Acetolactate synthase isozyme 3 large subunit (PA4696)

Identification
Name: Acetolactate synthase isozyme 3 large subunit
Synonyms:
  • AHAS-III
  • ALS-III
  • Acetohydroxy-acid synthase III large subunit
Gene Name: ilvI
Enzyme Class:
Biological Properties
General Function: Involved in magnesium ion binding
Specific Function: 2 pyruvate = 2-acetolactate + CO(2)
Cellular Location: Not Available
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb+Thumb → Thumb+Thumb
2-Ketobutyric acid + Hydrogen ion + Pyruvic acid → 2-Aceto-2-hydroxy-butyrate + Carbon dioxide
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Thumb+2 Thumb → Thumb+Thumb
Hydrogen ion + 2 Pyruvic acid → (S)-2-Acetolactate + Carbon dioxide
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Thumb+Thumb ↔ 2 Thumb
2-Acetolactate + Carbon dioxide ↔ 2 Pyruvic acid
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Thumb+Thumb ↔ 2 Thumb
(S)-2-Acetolactate + Carbon dioxide ↔ 2 Pyruvic acid
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SMPDB Reactions:
2 Thumb+Thumb → Thumb+Thumb
2 Pyruvic acid + Hydrogen ion → Carbon dioxide + (S)-2-Acetolactate
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Thumb+Thumb+Thumb → Thumb+Thumb
2-Ketobutyric acid + Hydrogen ion + Pyruvic acid → Carbon dioxide + 2-Aceto-2-hydroxy-butyrate
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Thumb → Thumb+Thumb
Pyruvic acid → Carbon dioxide + 2-Acetolactate
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PseudoCyc/BioCyc Reactions:
Thumb+Thumb+Thumb → Thumb+Thumb
2-Ketobutyric acid + Hydrogen ion + Pyruvic acid → 2-Aceto-2-hydroxy-butyrate + Carbon dioxide
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Complex Reactions:
2 Thumb → Thumb+Thumb
2 Pyruvic acid → 2-Acetolactate + Carbon dioxide
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Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB000697(S)-2-AcetolactateMetaboCard
PAMDB0005492-Aceto-2-hydroxy-butyrateMetaboCard
PAMDB0005502-AcetolactateMetaboCard
PAMDB0000012-Ketobutyric acidMetaboCard
PAMDB000568Carbon dioxideMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB000102Pyruvic acidMetaboCard
PAMDB000361Thiamine pyrophosphateMetaboCard
GO Classification:
Function
acetolactate synthase activity
adenyl nucleotide binding
binding
catalytic activity
cation binding
FAD or FADH2 binding
ion binding
magnesium ion binding
metal ion binding
nucleoside binding
purine nucleoside binding
thiamin pyrophosphate binding
transferase activity
transferase activity, transferring aldehyde or ketonic groups
vitamin binding
Process
branched chain family amino acid biosynthetic process
cellular amino acid and derivative metabolic process
cellular amino acid biosynthetic process
cellular amino acid metabolic process
cellular metabolic process
metabolic process
Gene Properties
Locus tag: PA4696
