P. aeruginosa Metabolome Database Protein PA3111

Identification

Name:

Bifunctional protein folC

Synonyms:

Folylpolyglutamate synthase
Folylpoly-gamma-glutamate synthetase
FPGS
Tetrahydrofolylpolyglutamate synthase
Tetrahydrofolate synthase
Dihydrofolate synthase

Gene Name:

folC

Enzyme Class:

Biological Properties

General Function:

Involved in tetrahydrofolylpolyglutamate synthase activity

Specific Function:

Conversion of folates to polyglutamate derivatives

Cellular Location:

Not Available

KEGG Pathways:

Folate biosynthesis pae00790
Metabolic pathways pae01100

KEGG Reactions:

↔

Adenosine triphosphate + 7,8-Dihydropteroic acid + L-Glutamate ↔ ADP + Dihydrofolic acid + Hydrogen ion + Phosphate
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↔

Adenosine triphosphate + Tetrahydrofolic acid + L-Glutamate ↔ ADP + Phosphate + Tetrahydrofolyl-[Glu](2)
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↔

Adenosine triphosphate + 7,8-Dihydropteroic acid + L-Glutamate ↔ ADP + Phosphate + Dihydrofolic acid
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↔

Adenosine triphosphate + THF-polyglutamate + L-Glutamate ↔ ADP + Phosphate
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SMPDB Reactions:

L-Glutamic acid

→

Adenosine diphosphate

7,8-dihydrofolate monoglutamate

7,8-Dihydropteroic acid + Adenosine triphosphate + L-Glutamic acid + L-Glutamate → Adenosine diphosphate + Phosphate + Hydrogen ion + 7,8-dihydrofolate monoglutamate + ADP + Dihydrofolic acid
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PseudoCyc/BioCyc Reactions:

↔

Adenosine triphosphate + 7,8-Dihydropteroic acid + L-Glutamate ↔ ADP + Dihydrofolic acid + Hydrogen ion + Phosphate
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→

L-Glutamate + 7,8-Dihydropteroic acid + Adenosine triphosphate → Hydrogen ion + Dihydrofolic acid + Phosphate + ADP
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a tetrahydrofolate-glutamate

→

a tetrahydrofolate-glutamate

a tetrahydrofolate-glutamate + L-Glutamate + Adenosine triphosphate → a tetrahydrofolate-glutamate + Phosphate + ADP
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an N¹⁰-formyl-tetrahydrofolate

→

an N¹⁰-formyl-tetrahydrofolate

an N¹⁰-formyl-tetrahydrofolate + L-Glutamate + Adenosine triphosphate → an N¹⁰-formyl-tetrahydrofolate + ADP + Phosphate
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a 5,10-methylene-tetrahydrofolate

→

a 5,10-methylene-tetrahydrofolate

a 5,10-methylene-tetrahydrofolate + L-Glutamate + Adenosine triphosphate → a 5,10-methylene-tetrahydrofolate + Phosphate + ADP
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Complex Reactions:

tetrahydropteroyl-(gamma-Glu)(n)

→

tetrahydropteroyl-(gamma-Glu)(n+1)

Adenosine triphosphate + tetrahydropteroyl-(gamma-Glu)(n) + L-Glutamate → ADP + Inorganic phosphate + tetrahydropteroyl-(gamma-Glu)(n+1)
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→

Adenosine triphosphate + 7,8-Dihydropteroic acid + L-Glutamate → ADP + Inorganic phosphate + Dihydrofolic acid
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Transports:

Not Available

Metabolites:

PAMDB ID	Name	View
PAMDB000376	7,8-Dihydropteroic acid	MetaboCard
PAMDB000148	Adenosine triphosphate	MetaboCard
PAMDB000345	ADP	MetaboCard
PAMDB000235	Dihydrofolic acid	MetaboCard
PAMDB001633	Hydrogen ion	MetaboCard
PAMDB001776	Inorganic phosphate	MetaboCard
PAMDB000055	L-Glutamate	MetaboCard
PAMDB000383	Phosphate	MetaboCard
PAMDB000424	Tetrahydrofolic acid	MetaboCard
PAMDB002051	Tetrahydrofolyl-[Glu](2)	MetaboCard

GO Classification:

Function
acid-amino acid ligase activity
adenyl nucleotide binding
adenyl ribonucleotide binding
ATP binding
binding
catalytic activity
ligase activity
ligase activity, forming carbon-nitrogen bonds
nucleoside binding
purine nucleoside binding
tetrahydrofolylpolyglutamate synthase activity
Process
biosynthetic process
cellular aromatic compound metabolic process
cellular metabolic process
folic acid and derivative biosynthetic process
folic acid and derivative metabolic process
metabolic process

Gene Properties

Locus tag:

