Reaction 21556

Reaction Details
Reaction: Thumb
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + 2 H+ = 5-amino-1-(5-phospho-β-D-ribosyl)imidazole + CO2
Enzymes:
External Links:
ResourceLink
PseudoCyc Reaction ID:AIRCARBOXY-RXN
References:
  • Firestine SM, Poon SW, Mueller EJ, Stubbe J, Davisson VJ (1994). "Reactions catalyzed by 5-aminoimidazole ribonucleotide carboxylases from Escherichia coli and Gallus gallus: a case for divergent catalytic mechanisms." Biochemistry 1994;33(39);11927-34. PMID: 7918411
  • Firestine SM, Misialek S, Toffaletti DL, Klem TJ, Perfect JR, Davisson VJ (1998). "Biochemical role of the Cryptococcus neoformans ADE2 protein in fungal de novo purine biosynthesis." Arch Biochem Biophys 351(1);123-34. PMID: 9500840
  • LUKENS LN, BUCHANAN JM (1959). "Biosynthesis of the purines. XXIV. The enzymatic synthesis of 5-amino-1-ribosyl-4-imidazolecarboxylic acid 5'-phosphate from 5-amino-1-ribosylimidazole 5'-phosphate and carbon dioxide." J Biol Chem 234(7);1799-805. PMID: 13672967