Phosphoribosylaminoimidazole carboxylase catalytic subunit (PA5426)

Identification
Name: Phosphoribosylaminoimidazole carboxylase catalytic subunit
Synonyms:
  • AIR carboxylase
  • AIRC
Gene Name: purE
Enzyme Class:
Biological Properties
General Function: Involved in 5-(carboxyamino)imidazole ribonucleotide mutase activity
Specific Function: This subunit can alone transform AIR to CAIR, but in association with purK, which possesses an ATPase activity, an enzyme complex is produced which is capable of converting AIR to CAIR efficiently under physiological condition
Cellular Location: Not Available
KEGG Pathways:
KEGG Reactions:
5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole+Thumb ↔ Thumb
5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole + 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole ↔ 5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate
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Thumb ↔ Thumb+Thumb
5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate ↔ 5-Aminoimidazole ribonucleotide + Carbon dioxide
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SMPDB Reactions:
N5-Carboxyaminoimidazole ribonucleotide+Thumb → Thumb
N5-Carboxyaminoimidazole ribonucleotide + N5-Carboxyaminoimidazole ribonucleotide → 5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate
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Thumb → Thumb
5-Phosphoribosyl-5-carboxyaminoimidazole → 5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate
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PseudoCyc/BioCyc Reactions:
Thumb ↔ Thumb
5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate ↔ 5-Phosphoribosyl-5-carboxyaminoimidazole
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5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole+Thumb ↔ Thumb
5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole + 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole ↔ 5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate
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Thumb → Thumb
5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole → 5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate
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Thumb ↔ Thumb+Thumb
5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate ↔ 5-Aminoimidazole ribonucleotide + Carbon dioxide
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N5-Carboxyaminoimidazole ribonucleotide+Thumb → Thumb
N5-Carboxyaminoimidazole ribonucleotide + N5-Carboxyaminoimidazole ribonucleotide → 5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate
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Thumb
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + 2 H+ = 5-amino-1-(5-phospho-β-D-ribosyl)imidazole + CO2
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Complex Reactions:
Thumb ↔ Thumb
5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate ↔ 5-Phosphoribosyl-5-carboxyaminoimidazole
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Thumb → Thumb
5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole → 5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate
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Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB0006635-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylateMetaboCard
PAMDB0034105-carboxyamino-1-(5-phospho-D-ribosyl)imidazoleMetaboCard
PAMDB0015875-Phosphoribosyl-5-carboxyaminoimidazoleMetaboCard
PAMDB000337N5-Carboxyaminoimidazole ribonucleotideMetaboCard
GO Classification:
Function
carbon-carbon lyase activity
carboxy-lyase activity
catalytic activity
lyase activity
phosphoribosylaminoimidazole carboxylase activity
Process
'de novo' IMP biosynthetic process
cellular nitrogen compound metabolic process
IMP biosynthetic process
metabolic process
nitrogen compound metabolic process
nucleobase, nucleoside and nucleotide metabolic process
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
nucleoside phosphate metabolic process
nucleotide metabolic process
purine nucleoside monophosphate biosynthetic process
purine nucleotide biosynthetic process
purine nucleotide metabolic process
purine ribonucleoside monophosphate biosynthetic process
Gene Properties
Locus tag: PA5426
Strand: -
Entrez Gene ID: 877624
Accession: NP_254113.1
GI: 15600619
Sequence start: 6106272
Sequence End: 6106763
Sequence Length: 491
Gene Sequence: 
>PA5426
ATGAGCGCACTGGTTGGCGTGATCATGGGTTCCAAATCGGACTGGAGCACCCTCAGTCACACCGCGGACATGCTGGACAAGCTGGGCATCCCCTACGAAGTGAAGGTGGTTTCCGCCCACCGCACCCCGGACCTGCTCTTCCAGTACGCCGAGGAAGCCGAAGGCCGCGGCCTCGAAGTGATCATCGCCGGCGCTGGCGGCGCCGCCCACCTGCCGGGCATGTGCGCGGCCAAGACCCACCTGCCGGTACTCGGCGTGCCGGTACAGTCGTCGATGCTGTCGGGTGTCGACTCGCTGCTCTCCATCGTGCAGATGCCCGCCGGCGTACCGGTCGCCACCCTGGCCATCGGCAAGGCCGGCGCGGTCAACGCGGCGCTGCTCTCGGCGAGCATCCTCGGCGCCAAGCACCCGCAGTACCACGAGGCGCTGAAGCAGTTCCGCGCCAACCAGACCGAAACCGTGCTGGACAATCCCGACCCGCGCGATGCGTGA
Protein Properties
Protein Residues: 163
Protein Molecular Weight: 16.9 kDa
Protein Theoretical pI: 6.23
Hydropathicity (GRAVY score): 0.227
Charge at pH 7 (predicted): -2.6
Protein Sequence: 
>PA5426
MSALVGVIMGSKSDWSTLSHTADMLDKLGIPYEVKVVSAHRTPDLLFQYAEEAEGRGLEVIIAGAGGAAHLPGMCAAKTHLPVLGVPVQSSMLSGVDSLLSIVQMPAGVPVATLAIGKAGAVNAALLSASILGAKHPQYHEALKQFRANQTETVLDNPDPRDA
References
External Links:
Resource Link
Genome ID: PA5426
Entrez Gene ID: 877624
NCBI Protein ID: 15600619
General Reference: PaperBLAST - Find papers about PA5426 and its homologs