P. aeruginosa Metabolome Database Protein PA5425

Identification

Name:

Phosphoribosylaminoimidazole carboxylase ATPase subunit

Synonyms:

AIR carboxylase
AIRC

Gene Name:

purK

Enzyme Class:

Biological Properties

General Function:

Involved in phosphoribosylaminoimidazole carboxylase activity

Specific Function:

Possesses an ATPase activity that is dependent on the presence of AIR (aminoimidazole ribonucleotide). The association of purK and purE produces an enzyme complex capable of converting AIR to CAIR efficiently under physiological condition

Cellular Location:

Not Available

KEGG Pathways:

Metabolic pathways pae01100
Purine metabolism pae00230

KEGG Reactions:

↔

5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole

Adenosine triphosphate + 5-Aminoimidazole ribonucleotide + Hydrogen carbonate ↔ ADP + Phosphate + 5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole + 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole
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↔

5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate ↔ 5-Aminoimidazole ribonucleotide + Carbon dioxide
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SMPDB Reactions:

→

N5-Carboxyaminoimidazole ribonucleotide

Adenosine diphosphate

5-Aminoimidazole ribonucleotide + Hydrogen carbonate + Adenosine triphosphate → N5-Carboxyaminoimidazole ribonucleotide + Adenosine diphosphate + Phosphate + 2 Hydrogen ion + N5-Carboxyaminoimidazole ribonucleotide + ADP
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→

5-Aminoimidazole ribonucleotide + Hydrogen carbonate + Adenosine triphosphate → 5-Phosphoribosyl-5-carboxyaminoimidazole + ADP + Phosphate + Hydrogen ion
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PseudoCyc/BioCyc Reactions:

→

5-Aminoimidazole ribonucleotide + Adenosine triphosphate + Hydrogen carbonate → 5-Phosphoribosyl-5-carboxyaminoimidazole + ADP + Hydrogen ion + Phosphate
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↔

5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole

→

Adenosine triphosphate + 5-Aminoimidazole ribonucleotide + Carbonic acid → ADP + Inorganic phosphate + 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole
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↔

5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate ↔ 5-Aminoimidazole ribonucleotide + Carbon dioxide
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→

N5-Carboxyaminoimidazole ribonucleotide

Adenosine diphosphate

5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + 2 H⁺ = 5-amino-1-(5-phospho-β-D-ribosyl)imidazole + CO₂
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Complex Reactions:

Transports:

Not Available

Metabolites:

PAMDB ID	Name	View
PAMDB000306	5-Aminoimidazole ribonucleotide	MetaboCard
PAMDB003410	5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole	MetaboCard
PAMDB001587	5-Phosphoribosyl-5-carboxyaminoimidazole	MetaboCard
PAMDB000148	Adenosine triphosphate	MetaboCard
PAMDB000345	ADP	MetaboCard
PAMDB000510	Carbonic acid	MetaboCard
PAMDB000153	Hydrogen carbonate	MetaboCard
PAMDB001633	Hydrogen ion	MetaboCard
PAMDB001776	Inorganic phosphate	MetaboCard
PAMDB000337	N5-Carboxyaminoimidazole ribonucleotide	MetaboCard
PAMDB000383	Phosphate	MetaboCard

GO Classification:

Function
adenyl nucleotide binding
adenyl ribonucleotide binding
ATP binding
binding
carbon-carbon lyase activity
carboxy-lyase activity
catalytic activity
lyase activity
nucleoside binding
phosphoribosylaminoimidazole carboxylase activity
purine nucleoside binding
Process
'de novo' IMP biosynthetic process
cellular nitrogen compound metabolic process
IMP biosynthetic process
metabolic process
nitrogen compound metabolic process
nucleobase, nucleoside and nucleotide metabolic process
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
nucleoside phosphate metabolic process
nucleotide metabolic process
purine nucleoside monophosphate biosynthetic process
purine nucleotide biosynthetic process
purine nucleotide metabolic process
purine ribonucleoside monophosphate biosynthetic process

Gene Properties

Locus tag:

PA5425

Strand:

Entrez Gene ID:

