| Identification |
| Name: |
Glutamyl-tRNA synthetase |
| Synonyms: |
- Glutamate--tRNA ligase
- GluRS
|
| Gene Name: |
gltX |
| Enzyme Class: |
|
| Biological Properties |
| General Function: |
Involved in nucleotide binding |
| Specific Function: |
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction:glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) |
| Cellular Location: |
Cytoplasm |
| KEGG Pathways: |
|
| KEGG Reactions: |
|
tRNA(Glu) | + |  | + |  | + | tRNA(Glu) | ↔ | L-Glutamyl-tRNA(Glu) | + |  | + |  | + |  |
| |
|
| SMPDB Reactions: |
|
L-Glutamic acid | + | | + |  | + | tRNA(Glu) | + | | → | Pyrophosphate | + | | + | L-glutamyl-tRNA(Glu) |
| | |
8 L-Glutamic acid | + | 8 | + | 8 | + | 8 tRNA(Glu) | + | 8 | → | 8 | + | 8 Pyrophosphate | + | 8 L-glutamyl-tRNA(Glu) |
| |
|
| PseudoCyc/BioCyc Reactions: |
|
| Complex Reactions: |
|
| + | | + | tRNA (Glu) | → | | + | L-Glutamyl-tRNA(Glu) | + | |
| | |
| + | | + | tRNA(Glu) | → | | + | | + | L-glutamyl-tRNA(Glu) |
| |
|
| Transports: |
Not Available |
| Metabolites: |
|
| GO Classification: |
| Component |
|---|
| cell part | | cytoplasm | | intracellular part | | Function |
|---|
| adenyl nucleotide binding | | adenyl ribonucleotide binding | | aminoacyl-tRNA ligase activity | | ATP binding | | binding | | catalytic activity | | glutamate-tRNA ligase activity | | ligase activity | | ligase activity, forming aminoacyl-tRNA and related compounds | | ligase activity, forming carbon-oxygen bonds | | nucleoside binding | | nucleotide binding | | purine nucleoside binding | | Process |
|---|
| biosynthetic process | | cellular macromolecule biosynthetic process | | cellular macromolecule metabolic process | | glutamyl-tRNA aminoacylation | | macromolecule biosynthetic process | | macromolecule metabolic process | | metabolic process | | ncRNA metabolic process | | RNA metabolic process | | translation | | tRNA aminoacylation | | tRNA aminoacylation for protein translation | | tRNA metabolic process |
|
| Gene Properties |
| Locus tag: |
PA3134 |
| Strand: |
- |
| Entrez Gene ID: |
882647 |
| Accession: |
NP_251824.1 |
| GI: |
15598330 |
| Sequence start: |
3515416 |
| Sequence End: |
3516900 |
| Sequence Length: |
1484 |
| Gene Sequence: |
>PA3134
