIFCGVSSGGAVAAMLRLSRELENAVLVAIICDRGDRYLSSGVYDPR
References
External Links:
Resource Link
Genome ID: PA0932
Entrez Gene ID: 881832
NCBI Protein ID: 15596129
General Reference: PaperBLAST - Find papers about PA0932 and its homologs