878440

Accession:

NP_254112.1

GI:

15600618

Sequence start:

6105159

Sequence End:

6106241

Sequence Length:

1082

Gene Sequence:

>PA5425
ATGAAAATCGGTGTCATCGGTGGCGGCCAGCTGGGCCGCATGCTGGCCCTGGCGGGAACCCCGCTGGGCATGAACTTCGCTTTCCTCGACCCGGCGCCGGACGCCTGCGCGGCCTCCCTGGGCGAGCACATCCGCGCCGACTACGGCGACCAGGAGCACCTGCGGCAACTGGCCGACGAGGTCGACCTGGTAACCTTCGAGTTCGAGAGCGTGCCGGCGGAAACCGTGGCCTTCCTCTCCCAGTTCGTGCCGGTCTACCCGAACGCCGAGTCGCTGCGCATCGCCCGCGACCGCTGGTTCGAGAAGTCGATGTTCAAGGACCTTGGCATTCCCACTCCGGACTTCGCCGACGTCCAGTCCCAGGCCGACCTCGATGCCGCCGCAGCCGCCATCGGCCTGCCGGCGGTGCTCAAGACCCGCACCCTGGGCTACGACGGCAAGGGCCAGAAGGTCCTGCGCCAGCCGGCCGACGTGCAGGGCGCGTTCGCCGAACTGGGCAGCGTGCCGTGCATCCTCGAGGGCTTCGTGCCGTTCACCGGGGAAGTCTCGCTGGTGGCGGTGCGCGCTCGCGATGGCGAGACGCGTTTCTACCCGCTGGTGCACAACACCCACGACAGCGGCATCCTCAAGCTCTCCGTGGCCAGCAGCGGGCATCCGTTGCAGGCGCTGGCCGAGGACTACGTCGGCCGCGTGCTGGCCCGGCTCGACTACGTCGGCGTGCTGGCCTTCGAGTTCTTCGAGGTGGACGGCGGCCTGAAGGCCAACGAGATCGCCCCGCGCGTGCACAACTCCGGGCACTGGACCATCGAAGGCGCCGAGTGCAGCCAGTTCGAGAACCACTTGCGCGCCGTCGCCGGCCTGCCGCTGGGCTCGACCGCCAAGGTCGGCGAGAGCGCGATGCTCAATTTCATCGGCGCGGTCCCCCCGGTGGCTCAGGTGGTCGCCGTCGCCGACTGCCACCTGCATCACTACGGCAAGGCCTTCAAGAACGGCCGCAAGGTCGGCCACGCCACCCTGCGTTGTGCCGACCGGGCGACGCTGCAGGCGCGCATCGCCGAGGTCGAGGCGCTGATCGAGGCGTGA

Protein Properties

Protein Residues:

360

Protein Molecular Weight:

38.5 kDa

Protein Theoretical pI:

5.38

Hydropathicity (GRAVY score):

0.082

Charge at pH 7 (predicted):

-10.26

Protein Sequence:

>PA5425
MKIGVIGGGQLGRMLALAGTPLGMNFAFLDPAPDACAASLGEHIRADYGDQEHLRQLADEVDLVTFEFESVPAETVAFLSQFVPVYPNAESLRIARDRWFEKSMFKDLGIPTPDFADVQSQADLDAAAAAIGLPAVLKTRTLGYDGKGQKVLRQPADVQGAFAELGSVPCILEGFVPFTGEVSLVAVRARDGETRFYPLVHNTHDSGILKLSVASSGHPLQALAEDYVGRVLARLDYVGVLAFEFFEVDGGLKANEIAPRVHNSGHWTIEGAECSQFENHLRAVAGLPLGSTAKVGESAMLNFIGAVPPVAQVVAVADCHLHHYGKAFKNGRKVGHATLRCADRATLQARIAEVEALIEA

References

External Links:

Resource	Link
Genome ID:	PA5425
Entrez Gene ID:	878440
NCBI Protein ID:	15600618

General Reference:

PaperBLAST - Find papers about PA5425 and its homologs

Phosphoribosylaminoimidazole carboxylase ATPase subunit (PA5425)