Aromatic-amino-acid aminotransferase (PA3139)

Identification
Name: Aromatic-amino-acid aminotransferase
Synonyms:
  • ARAT
  • AROAT
Gene Name: tyrB
Enzyme Class:
Biological Properties
General Function: Involved in transferase activity
Specific Function: An aromatic amino acid + 2-oxoglutarate = an aromatic oxo acid + L-glutamate
Cellular Location: Cytoplasm
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb ↔ Thumb+Thumb
alpha-Ketoglutarate + L-Phenylalanine ↔ L-Glutamate + Phenylpyruvic acid
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Thumb+Thumb ↔ Thumb+Thumb
alpha-Ketoglutarate + L-Tyrosine ↔ 4-Hydroxyphenylpyruvic acid + L-Glutamate
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Thumb+Thumb ↔ Thumb+Thumb
L-Phenylalanine + alpha-Ketoglutarate ↔ Phenylpyruvic acid + L-Glutamate
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Thumb+Thumb ↔ Thumb+Thumb
L-Tyrosine + alpha-Ketoglutarate ↔ 4-Hydroxyphenylpyruvic acid + L-Glutamate
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Thumb+Thumb ↔ Thumb+Thumb
2-Oxo-4-methylthiobutanoic acid + L-Glutamate ↔ L-Methionine + alpha-Ketoglutarate
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Thumb+Thumb ↔ Thumb+Thumb
Aromatic amino acid + alpha-Ketoglutarate ↔ Aromatic oxo acid + L-Glutamate
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SMPDB Reactions:
4-hydroxyphenylpyruvate+L-Glutamic acid+Thumb → Thumb+L-Tyrosine+Thumb
4-hydroxyphenylpyruvate + L-Glutamic acid + L-Glutamate → Oxoglutaric acid + L-Tyrosine + L-Tyrosine
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Thumb+L-Glutamic acid+Thumb → Thumb+Thumb
Ketoleucine + L-Glutamic acid + L-Glutamate → Oxoglutaric acid + L-Leucine
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L-Phenylalanine+Thumb+Thumb ↔ Thumb+Thumb
L-Phenylalanine + Oxygen + L-Phenylalanine ↔ Oxoglutaric acid + Phenylpyruvic acid
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PseudoCyc/BioCyc Reactions:
Thumb+Thumb → Thumb+Thumb
Ketoleucine + L-Glutamate → alpha-Ketoglutarate + L-Leucine
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Thumb+Thumb ↔ Thumb+Thumb
alpha-Ketoglutarate + L-Phenylalanine ↔ L-Glutamate + Phenylpyruvic acid
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Thumb+Thumb ↔ Thumb+Thumb
alpha-Ketoglutarate + L-Tyrosine ↔ 4-Hydroxyphenylpyruvic acid + L-Glutamate
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Thumb+Thumb ↔ Thumb+Thumb
L-Tyrosine + alpha-Ketoglutarate ↔ 4-Hydroxyphenylpyruvic acid + L-Glutamate
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Thumb+Thumb ↔ Thumb+Thumb
L-Phenylalanine + alpha-Ketoglutarate ↔ Phenylpyruvic acid + L-Glutamate
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Thumb+Thumb ↔ Thumb+Thumb
2-Oxo-4-methylthiobutanoic acid + L-Glutamate ↔ L-Methionine + alpha-Ketoglutarate
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An aromatic amino acid+Thumb → an aromatic oxo acid+Thumb
An aromatic amino acid + Oxoglutaric acid → an aromatic oxo acid + L-Glutamate
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Thumb+Thumb ↔ Thumb+Thumb
Aromatic amino acid + alpha-Ketoglutarate ↔ Aromatic oxo acid + L-Glutamate
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4-hydroxyphenylpyruvate+L-Glutamic acid+Thumb → Thumb+L-Tyrosine+Thumb
4-hydroxyphenylpyruvate + L-Glutamic acid + L-Glutamate → Oxoglutaric acid + L-Tyrosine + L-Tyrosine
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Thumb+L-Glutamic acid+Thumb → Thumb+Thumb
Ketoleucine + L-Glutamic acid + L-Glutamate → Oxoglutaric acid + L-Leucine
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L-Phenylalanine+Thumb+Thumb ↔ Thumb+Thumb
L-Phenylalanine + Oxygen + L-Phenylalanine ↔ Oxoglutaric acid + Phenylpyruvic acid
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PAMDB000061+PAMDB000466 → PAMDB110745+PAMDB110666
L-Phenylalanine + alpha-Ketoglutarate → 2-oxo-3-phenylpropanoate + L-glutamate