ATGACCACTGTTCGTACTCGCATCGCCCCGTCGCCGACGGGCGACCCGCACGTCGGTACCGCATACATCGCGCTGTTCAACCTGTGCTTCGCGCGTCAGCACGGCGGTCAGTTCATCCTGCGCATCGAGGACACCGACCAGCTGCGTTCGACGCGGGAGTCCGAGCAGCAGATCTACGACGCCCTGCGCTGGCTCGGCATCGAATGGGACGAGGGCCCGGACGTCGGCGGCCCGCATGGCCCGTACCGGCAGAGCGAGCGCGGGCATATCTACAAGAAGTATTCGGACGAACTGGTCGAGAAGGGCCATGCCTTCACCTGCTTCTGCACGCCCGAGCGCCTCGATGCGGTTCGCGCCGAGCAGATGGCGCGTAAGGAAACCCCGCGCTACGACGGCCACTGCATGCACCTGCCGAAGGATGAGGTGCAGCGCCGCCTCGCCGCCGGCGAGTCCCACGTCACCCGCATGAAGGTGCCGACCGAGGGCGTCTGCGTGGTGCCGGACATGCTCCGCGGCGATGTCGAGATTCCGTGGGATCGCATGGACATGCAGGTGCTGATGAAGGCCGACGGCCTGCCCACCTACTTCCTCGCCAACGTGGTCGACGACCACCTGATGGGCATCACCCACGTCCTGCGCGGCGAAGAGTGGCTGCCGTCGGCGCCCAAGCTGATCAAGCTCTACGAGTATTTCGGCTGGGAGCAGCCGCAGCTGTGCTACATGCCACTGCTGCGCAACCCGGACAAGAGCAAGCTGTCCAAGCGCAAGAACCCGACCTCTATCACCTTCTACGAGCGCATGGGCTACCTGCCGCAGGCGCTGCTCAACTACCTCGGGCGGATGGGCTGGTCGATGCCGGACGAGCGCGAGAAATTCACCCTCGCCGAGATGATCGAGCATTTCGACCTGTCGCGCGTCTCCCTGGGCGGACCGATCTTCGACCTGGAGAAGCTCTCCTGGCTGAACGGGCAGTGGATCCGCGAGCAGTCCGTGGAGGAGTTCGCCCGTGAGGTGCAGAAGTGGGCGTTGAATCCCGAATACCTGATGAAGATCGCTCCGCACGTGCAGGGACGGGTGGAGAACTTCAGCCAGATCGCGCCGCTGGCCGGATTCTTCTTCAGCGGCGGGGTGCCGCTGGACGCTTCGCTGTTCGAACACAAGAAGCTCGATCCGACCCAGGTCCGCCAGGTCCTGCAACTGGTGCTGTGGAAACTCGAATCCCTGCGCCAGTGGGAGAAGGAACGCATCACCGGCTGCATCCAGGCTGTCGCCGAACACCTCCAGCTCAAGCTGCGCGACGTGATGCCGCTGATGTTCCCGGCCATCACCGGGCATGCCAGCTCGGTTTCGGTGCTGGACGCCATGGAGATCCTTGGCGCCGACCTGTCGCGTTATCGCTTGCGCCAGGCCCTGGAGCTGCTGGGCGGGGCGTCGAAAAAGGAAACCAAGGAGTGGGAGAAGATCCGCGACGCCATTCCCGGCTGA |
| Protein Properties |
| Protein Residues: |
494 |
| Protein Molecular Weight: |
56.7 kDa |
| Protein Theoretical pI: |
6.68 |
| Hydropathicity (GRAVY score): |
-0.405 |
| Charge at pH 7 (predicted): |
-2.58 |
| Protein Sequence: |
>PA3134
MTTVRTRIAPSPTGDPHVGTAYIALFNLCFARQHGGQFILRIEDTDQLRSTRESEQQIYDALRWLGIEWDEGPDVGGPHGPYRQSERGHIYKKYSDELVEKGHAFTCFCTPERLDAVRAEQMARKETPRYDGHCMHLPKDEVQRRLAAGESHVTRMKVPTEGVCVVPDMLRGDVEIPWDRMDMQVLMKADGLPTYFLANVVDDHLMGITHVLRGEEWLPSAPKLIKLYEYFGWEQPQLCYMPLLRNPDKSKLSKRKNPTSITFYERMGYLPQALLNYLGRMGWSMPDEREKFTLAEMIEHFDLSRVSLGGPIFDLEKLSWLNGQWIREQSVEEFAREVQKWALNPEYLMKIAPHVQGRVENFSQIAPLAGFFFSGGVPLDASLFEHKKLDPTQVRQVLQLVLWKLESLRQWEKERITGCIQAVAEHLQLKLRDVMPLMFPAITGHASSVSVLDAMEILGADLSRYRLRQALELLGGASKKETKEWEKIRDAIPG |
| References |
| External Links: |
|
| General Reference: |
PaperBLAST - Find papers about PA3134 and its homologs
|
