Orotidine 5'-phosphate decarboxylase (PA2876)

Identification
Name: Orotidine 5'-phosphate decarboxylase
Synonyms:
  • OMP decarboxylase
  • OMPDCase
  • OMPdecase
Gene Name: pyrF
Enzyme Class:
Biological Properties
General Function: Involved in catalytic activity
Specific Function: Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)
Cellular Location: Not Available
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb ↔ Thumb+Thumb
Hydrogen ion + Orotidylic acid ↔ Carbon dioxide + Uridine 5'-monophosphate
ReactionCard
Thumb ↔ Thumb+Thumb
Orotidylic acid ↔ Uridine 5'-monophosphate + Carbon dioxide
ReactionCard
SMPDB Reactions:
Thumb+Thumb → Thumb+Thumb
Orotidylic acid + Hydrogen ion → Carbon dioxide + Uridine 5'-monophosphate
ReactionCard
PseudoCyc/BioCyc Reactions:
Thumb+Thumb ↔ Thumb+Thumb
Hydrogen ion + Orotidylic acid ↔ Carbon dioxide + Uridine 5'-monophosphate
ReactionCard
Complex Reactions:
Thumb → Thumb+Thumb
Orotidylic acid → Uridine 5'-monophosphate + Carbon dioxide
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB000568Carbon dioxideMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB000090Orotidylic acidMetaboCard
PAMDB000118Uridine 5'-monophosphateMetaboCard
GO Classification:
Function
carbon-carbon lyase activity
carboxy-lyase activity
catalytic activity
lyase activity
orotidine-5'-phosphate decarboxylase activity
Process
'de novo' pyrimidine base biosynthetic process
'de novo' UMP biosynthetic process
cellular aromatic compound metabolic process
cellular metabolic process
cellular nitrogen compound metabolic process
metabolic process
nitrogen compound metabolic process
nucleobase metabolic process
nucleobase, nucleoside and nucleotide metabolic process
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
nucleoside phosphate metabolic process
nucleotide metabolic process
pyrimidine base biosynthetic process
pyrimidine base metabolic process
pyrimidine nucleoside monophosphate biosynthetic process
pyrimidine nucleotide biosynthetic process
pyrimidine nucleotide metabolic process
pyrimidine ribonucleoside monophosphate biosynthetic process
UMP biosynthetic process
Gene Properties
Locus tag: PA2876
Strand: -
Entrez Gene ID: 882585
Accession: NP_251566.1
GI: 15598072
Sequence start: 3229484
Sequence End: 3230182
Sequence Length: 698
Gene Sequence: 
>PA2876
ATGTCCGCCTGCCAGTCCCCCATCATCGTCGCCCTGGATTTCCCCACCCGTGAGGCCGCCCTGGCGCTGGCCGATCAGCTGGACCCGAAACTGTGCCGGGTGAAGGTCGGCAAGGAACTCTTCACCAGTTGTGCCGCGGGTATAGTCGAGACCTTGCGTGGCAAGGGCTTCGAGGTGTTCCTCGACCTGAAATTCCACGACATCCCGAACACCACGGCGATGGCGGTGAAGGCCGCCGCCGAGATGGGCGTGTGGATGGTCAACGTGCACTGCTCCGGCGGCCTGCGCATGATGGCCGCCTGCCGCGAGACGCTGGAGGCCTTCAGCGGGCCCAGGCCGTTGCTCATCGGCGTGACCGTGCTGACCAGCATGGAGCGCGAGGACCTGGCGGGCATCGGCCTCGACATCGAGCCCCAGGAGCAGGTGTTGCGCCTCGCCGCCCTGGCGCAGAAGGCCGGCATGGACGGCCTGGTCTGCTCGGCCCAGGAAGCGCCGGCGCTGAAGGCCGCCCATCCGGGCCTGCAACTGGTCACGCCGGGCATCCGCCCGGCCGGCAGCGCCCAGGACGACCAGCGGCGCATCCTCACCCCGCGCCAGGCCCTGGACGCCGGCTCCGATTACCTGGTGATCGGCCGGCCGATCAGCCAGGCCGCCGACCCGGCCAAGGCGCTGGCGGCGATCGTCGCCGAACTGGGCTGA
Protein Properties
Protein Residues: 232
Protein Molecular Weight: 24.4 kDa
Protein Theoretical pI: 5.33
Hydropathicity (GRAVY score): 0.234
Charge at pH 7 (predicted): -3.46
Protein Sequence: 
>PA2876
MSACQSPIIVALDFPTREAALALADQLDPKLCRVKVGKELFTSCAAGIVETLRGKGFEVFLDLKFHDIPNTTAMAVKAAAEMGVWMVNVHCSGGLRMMAACRETLEAFSGPRPLLIGVTVLTSMEREDLAGIGLDIEPQEQVLRLAALAQKAGMDGLVCSAQEAPALKAAHPGLQLVTPGIRPAGSAQDDQRRILTPRQALDAGSDYLVIGRPISQAADPAKALAAIVAELG
References
External Links:
Resource Link
Genome ID: PA2876
Entrez Gene ID: 882585
NCBI Protein ID: 15598072
General Reference: PaperBLAST - Find papers about PA2876 and its homologs