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Aromatic-Amino-Acids+PAMDB000466 → Aromatic-Oxoacids+PAMDB110666
Aromatic-Amino-Acids + alpha-Ketoglutarate → Aromatic-Oxoacids + L-glutamate
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PAMDB000175+PAMDB000466 → PAMDB120327+PAMDB110666
L-Methionine + alpha-Ketoglutarate → 2-oxo-4-methylthiobutanoate + L-glutamate
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Complex Reactions:
Thumb+Thumb → Thumb+Thumb
Ketoleucine + L-Glutamate → alpha-Ketoglutarate + L-Leucine
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An aromatic amino acid+Thumb → an aromatic oxo acid+Thumb
An aromatic amino acid + Oxoglutaric acid → an aromatic oxo acid + L-Glutamate
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Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB0004182-Oxo-4-methylthiobutanoic acidMetaboCard
PAMDB0001764-Hydroxyphenylpyruvic acidMetaboCard
PAMDB000466alpha-KetoglutarateMetaboCard
PAMDB000174KetoleucineMetaboCard
PAMDB000080L-Aspartic acidMetaboCard
PAMDB000055L-GlutamateMetaboCard
PAMDB000170L-LeucineMetaboCard
PAMDB000175L-MethionineMetaboCard
PAMDB000061L-PhenylalanineMetaboCard
PAMDB000060L-TyrosineMetaboCard
PAMDB000092Oxalacetic acidMetaboCard
PAMDB000623Oxoglutaric acidMetaboCard
PAMDB000624OxygenMetaboCard
PAMDB000084Phenylpyruvic acidMetaboCard
PAMDB000839PrephenateMetaboCard
GO Classification:
Function
binding
catalytic activity
cofactor binding
pyridoxal phosphate binding
transaminase activity
transferase activity
transferase activity, transferring nitrogenous groups
Process
biosynthetic process
cellular amino acid and derivative metabolic process
cellular amino acid metabolic process
cellular metabolic process
metabolic process
Gene Properties
Locus tag: PA3139
Strand: +
Entrez Gene ID: 882671
Accession: NP_251829.1
GI: 15598335
Sequence start: 3522748
Sequence End: 3523944
Sequence Length: 1196
Gene Sequence: 
>PA3139
ATGAGTCTGTTTTCTGCCGTCGAAATGGCACCGCGTGATCCCATCCTTGGCCTGAACGAAGCCTTCAACGCCGATACCCGTCCGGGCAAGATCAACCTGGGCGTGGGCGTGTACTACAACGAGGAGGGGCGCATTCCGCTGTTGCGTGCCGTGCAGGCTGCCGAGAAGGCCCGCATCGAGGCCCACGCGCCGCGCGGCTACCTGCCGATCGAAGGGATCGCCGCCTACGACCAGGGCGTACAGAAACTGCTGTTCGGTAACGAGTCCGAGCTGCTGGCCGCCGGCCGTGTGGTCACGACCCAGGCCGTCGGCGGCACCGGCGCGCTCAAGCTCGGCGCCGACTTCCTCAAGCGCCTGCTGCCCGACGCCACCGTGGCCATCAGCGACCCGAGCTGGGAAAACCACCGCGCACTGTTCGAAGCCGCCGGCTTCCCGGTGCAGAACTACCGCTATTACGACGCCGCCAGCAATGGCGTGAACCGCGCCGGCCTGCTGGAAGACCTGAATGCCCTGCCGGCCCGCTCGATCGTGGTTCTGCACGCCTGCTGCCATAATCCGACCGGCGTCGATCTCGAGCTGGACGACTGGAAACAGGTGCTGGACGTGCTCAAGGCCAAGGGCCACGTGCCGTTCCTCGACATCGCCTACCAGGGCTTCGGCAACGGCATCGAGGAAGACGCCGCCGCGGTGCGCCTGTTCGCCCAGTCGGGCCTGAGCTTCTTCGTTTCCAGCTCGTTCTCCAAATCCTTCTCGCTCTATGGCGAACGCGTCGGCGCCCTCTCGATCGTGACCGAAAGCCGCGATGAATCGGCCCGCGTGCTGTCCCAGGTGAAGCGGGTGATCCGCACCAACTATTCGAACCCACCGACCCACGGCGCCAGCGTCGTCTCCTCCGTGCTCAACAGCCCGGAACTGCGGGCCCTCTGGGAGCAGGAACTGGGCGAGATGCGCGACCGCATCCGCGACATGCGCCTGGCGATGGTCGAGCAACTGGCAGCCCACGGCGCCAAGCGCGACTTCAGCTTCGTCGGTCGCCAACGTGGCATGTTCTCCTATTCCGGCCTGACCGCCGACCAGGTCGAGCGCCTGAAGACCGAGTTCGGTATCTACGCCGTCAGCACCGGCCGTATCTGCGTCGCCGCGCTGAACAAATCGAACCTGGAGACCATCACCAAGGCCATCGTCCAGGTCCTGTAG
Protein Properties
Protein Residues: 398
Protein Molecular Weight: 43.3 kDa
Protein Theoretical pI: 6.64
Hydropathicity (GRAVY score): -0.06
Charge at pH 7 (predicted): -1.4
Protein Sequence: 
>PA3139
MSLFSAVEMAPRDPILGLNEAFNADTRPGKINLGVGVYYNEEGRIPLLRAVQAAEKARIEAHAPRGYLPIEGIAAYDQGVQKLLFGNESELLAAGRVVTTQAVGGTGALKLGADFLKRLLPDATVAISDPSWENHRALFEAAGFPVQNYRYYDAASNGVNRAGLLEDLNALPARSIVVLHACCHNPTGVDLELDDWKQVLDVLKAKGHVPFLDIAYQGFGNGIEEDAAAVRLFAQSGLSFFVSSSFSKSFSLYGERVGALSIVTESRDESARVLSQVKRVIRTNYSNPPTHGASVVSSVLNSPELRALWEQELGEMRDRIRDMRLAMVEQLAAHGAKRDFSFVGRQRGMFSYSGLTADQVERLKTEFGIYAVSTGRICVAALNKSNLETITKAIVQVL
References
External Links:
Resource Link
Genome ID: PA3139
Entrez Gene ID: 882671
NCBI Protein ID: 15598335
General Reference: PaperBLAST - Find papers about PA3139 and its homologs