Coenzyme A biosynthesis bifunctional protein coaBC (PA5320)

Identification
Name: Coenzyme A biosynthesis bifunctional protein coaBC
Synonyms:
  • DNA/pantothenate metabolism flavoprotein
  • Phosphopantothenoylcysteine decarboxylase
  • PPCDC
  • CoaC
  • Phosphopantothenate--cysteine ligase
  • CoaB
  • PPC synthetase
  • PPCS
  • Phosphopantothenoylcysteine synthase
Gene Name: coaBC
Enzyme Class:
Biological Properties
General Function: Involved in phosphopantothenate--cysteine ligase activity
Specific Function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Cellular Location: Not Available
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb+Thumb → Thumb+Thumb+Thumb+Thumb
D-4'-Phosphopantothenate + Cytidine triphosphate + L-Cysteine → 4-Phosphopantothenoylcysteine + Cytidine monophosphate + Hydrogen ion + Pyrophosphate
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Thumb+Thumb ↔ Thumb+Thumb+Thumb
4-Phosphopantothenoylcysteine + Hydrogen ion ↔ Carbon dioxide + Pantetheine 4'-phosphate + pantotheine 4'-phosphate
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Thumb ↔ Thumb+Thumb
4-Phosphopantothenoylcysteine ↔ Pantetheine 4'-phosphate + Carbon dioxide
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Thumb+Thumb+Thumb ↔ Thumb+Thumb+Thumb
Adenosine triphosphate + D-4'-Phosphopantothenate + L-Cysteine ↔ Adenosine monophosphate + Pyrophosphate + 4-Phosphopantothenoylcysteine
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Thumb+Thumb+Thumb ↔ Thumb+Thumb+Thumb
Cytidine triphosphate + D-4'-Phosphopantothenate + L-Cysteine ↔ Cytidine monophosphate + Pyrophosphate + 4-Phosphopantothenoylcysteine
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Thumb+Thumb+Thumb → Thumb+Thumb+Thumb+Thumb
D-4'-Phosphopantothenate + L-Cysteine + Cytidine triphosphate → Hydrogen ion + Pyrophosphate + Cytidine monophosphate + 4-Phosphopantothenoylcysteine
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SMPDB Reactions:
Thumb → Pantetheine 4'-phosphate+Thumb+Thumb
4-Phosphopantothenoylcysteine → Pantetheine 4'-phosphate + Carbon dioxide + pantotheine 4'-phosphate
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D-4'-Phosphopantothenate+Thumb+Thumb+Thumb → Cytidine monophosphate+Pyrophosphate+Thumb+Thumb+Thumb
D-4'-Phosphopantothenate + Cytidine triphosphate + L-Cysteine + D-4'-Phosphopantothenate → Cytidine monophosphate + Pyrophosphate + Hydrogen ion + 4-Phosphopantothenoylcysteine + Cytidine monophosphate
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Thumb+Thumb → Thumb+4'-phosphopantetheine+Thumb
4-Phosphopantothenoylcysteine + Hydrogen ion → Carbon dioxide + 4'-phosphopantetheine + 4'-phosphopantetheine
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PseudoCyc/BioCyc Reactions:
Thumb+Thumb+Thumb → Thumb+Thumb+Thumb+Thumb
D-4'-Phosphopantothenate + Cytidine triphosphate + L-Cysteine → 4-Phosphopantothenoylcysteine + Cytidine monophosphate + Hydrogen ion + Pyrophosphate
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Thumb+Thumb ↔ Thumb+Thumb+Thumb
4-Phosphopantothenoylcysteine + Hydrogen ion ↔ Carbon dioxide + Pantetheine 4'-phosphate + pantotheine 4'-phosphate
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Thumb+Thumb+Thumb → Thumb+Thumb+Thumb+Thumb
D-4'-Phosphopantothenate + L-Cysteine + Cytidine triphosphate → Hydrogen ion + Pyrophosphate + Cytidine monophosphate + 4-Phosphopantothenoylcysteine
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Complex Reactions:
Thumb → Thumb+Thumb