PA3111

Strand:

Entrez Gene ID:

879056

Accession:

NP_251801.1

GI:

15598307

Sequence start:

3491415

Sequence End:

3492704

Sequence Length:

1289

Gene Sequence:

>PA3111
ATGACCCAGCGTTCCCTGGCCGATTGGCTGAGCTATCTCGAACAACTCCATCCGACGGCCATCGACATGGGCCTGGAGCGTTCCCGCGAGGTAGCGCGCCGGCTCGGCCTGGGAAGGCCGGCGAAACGCGTGGTCACCGTTACCGGGACCAACGGCAAGGGCTCCACCTGCGCCCTGCTCGCCGAACTGCTGCGTGAGCAGGGGTTGTCGGTCGGGGTCTACAGCTCGCCGCACCTGCTGCGCTACAACGAGCGGGTGCGGATCGACGGCATCGAGGCCGGCGATGCGCAACTGTGCGACGCCTTCTCCGCGGTGGAGGCCGCACGTGGCGAGATTTCCCTGACCTATTTCGAAATGGGCACGCTGGCCGCCTTCTGGCTGTTCGAGCGCGCCGGGCTGGACTTCGCGGTGCTGGAAGTCGGCCTTGGCGGGCGCCTGGATGCGGTCAACCTGATCGACGCCGACCTGGCGCTGATCACCAGCATCGGCCTGGACCATGCGGACTGGCTGGGCGATACCCGCGAAAGCGTGGCTTTCGAGAAAGCCGGTATCCTGCGCGCCGGCAAACCGGCCCTGTGCGGCGATCTCGATCCCCCGCAGCCATTGCTGGAGCAGGTGGCTGCGCTGGGGGCACCGCTTTACCTGCGCGGTCGCGACTACGACCTGGCGCTCGCCGATCATGGCTGGCACTGGCGCGGGCTGGCCGCGGACGGCCAGGCGCTGGCGCTGCACGATCTGCCGTTGCTCGGGTTGCCCATGGAAAACGCCGCGCTGGCCCTGCAGGCCTACGCGTTGCTCGAGTTGCCCTGGCAGGCGGAGCGCCTGGCCGAGGCGCTGCGGCGGACCCGGGTGACCGGTCGCCTCGATCGCCGCGACCTGTCCTGGAACGGCCAGCCACGCCAGCTCCTGCTGGACGTCGGGCACAATCCCCAGGCCGCCCAGTACCTGGCGCAACGCCTGCGTGCCGCAGCGCCACGAGGACGCTACCTGGCGGTCTTCGGCCTGCTGGCGGACAAAGACCTGGATGGCGTACTGGAACCCTTGACCGGCTTGGTGCAGGATTGGGCCGTTGCACCGTTGCCGACCCCGCGTTCGCGGCCGGCCGCGGAGCTGGAGGCGGCGCTGATCCTGCGCCAGGTTCCGGCGAGCAGTCATGCGGATATCGCCGCCGCCCTGGACGCGCAGTGCGCCAAGGCTACCGCGGATGATGTCATTCTGCTGTTCGGATCGTTCTATAGCGTGGCCGAAGGCCTGGAATGGCTGGCCCGTAGAACGGATAAGGGGGAGTAA

Protein Properties

Protein Residues:

429

Protein Molecular Weight:

46.5 kDa

Protein Theoretical pI:

4.99

Hydropathicity (GRAVY score):

0.001

Charge at pH 7 (predicted):

-11.18

Protein Sequence:

>PA3111
MTQRSLADWLSYLEQLHPTAIDMGLERSREVARRLGLGRPAKRVVTVTGTNGKGSTCALLAELLREQGLSVGVYSSPHLLRYNERVRIDGIEAGDAQLCDAFSAVEAARGEISLTYFEMGTLAAFWLFERAGLDFAVLEVGLGGRLDAVNLIDADLALITSIGLDHADWLGDTRESVAFEKAGILRAGKPALCGDLDPPQPLLEQVAALGAPLYLRGRDYDLALADHGWHWRGLAADGQALALHDLPLLGLPMENAALALQAYALLELPWQAERLAEALRRTRVTGRLDRRDLSWNGQPRQLLLDVGHNPQAAQYLAQRLRAAAPRGRYLAVFGLLADKDLDGVLEPLTGLVQDWAVAPLPTPRSRPAAELEAALILRQVPASSHADIAAALDAQCAKATADDVILLFGSFYSVAEGLEWLARRTDKGE

References

External Links:

Resource	Link
Genome ID:	PA3111
Entrez Gene ID:	879056
NCBI Protein ID:	15598307

General Reference:

PaperBLAST - Find papers about PA3111 and its homologs

Bifunctional protein folC (PA3111)