Uroporphyrinogen decarboxylase (PA5034)

Identification
Name: Uroporphyrinogen decarboxylase
Synonyms:
  • UPD
  • URO-D
Gene Name: hemE
Enzyme Class:
Biological Properties
General Function: Involved in uroporphyrinogen decarboxylase activity
Specific Function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
Cellular Location: Cytoplasm (Probable)
KEGG Pathways:
KEGG Reactions:
4 Thumb+Thumb ↔ 4 Thumb+Thumb
4 Hydrogen ion + Uroporphyrinogen III ↔ 4 Carbon dioxide + Coproporphyrin III
ReactionCard
Thumb ↔ Thumb+4 Thumb
Uroporphyrinogen III ↔ Coproporphyrin III + 4 Carbon dioxide
ReactionCard
Thumb ↔ Thumb+4 Thumb
Uroporphyrinogen I ↔ Coproporphyrinogen I + 4 Carbon dioxide
ReactionCard
SMPDB Reactions:
Thumb+4 Thumb → 4 Thumb+Thumb
Uroporphyrinogen III + 4 Hydrogen ion → 4 Carbon dioxide + Coproporphyrinogen III
ReactionCard
Thumb+4 Thumb → 4 Thumb+Thumb
Uroporphyrinogen I + 4 Hydrogen ion → 4 Carbon dioxide + Coproporphyrinogen I
ReactionCard
PseudoCyc/BioCyc Reactions:
Thumb+Thumb → Thumb+Thumb
Hydrogen ion + Uroporphyrinogen III → Carbon dioxide + Coproporphyrinogen III
ReactionCard
Complex Reactions:
Thumb → Thumb+4 Thumb
Uroporphyrinogen III → Coproporphyrinogen III + 4 Carbon dioxide
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB000568Carbon dioxideMetaboCard
PAMDB000151Coproporphyrin IIIMetaboCard
PAMDB000442Coproporphyrinogen IMetaboCard
PAMDB000314Coproporphyrinogen IIIMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB000447Uroporphyrinogen IMetaboCard
PAMDB000248Uroporphyrinogen IIIMetaboCard
GO Classification:
Function
carbon-carbon lyase activity
carboxy-lyase activity
catalytic activity
lyase activity
uroporphyrinogen decarboxylase activity
Process
metabolic process
nitrogen compound metabolic process
porphyrin biosynthetic process
porphyrin metabolic process
tetrapyrrole metabolic process
Gene Properties
Locus tag: PA5034
Strand: -
Entrez Gene ID: 881202
Accession: NP_253721.1
GI: 15600227
Sequence start: 5664990
Sequence End: 5666057
Sequence Length: 1067
Gene Sequence: 
>PA5034
ATGACTGCCCTGAAGAACGACCGCTTCCTCCGCGCCCTGCTCAAGCAGCCCGTCGATGTCACCCCCGTCTGGATGATGCGCCAGGCCGGTCGTTACCTGCCGGAATACCGTGCCACCCGTGCCAAGGCCGGCGATTTCATGAGCCTGTGCATGAACCCGGAGCTGGCCTGCGAAGTGACCCTGCAGCCGCTGGACCGTTACCCGCAGCTGGACGCCGCGATCCTCTTCTCCGATATCCTGACCATTCCCGATGCCATGGGCCAGGGCCTGTACTTCGAGACCGGCGAAGGCCCGCGCTTCCGCAAGGTGGTCTCGTCGCTGGCCGACATCGAGGCGCTGCCGGTTCCCGATCCGGAACAGGACCTGGGCTATGTGATGGACGCCGTGCGCACCATCCGCCGCGAGCTGAACGGCCGCGTACCGCTGATCGGCTTCTCCGGCAGCCCCTGGACCCTCGCCACCTACATGGTCGAGGGCGGCTCGAGCAAGGACTTCCGCAAGTCCAAGGCGATGCTCTACGACAACCCCAAGGCCATGCACGCTCTGCTGGACAAGCTGGCGCAATCGGTGACCAGCTACCTCAACGGGCAGATCCACGCCGGCGCCCAGGCGGTGCAGATCTTCGACTCATGGGGCGGCAGCCTGTCGGCGGCGGCCTACCAGGAGTTCTCCCTGGCCTACATGCGCAAGATCGTCGATGGATTGATCCGCGAGCACGACGGACGCCGGGTGCCGGTGATCCTCTTCACCAAGGGAGGCGGCCTGTGGCTGGAGTCGATGGCCGAGGTCGGCGCCGAGGCGCTGGGCCTGGACTGGACCTGCGACATCGGCAGCGCCCGGGCCCGTGTCGGTGAGCGCGTAGCCCTGCAAGGCAACATGGATCCTTCGGTGCTCTACGCCAATCCGGCGGCGATCCGCGCCGAAGTCGCGCGGATCCTGGCGGCCTACGGCAAGGGTACGGGGCATGTGTTCAATCTCGGCCACGGCATCACCCCGGAAGTCGACCCGGCCCATGCCGGCGCCTTCTTCGAGGCGGTGCACGAGCTGTCGGCGCAGTACCACGGCTGA
Protein Properties
Protein Residues: 355
Protein Molecular Weight: 38.8 kDa
Protein Theoretical pI: 6.32
Hydropathicity (GRAVY score): -0.069
Charge at pH 7 (predicted): -3.17
Protein Sequence: 
>PA5034
MTALKNDRFLRALLKQPVDVTPVWMMRQAGRYLPEYRATRAKAGDFMSLCMNPELACEVTLQPLDRYPQLDAAILFSDILTIPDAMGQGLYFETGEGPRFRKVVSSLADIEALPVPDPEQDLGYVMDAVRTIRRELNGRVPLIGFSGSPWTLATYMVEGGSSKDFRKSKAMLYDNPKAMHALLDKLAQSVTSYLNGQIHAGAQAVQIFDSWGGSLSAAAYQEFSLAYMRKIVDGLIREHDGRRVPVILFTKGGGLWLESMAEVGAEALGLDWTCDIGSARARVGERVALQGNMDPSVLYANPAAIRAEVARILAAYGKGTGHVFNLGHGITPEVDPAHAGAFFEAVHELSAQYHG
References
External Links:
Resource Link
Genome ID: PA5034
Entrez Gene ID: 881202
NCBI Protein ID: 15600227
General Reference: PaperBLAST - Find papers about PA5034 and its homologs