Biotin carboxyl carrier protein of acetyl-CoA carboxylase (PA4847)

Identification
Name: Biotin carboxyl carrier protein of acetyl-CoA carboxylase
Synonyms:
  • BCCP
Gene Name: accB
Enzyme Class: Not Available
Biological Properties
General Function: Involved in acetyl-CoA carboxylase activity
Specific Function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA
Cellular Location: Not Available
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb+Thumb ↔ Thumb+Thumb+Thumb+Thumb
Acetyl-CoA + Adenosine triphosphate + Hydrogen carbonate ↔ ADP + Hydrogen ion + Malonyl-CoA + Phosphate
ReactionCard
Thumb+Thumb+Thumb ↔ Thumb+Thumb+Thumb
Adenosine triphosphate + Acetyl-CoA + Hydrogen carbonate ↔ ADP + Phosphate + Malonyl-CoA
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Thumb+Carboxybiotin-carboxyl-carrier protein ↔ Thumb+Holo-[carboxylase]
Acetyl-CoA + Carboxybiotin-carboxyl-carrier protein ↔ Malonyl-CoA + Holo-[carboxylase]
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SMPDB Reactions:
Thumb+Thumb+Thumb → Adenosine diphosphate+Thumb+Thumb+Malonyl-CoA+Thumb+Thumb
Acetyl-CoA + Hydrogen carbonate + Adenosine triphosphate → Adenosine diphosphate + Phosphate + Hydrogen ion + Malonyl-CoA + ADP + Malonyl-CoA
ReactionCard
a biotinylated [BCCP dimer]+Thumb+Thumb → carboxylated-biotinylated [BCCP dimer]+Thumb+Thumb+Thumb
a biotinylated [BCCP dimer] + Adenosine triphosphate + Hydrogen carbonate → carboxylated-biotinylated [BCCP dimer] + Hydrogen ion + ADP + Phosphate
ReactionCard
PseudoCyc/BioCyc Reactions:
Thumb+Thumb+Thumb ↔ Thumb+Thumb+Thumb+Thumb
Acetyl-CoA + Adenosine triphosphate + Hydrogen carbonate ↔ ADP + Hydrogen ion + Malonyl-CoA + Phosphate
ReactionCard
Complex Reactions: Not Available
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB000298Acetyl-CoAMetaboCard
PAMDB000148Adenosine triphosphateMetaboCard
PAMDB000345ADPMetaboCard
PAMDB000153Hydrogen carbonateMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB000284Malonyl-CoAMetaboCard
PAMDB000383PhosphateMetaboCard
GO Classification:
Component
acetyl-CoA carboxylase complex
macromolecular complex
protein complex
Function
acetyl-CoA carboxylase activity
binding
biotin binding
catalytic activity
CoA carboxylase activity
ligase activity
ligase activity, forming carbon-carbon bonds
vitamin binding
Process
carboxylic acid metabolic process
cellular metabolic process
fatty acid biosynthetic process
fatty acid metabolic process
metabolic process
monocarboxylic acid metabolic process
organic acid metabolic process
oxoacid metabolic process
Gene Properties
Locus tag: PA4847
Strand: +
Entrez Gene ID: 879557
Accession: NP_253534.1
GI: 15600040
Sequence start: 5442304
Sequence End: 5442774
Sequence Length: 470
Gene Sequence: 
>PA4847
ATGGACATTCGTAAAGTCAAGAAACTGATCGAGCTGCTGGAAGAGTCCGGTATCGACGAGCTGGAAATCCGCGAAGGCGAAGAGTCGGTACGCATCAGCCGCCACAGCAAGACCGCCGCCCAGCCGGTGTACGCACAGGCTCCGGCCTTCGCCGCTCCGGTCGCCGCGCCGGCGCCGGCAGCCGCCGCTCCGGCCGCCGCTGCCGCGGAAAGCGCCCCGGCCGCTCCGAAGCTGAACGGCAACGTGGTTCGCTCGCCGATGGTCGGCACCTTCTACCGCGCCGCCTCGCCGACCTCGGCCAACTTCGTCGAAGTCGGCCAGAGCGTGAAGAAAGGCGACATCCTGTGCATCGTCGAAGCCATGAAGATGATGAACCACATCGAAGCCGAAGTTAGCGGCACCATCGAGTCGATCCTGGTGGAGAACGGCCAGCCGGTTGAGTTCGACCAGCCGCTGTTCACCATCGTCTAA
Protein Properties
Protein Residues: 156
Protein Molecular Weight: 16.5 kDa
Protein Theoretical pI: 4.67
Hydropathicity (GRAVY score): 0.068
Charge at pH 7 (predicted): -5.55
Protein Sequence: 
>PA4847
MDIRKVKKLIELLEESGIDELEIREGEESVRISRHSKTAAQPVYAQAPAFAAPVAAPAPAAAAPAAAAAESAPAAPKLNGNVVRSPMVGTFYRAASPTSANFVEVGQSVKKGDILCIVEAMKMMNHIEAEVSGTIESILVENGQPVEFDQPLFTIV
References
External Links:
Resource Link
Genome ID: PA4847
Entrez Gene ID: 879557
NCBI Protein ID: 15600040
General Reference: PaperBLAST - Find papers about PA4847 and its homologs