Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha (PA3639)

Identification
Name: Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha
Synonyms:
  • ACCase subunit alpha
  • Acetyl-CoA carboxylase carboxyltransferase subunit alpha
Gene Name: accA
Enzyme Class:
Biological Properties
General Function: Involved in acetyl-CoA carboxylase activity
Specific Function: Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA
Cellular Location: Cytoplasm
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb+Thumb ↔ Thumb+Thumb+Thumb+Thumb
Acetyl-CoA + Adenosine triphosphate + Hydrogen carbonate ↔ ADP + Hydrogen ion + Malonyl-CoA + Phosphate
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Thumb+Thumb+Thumb ↔ Thumb+Thumb+Thumb
Adenosine triphosphate + Acetyl-CoA + Hydrogen carbonate ↔ ADP + Phosphate + Malonyl-CoA
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Thumb+Carboxybiotin-carboxyl-carrier protein ↔ Thumb+Holo-[carboxylase]
Acetyl-CoA + Carboxybiotin-carboxyl-carrier protein ↔ Malonyl-CoA + Holo-[carboxylase]
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SMPDB Reactions:
Thumb+Thumb+Thumb → Adenosine diphosphate+Thumb+Thumb+Malonyl-CoA+Thumb+Thumb
Acetyl-CoA + Hydrogen carbonate + Adenosine triphosphate → Adenosine diphosphate + Phosphate + Hydrogen ion + Malonyl-CoA + ADP + Malonyl-CoA
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a biotinylated [BCCP dimer]+Thumb+Thumb → carboxylated-biotinylated [BCCP dimer]+Thumb+Thumb+Thumb
a biotinylated [BCCP dimer] + Adenosine triphosphate + Hydrogen carbonate → carboxylated-biotinylated [BCCP dimer] + Hydrogen ion + ADP + Phosphate
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PseudoCyc/BioCyc Reactions:
Thumb+Thumb+Thumb ↔ Thumb+Thumb+Thumb+Thumb
Acetyl-CoA + Adenosine triphosphate + Hydrogen carbonate ↔ ADP + Hydrogen ion + Malonyl-CoA + Phosphate
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Complex Reactions:
Thumb+Thumb+Thumb → Thumb+Thumb+Thumb
Adenosine triphosphate + Acetyl-CoA + Carbonic acid → ADP + Inorganic phosphate + Malonyl-CoA
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Thumb+Thumb+Thumb → Thumb+Thumb+Thumb
Adenosine triphosphate + Acetyl-CoA + Carbonic acid → ADP + Inorganic phosphate + Malonyl-CoA
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Thumb+Thumb+Thumb → Thumb+Thumb+Thumb
Adenosine triphosphate + Acetyl-CoA + Carbonic acid → ADP + Inorganic phosphate + Malonyl-CoA
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Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB000298Acetyl-CoAMetaboCard
PAMDB000148Adenosine triphosphateMetaboCard
PAMDB000345ADPMetaboCard
PAMDB000510Carbonic acidMetaboCard
PAMDB000153Hydrogen carbonateMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB001776Inorganic phosphateMetaboCard
PAMDB000284Malonyl-CoAMetaboCard
PAMDB000383PhosphateMetaboCard
GO Classification:
Component
acetyl-CoA carboxylase complex
macromolecular complex
protein complex
Function
acetyl-CoA carboxylase activity
catalytic activity
CoA carboxylase activity
ligase activity
ligase activity, forming carbon-carbon bonds
Process
carboxylic acid metabolic process
cellular metabolic process
fatty acid biosynthetic process
fatty acid metabolic process
metabolic process
monocarboxylic acid metabolic process
organic acid metabolic process
oxoacid metabolic process
Gene Properties
Locus tag: PA3639
Strand: -
Entrez Gene ID: 880489
Accession: NP_252329.1
GI: 15598835
Sequence start: 4074057
Sequence End: 4075007
Sequence Length: 950
Gene Sequence: 
>PA3639
ATGAACCCGAACTTTCTTGATTTCGAACAGCCGATCGCCGACCTGCAAGCCAAGATCGAAGAGCTGCGCCTGGTGGGCAACGACAATGCGCTGAACATCAGCGACGAAATCTCGCGTCTGCAGGACAAGAGCAAGGCGCTCACCGAAAACATCTTCGGCAATCTGTCCAGTTGGCAGATCGCCCAGCTCGCGCGCCATCCCAAGCGTCCCTATACCCTCGACTACATCGGCTACCTGTTCAGCGATTTCGAGGAACTGCACGGCGACCGGCATTTCGCCGACGACCCGGCGATCGTCGGCGGCGTTGCCCGCCTCGACGGTTCCCCGGTGATGGTCATCGGCCACCAGAAGGGCCGCGAAGTCCGTGAGAAGGTCCGGCGCAACTTCGGCATGCCGCGTCCGGAAGGCTATCGCAAGGCCTGCCGCCTGATGGAAATGGCCGAACGCTTCAAGATGCCGATCCTCACCTTCATCGACACGCCCGGCGCCTACCCGGGGATCGATGCCGAGGAACGCGGCCAGAGCGAGGCGATCGCCTGGAACCTGCGGGTGATGGCGCGACTGAAGACGCCGATCATCGCCACCGTGATCGGCGAGGGCGGTTCCGGCGGCGCGCTGGCCATCGGTGTCTGCGACCAGTTGAACATGCTGCAATACTCCACCTATTCGGTGATCTCGCCGGAAGGCTGCGCCTCCATCCTCTGGAAGACCGCCGAGAAGGCGCCGGAAGCCGCCGAGGCCATGGGCATCACCGCCGAGCGCCTGAAAGGCCTGGGCATCGTCGACAAGGTCATCGACGAACCGCTGGGCGGCGCCCATCGCGATCCGGCGAGCATGGCCGAATCGATCCGTGGCGAACTGCTGGCGCAACTGAAGATGCTCCAGGGCCTGGAAATGGGTGAGTTGCTGGAGCGTCGTTACGACCGCCTGATGAGCTACGGCGCGCCGTAA
Protein Properties
Protein Residues: 316
Protein Molecular Weight: 34.9 kDa
Protein Theoretical pI: 5.15
Hydropathicity (GRAVY score): -0.269
Charge at pH 7 (predicted): -6.88
Protein Sequence: 
>PA3639
MNPNFLDFEQPIADLQAKIEELRLVGNDNALNISDEISRLQDKSKALTENIFGNLSSWQIAQLARHPKRPYTLDYIGYLFSDFEELHGDRHFADDPAIVGGVARLDGSPVMVIGHQKGREVREKVRRNFGMPRPEGYRKACRLMEMAERFKMPILTFIDTPGAYPGIDAEERGQSEAIAWNLRVMARLKTPIIATVIGEGGSGGALAIGVCDQLNMLQYSTYSVISPEGCASILWKTAEKAPEAAEAMGITAERLKGLGIVDKVIDEPLGGAHRDPASMAESIRGELLAQLKMLQGLEMGELLERRYDRLMSYGAP
References
External Links:
Resource Link
Genome ID: PA3639
Entrez Gene ID: 880489
NCBI Protein ID: 15598835
General Reference: PaperBLAST - Find papers about PA3639 and its homologs