Strand: -
Entrez Gene ID: 881496
Accession: NP_253384.1
GI: 15599890
Sequence start: 5274008
Sequence End: 5275732
Sequence Length: 1724
Gene Sequence: 
>PA4696
GTGGAGCTTTTATCTGGCGCTGAAATGGTCGTCCGCTCGTTGCGCGACGAAGGCGTTAAGTACATCTACGGGTACCCGGGTGGTGCCCTCCTGCATATCTACGACGCGCTCTTCAAGGAGCACGACGTGACCCACATCCTGGTGCGCCACGAACAGGCGGCTACCCATATGGCCGACGGCTACGCCCGCGCCACCGGCAAGCCCGGTGTCGTGCTGGTGACTTCCGGCCCGGGCGCGACCAACGCCATCACCGGTATCGCCACCGCATACATGGACTCCATCCCGATGGTGATCCTGTCGGGCCAGGTGCCGAGCAACATGGTCGGTACCGATGCGTTCCAGGAAACCGACATGGTCGGGATCTCCCGGCCGATCGTGAAGCACAGCTTCATCATCAAGCATCCCTCGGAAATTCCCGAGGTGATCAAGAAGGCCTTCTACCTGGCGCAGTCCGGTCGTCCGGGGCCGGTGGTCGTGGATATTCCGAAGGACATGGGCGACCCGACGCAGAAATTCGAATATTCCTATCCGAAGAAGGTCAAGTTGCGTTCGTACAGCCCGGCCGTTCGCGGTCACTCGGGACAGATCCGCAAGGCCGCCGAGATGCTCCTGGCCGCCAAGCGCCCGGTGGTCTATTCCGGCGGCGGCGTGATCATGGGCAATGCCGCGGCGCCGCTGACCGAGCTGGCGCAGATGCTCAACCTGCCGGTGACCAACACCCTGATGGGCCTCGGCGGGTATCCCGGCGCAGACCGCCAGTTCCTCGGCATGCTCGGGATGCATGGCAGCTTCACCGCCAACCTGGCGATGCATCACAGCGACGTGATCCTCGCGGTCGGCGCGCGTTTCGACGACCGGGTCATCAACGGTGCGGCGAAGTTCTGCCCGAACGCCAAGATCATCCACATCGACATCGATCCGGCGTCGATTTCCAAGACCATCAAGGCCGACATCCCGATCGTCGGCCCGGTGGACAGCGTTCTCACCGAAATGGTCGCGATCGTCAGGGAAATCGGCGAGACCCCGAACCAGGATGCCCAGGCTGCCTGGTGGAAGCAGATCGACGAGTGGCGTGGTAACCGTGGGTTGTTCCCGTACGACAAGGGCGACGGCAGCATCATCAAGCCGCAGACCGTCATCGAGACGCTCTACGAGGTTACCCATGGCGATGCCTTCATCACCTCCGATGTCGGCCAGCACCAGATGTTCGCCTCGCAGTACTACAAGTTCAACAAGCCCAATCGCTGGATCAACTCCGGCGGTCTCGGCACCATGGGCTTCGGCTTCCCGGCGGCGATGGGCATCAAGCTCAACTTCCCGGACGACGATGTCGCCTGCGTGACCGGCGAGGGCAGTATCCAGATGAATATCCAGGAACTGTCTACCTGCCTGCAGTACGACCTGCCGGTGAAGATCGTCAACCTGAACAATGGTGCCCTGGGCATGGTCCGCCAGTGGCAGGACATGCAGTACAACAGCCGTTATTCGCATTCCTACATGGAATCCCTGCCGGACTTCGTCAAGCTTGCCGAAGCCTACGGGCATGTCGGCATGCGCATCACCGACCTGAAGGATCTGAAGCCGAAGATGGAGGAGGCGTTCGCCATGAAGAATCGCCTGGTCTTCCTCGACATCCAGGTGGACGCCAGCGAACACGTCTATCCGATGCAGATCCGTGACGGCGCGATGCGCGACATGTGGCTGAGCAAGACGGAGCGTACCTGA
Protein Properties
Protein Residues: 574
Protein Molecular Weight: 63 kDa
Protein Theoretical pI: 6.77
Hydropathicity (GRAVY score): -0.12
Charge at pH 7 (predicted): -1.99
Protein Sequence: 
>PA4696
MELLSGAEMVVRSLRDEGVKYIYGYPGGALLHIYDALFKEHDVTHILVRHEQAATHMADGYARATGKPGVVLVTSGPGATNAITGIATAYMDSIPMVILSGQVPSNMVGTDAFQETDMVGISRPIVKHSFIIKHPSEIPEVIKKAFYLAQSGRPGPVVVDIPKDMGDPTQKFEYSYPKKVKLRSYSPAVRGHSGQIRKAAEMLLAAKRPVVYSGGGVIMGNAAAPLTELAQMLNLPVTNTLMGLGGYPGADRQFLGMLGMHGSFTANLAMHHSDVILAVGARFDDRVINGAAKFCPNAKIIHIDIDPASISKTIKADIPIVGPVDSVLTEMVAIVREIGETPNQDAQAAWWKQIDEWRGNRGLFPYDKGDGSIIKPQTVIETLYEVTHGDAFITSDVGQHQMFASQYYKFNKPNRWINSGGLGTMGFGFPAAMGIKLNFPDDDVACVTGEGSIQMNIQELSTCLQYDLPVKIVNLNNGALGMVRQWQDMQYNSRYSHSYMESLPDFVKLAEAYGHVGMRITDLKDLKPKMEEAFAMKNRLVFLDIQVDASEHVYPMQIRDGAMRDMWLSKTERT
References
External Links:
Resource Link
Genome ID: PA4696
Entrez Gene ID: 881496
NCBI Protein ID: 15599890
General Reference: PaperBLAST - Find papers about PA4696 and its homologs