Identification |
Name: |
Coenzyme A biosynthesis bifunctional protein coaBC |
Synonyms: |
- DNA/pantothenate metabolism flavoprotein
- Phosphopantothenoylcysteine decarboxylase
- PPCDC
- CoaC
- Phosphopantothenate--cysteine ligase
- CoaB
- PPC synthetase
- PPCS
- Phosphopantothenoylcysteine synthase
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Gene Name: |
coaBC |
Enzyme Class: |
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Biological Properties |
General Function: |
Involved in phosphopantothenate--cysteine ligase activity |
Specific Function: |
Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine |
Cellular Location: |
Not Available |
KEGG Pathways: |
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KEGG Reactions: |
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SMPDB Reactions: |
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![Thumb](/molecules/PAMDB000259thumb.png) | → | Pantetheine 4'-phosphate | + | ![Thumb](/molecules/PAMDB000568thumb.png) | + | ![Thumb](/molecules/PAMDB003606thumb.png) |
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D-4'-Phosphopantothenate | + | ![Thumb](/molecules/PAMDB000030thumb.png) | + | ![Thumb](/molecules/PAMDB000152thumb.png) | + | ![Thumb](/molecules/PAMDB000227thumb.png) | → | Cytidine monophosphate | + | Pyrophosphate | + | ![Thumb](/molecules/PAMDB001633thumb.png) | + | ![Thumb](/molecules/PAMDB000259thumb.png) | + | ![Thumb](/molecules/PAMDB000035thumb.png) |
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![Thumb](/molecules/PAMDB000259thumb.png) | + | ![Thumb](/molecules/PAMDB001633thumb.png) | → | ![Thumb](/molecules/PAMDB000568thumb.png) | + | 4'-phosphopantetheine | + | ![Thumb](/molecules/PAMDB006330thumb.png) |
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PseudoCyc/BioCyc Reactions: |
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Complex Reactions: |
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Transports: |
Not Available |
Metabolites: |
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GO Classification: |
Function |
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acid-amino acid ligase activity | binding | carbon-carbon lyase activity | carboxy-lyase activity | catalytic activity | FMN binding | ligase activity | ligase activity, forming carbon-nitrogen bonds | lyase activity | nucleotide binding | phosphopantothenate--cysteine ligase activity | phosphopantothenoylcysteine decarboxylase activity | Process |
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cellular metabolic process | coenzyme A biosynthetic process | coenzyme biosynthetic process | coenzyme catabolic process | coenzyme metabolic process | cofactor metabolic process | metabolic process | pantothenate catabolic process |
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Gene Properties |
Locus tag: |
PA5320 |
Strand: |
+ |
Entrez Gene ID: |
877887 |
Accession: |
NP_254007.1 |
GI: |
15600513 |
Sequence start: |
5989460 |
Sequence End: |
5990668 |
Sequence Length: |
1208 |
Gene Sequence: |
>PA5320
ATGCAGCGGCTCTATCGGAAACGCATCGTCCTCGGCGTGGGCGGCGGCATTGCCGCCTACAAGAGCGCCGAACTGGTCCGCCGCCTGCGCGACCAGGGCGCTGAAGTCCGAGTGGTGATGACCCAGGGCGGCCGCGAGTTCATCACGCCCCTGACCCTCCAGGCGTTGTCCGGCCATCCGGTGCATACCGATCTGCTGGACCCGGCGGCGGAAGCCGCGATGGGCCACATCGAACTGGCCCGCTGGGCCGATCTGGTGCTGATCGCACCGGCTACCGCCGACCTCATGGCGCGCCTGGTCCAGGGCGTGGCCAACGACCTGCTGACCACCCTGGTGCTGGCCACCGACGCGCAAATCGCCCTGGCACCGGCGATGAACCAGGCCATGTGGCGCGACACCGCGACCCAGGCCAACGCCGAGCTGCTGCGCCAGCGCGGCTTCCACCTGTTCGGTCCGGCAGCGGGCAGCCAGGCCTGCGGCGACGTCGGCCTCGGACGCATGCTCGAAGCCGAGGAACTGGCGCAGCGCGCCGCCGACTGCTTCCAGCGCCAGGCGCTGACCGGCGTGCATGTGCTGATCACCGCCGGCCCGACCCAGGAAAACATCGACCCGGTGCGCTACATCACCAACCACAGTTCCGGAAAGATGGGCTTCGCCCTCGCCGAGGCGGCGGTGGAAGCCGGCGCACGGGTGACCCTGGTCACCGGCCCGGTGCACCTGCCCACGCCCGACCGGGTGCAGCGCGTCGACGTGGTCAGCGCCCGCGACATGCTGGCCGCCTGCGAGGCGGCGATGCCCTGCGACCTGCTGATCGCCTCCGCGGCGGTCGCCGACTACCGCCCGGAAGTGGTCGCCGCGCACAAACTGAAGAAAGACCCTACCAGCGGCGAGGGCTTGCTCTTGCAGCTGGTGCGCAATCCCGACATTCTCGCCACCCTCGCACAGCGCGAGGATCGTCCCTTCAGCGTGGGCTTCGCCGCAGAAACCGAAAACCTGCTGGACTATGCTGCACGCAAGCTCAAGGACAAGAACCTCGACCTGATCGTCGCCAACGACGTGGCCAACCCCTCGATCGGCTTCAACAGCGACGAGAACGCGATCACGGTGATCGACCGCGACCTGCATCCGAGCACCTTCGCCCAGACCAGCAAGGGCAAGATCGCTCGCCAGCTGGTCGCCTTCATCGCCGACCGCCTCAACCAGCAATGA |
Protein Properties |
Protein Residues: |
402 |
Protein Molecular Weight: |
43.1 kDa |
Protein Theoretical pI: |
6.25 |
Hydropathicity (GRAVY score): |
0.022 |
Charge at pH 7 (predicted): |
-3.94 |
Protein Sequence: |
>PA5320
MQRLYRKRIVLGVGGGIAAYKSAELVRRLRDQGAEVRVVMTQGGREFITPLTLQALSGHPVHTDLLDPAAEAAMGHIELARWADLVLIAPATADLMARLVQGVANDLLTTLVLATDAQIALAPAMNQAMWRDTATQANAELLRQRGFHLFGPAAGSQACGDVGLGRMLEAEELAQRAADCFQRQALTGVHVLITAGPTQENIDPVRYITNHSSGKMGFALAEAAVEAGARVTLVTGPVHLPTPDRVQRVDVVSARDMLAACEAAMPCDLLIASAAVADYRPEVVAAHKLKKDPTSGEGLLLQLVRNPDILATLAQREDRPFSVGFAAETENLLDYAARKLKDKNLDLIVANDVANPSIGFNSDENAITVIDRDLHPSTFAQTSKGKIARQLVAFIADRLNQQ |
References |
External Links: |
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General Reference: |
PaperBLAST - Find papers about PA5320 and its homologs
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