4-Phosphopantothenoylcysteine → pantotheine 4'-phosphate + Carbon dioxide
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Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB0063304'-phosphopantetheineMetaboCard
PAMDB0002594-PhosphopantothenoylcysteineMetaboCard
PAMDB000014Adenosine monophosphateMetaboCard
PAMDB000148Adenosine triphosphateMetaboCard
PAMDB000568Carbon dioxideMetaboCard
PAMDB000035Cytidine monophosphateMetaboCard
PAMDB000030Cytidine triphosphateMetaboCard
PAMDB000227D-4'-PhosphopantothenateMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB000152L-CysteineMetaboCard
PAMDB000379Pantetheine 4'-phosphateMetaboCard
PAMDB003606pantotheine 4'-phosphateMetaboCard
PAMDB000633PyrophosphateMetaboCard
GO Classification:
Function
acid-amino acid ligase activity
binding
carbon-carbon lyase activity
carboxy-lyase activity
catalytic activity
FMN binding
ligase activity
ligase activity, forming carbon-nitrogen bonds
lyase activity
nucleotide binding
phosphopantothenate--cysteine ligase activity
phosphopantothenoylcysteine decarboxylase activity
Process
cellular metabolic process
coenzyme A biosynthetic process
coenzyme biosynthetic process
coenzyme catabolic process
coenzyme metabolic process
cofactor metabolic process
metabolic process
pantothenate catabolic process
Gene Properties
Locus tag: PA5320
Strand: +
Entrez Gene ID: 877887
Accession: NP_254007.1
GI: 15600513
Sequence start: 5989460
Sequence End: 5990668
Sequence Length: 1208
Gene Sequence: 
>PA5320
ATGCAGCGGCTCTATCGGAAACGCATCGTCCTCGGCGTGGGCGGCGGCATTGCCGCCTACAAGAGCGCCGAACTGGTCCGCCGCCTGCGCGACCAGGGCGCTGAAGTCCGAGTGGTGATGACCCAGGGCGGCCGCGAGTTCATCACGCCCCTGACCCTCCAGGCGTTGTCCGGCCATCCGGTGCATACCGATCTGCTGGACCCGGCGGCGGAAGCCGCGATGGGCCACATCGAACTGGCCCGCTGGGCCGATCTGGTGCTGATCGCACCGGCTACCGCCGACCTCATGGCGCGCCTGGTCCAGGGCGTGGCCAACGACCTGCTGACCACCCTGGTGCTGGCCACCGACGCGCAAATCGCCCTGGCACCGGCGATGAACCAGGCCATGTGGCGCGACACCGCGACCCAGGCCAACGCCGAGCTGCTGCGCCAGCGCGGCTTCCACCTGTTCGGTCCGGCAGCGGGCAGCCAGGCCTGCGGCGACGTCGGCCTCGGACGCATGCTCGAAGCCGAGGAACTGGCGCAGCGCGCCGCCGACTGCTTCCAGCGCCAGGCGCTGACCGGCGTGCATGTGCTGATCACCGCCGGCCCGACCCAGGAAAACATCGACCCGGTGCGCTACATCACCAACCACAGTTCCGGAAAGATGGGCTTCGCCCTCGCCGAGGCGGCGGTGGAAGCCGGCGCACGGGTGACCCTGGTCACCGGCCCGGTGCACCTGCCCACGCCCGACCGGGTGCAGCGCGTCGACGTGGTCAGCGCCCGCGACATGCTGGCCGCCTGCGAGGCGGCGATGCCCTGCGACCTGCTGATCGCCTCCGCGGCGGTCGCCGACTACCGCCCGGAAGTGGTCGCCGCGCACAAACTGAAGAAAGACCCTACCAGCGGCGAGGGCTTGCTCTTGCAGCTGGTGCGCAATCCCGACATTCTCGCCACCCTCGCACAGCGCGAGGATCGTCCCTTCAGCGTGGGCTTCGCCGCAGAAACCGAAAACCTGCTGGACTATGCTGCACGCAAGCTCAAGGACAAGAACCTCGACCTGATCGTCGCCAACGACGTGGCCAACCCCTCGATCGGCTTCAACAGCGACGAGAACGCGATCACGGTGATCGACCGCGACCTGCATCCGAGCACCTTCGCCCAGACCAGCAAGGGCAAGATCGCTCGCCAGCTGGTCGCCTTCATCGCCGACCGCCTCAACCAGCAATGA
Protein Properties
Protein Residues: 402
Protein Molecular Weight: 43.1 kDa
Protein Theoretical pI: 6.25
Hydropathicity (GRAVY score): 0.022
Charge at pH 7 (predicted): -3.94
Protein Sequence: 
>PA5320
MQRLYRKRIVLGVGGGIAAYKSAELVRRLRDQGAEVRVVMTQGGREFITPLTLQALSGHPVHTDLLDPAAEAAMGHIELARWADLVLIAPATADLMARLVQGVANDLLTTLVLATDAQIALAPAMNQAMWRDTATQANAELLRQRGFHLFGPAAGSQACGDVGLGRMLEAEELAQRAADCFQRQALTGVHVLITAGPTQENIDPVRYITNHSSGKMGFALAEAAVEAGARVTLVTGPVHLPTPDRVQRVDVVSARDMLAACEAAMPCDLLIASAAVADYRPEVVAAHKLKKDPTSGEGLLLQLVRNPDILATLAQREDRPFSVGFAAETENLLDYAARKLKDKNLDLIVANDVANPSIGFNSDENAITVIDRDLHPSTFAQTSKGKIARQLVAFIADRLNQQ
References
External Links:
Resource Link
Genome ID: PA5320
Entrez Gene ID: 877887
NCBI Protein ID: 15600513
General Reference: PaperBLAST - Find papers about PA5320 and its homologs