Phosphoribosylglycinamide formyltransferase 2 (PA3751)

Identification
Name: Phosphoribosylglycinamide formyltransferase 2
Synonyms:
  • GART 2
  • 5'-phosphoribosylglycinamide transformylase 2
  • Formate-dependent GAR transformylase
  • GAR transformylase 2
Gene Name: purT
Enzyme Class:
Biological Properties
General Function: Involved in ATP binding
Specific Function: Catalyzes two reactions:the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR; the second, a side reaction, is the production of acetyl phosphate and ADP from acetate and ATP
Cellular Location: Not Available
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb ↔ Thumb+Thumb
Acetic acid + Adenosine triphosphate ↔ Acetylphosphate + ADP
ReactionCard
Thumb+Thumb ↔ Thumb+Thumb+Thumb
N10-Formyl-THF + Glycineamideribotide ↔ 5'-Phosphoribosyl-N-formylglycineamide + Hydrogen ion + Tetrahydrofolic acid
ReactionCard
Thumb+Thumb ↔ Thumb+Thumb
N10-Formyl-THF + Glycineamideribotide ↔ Tetrahydrofolic acid + 5'-Phosphoribosyl-N-formylglycineamide
ReactionCard
Thumb+Thumb+Thumb ↔ Thumb+Thumb
Glycineamideribotide + 5,10-Methenyltetrahydrofolate + Water ↔ 5'-Phosphoribosyl-N-formylglycineamide + Tetrahydrofolic acid
ReactionCard
Thumb+Thumb ↔ Thumb+Thumb+Thumb
N10-Formyl-THF + Glycineamideribotide ↔ Hydrogen ion + Tetrahydrofolic acid + 5'-Phosphoribosyl-N-formylglycineamide
ReactionCard
SMPDB Reactions:
Tetrahydrofolic acid+5'-Phosphoribosyl-N-formylglycinamide+Thumb+Thumb → Thumb+Thumb+Glycineamideribotide+Thumb
Tetrahydrofolic acid + 5'-Phosphoribosyl-N-formylglycinamide + Tetrahydrofolic acid + 5'-Phosphoribosyl-N-formylglycineamide → Water + 5,10-Methenyltetrahydrofolic acid + Glycineamideribotide + Glycineamideribotide
ReactionCard
Tetrahydrofolic acid+5'-Phosphoribosyl-N-formylglycinamide+Thumb+Thumb → 10-Formyltetrahydrofolate+Glycineamideribotide+Thumb+Thumb
Tetrahydrofolic acid + 5'-Phosphoribosyl-N-formylglycinamide + Tetrahydrofolic acid + 5'-Phosphoribosyl-N-formylglycineamide → 10-Formyltetrahydrofolate + Glycineamideribotide + N10-Formyl-THF + Glycineamideribotide
ReactionCard
Thumb+Tetrahydrofolic acid+Thumb → Thumb+Glycineamideribotide+Thumb+Thumb
5'-phosphoribosyl-a-N-formylglycineamidine + Tetrahydrofolic acid + Tetrahydrofolic acid → Water + Glycineamideribotide + 5,10-Methenyltetrahydrofolic acid + Glycineamideribotide
ReactionCard
Thumb+Thumb+Thumb → 5'-Phosphoribosyl-N-formylglycinamide+Adenosine diphosphate+Thumb+Thumb+Thumb+Thumb
N1-(5-phospho-β-D-ribosyl)glycinamide + Adenosine triphosphate + Formic acid → 5'-Phosphoribosyl-N-formylglycinamide + Adenosine diphosphate + Phosphate + Hydrogen ion + 5'-Phosphoribosyl-N-formylglycineamide + ADP
ReactionCard
PseudoCyc/BioCyc Reactions:
Thumb+Thumb ↔ Thumb+Thumb
Acetic acid + Adenosine triphosphate ↔ Acetylphosphate + ADP
ReactionCard
Thumb+Thumb+Thumb → Thumb+Thumb+Thumb+Thumb
Adenosine triphosphate + Formic acid + Glycineamideribotide → ADP + 5'-Phosphoribosyl-N-formylglycineamide + Hydrogen ion + Phosphate
ReactionCard
Thumb+Thumb ↔ Thumb+Thumb+Thumb
N10-Formyl-THF + Glycineamideribotide ↔ 5'-Phosphoribosyl-N-formylglycineamide + Hydrogen ion + Tetrahydrofolic acid
ReactionCard
Thumb+Thumb ↔ Thumb+Thumb
Acetic acid + Adenosine triphosphate ↔ Acetylphosphate + ADP
ReactionCard
Thumb+Thumb ↔ Thumb+Thumb+Thumb
N10-Formyl-THF + Glycineamideribotide ↔ Hydrogen ion + Tetrahydrofolic acid + 5'-Phosphoribosyl-N-formylglycineamide
ReactionCard
Thumb+Thumb+Thumb → Thumb+Thumb+Thumb+Thumb
Glycineamideribotide + Formic acid + Adenosine triphosphate → Hydrogen ion + Phosphate + 5'-Phosphoribosyl-N-formylglycineamide + ADP
ReactionCard
Complex Reactions:
Thumb+Thumb+Thumb → Thumb+Thumb+Thumb
Formic acid + Adenosine triphosphate + 5'-Phospho-ribosylglycinamide → 5'-Phosphoribosyl-N-formylglycineamide + ADP + Pyrophosphate
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB0034315'-Phospho-ribosylglycinamideMetaboCard
PAMDB0061955'-phosphoribosyl-a-N-formylglycineamidineMetaboCard
PAMDB0003325'-Phosphoribosyl-N-formylglycineamideMetaboCard
PAMDB0015855,10-MethenyltetrahydrofolateMetaboCard
PAMDB0061845,10-Methenyltetrahydrofolic acidMetaboCard
PAMDB000012Acetic acidMetaboCard
PAMDB000402AcetylphosphateMetaboCard
PAMDB000148Adenosine triphosphateMetaboCard
PAMDB000345ADPMetaboCard
PAMDB000053Formic acidMetaboCard
PAMDB000422GlycineamideribotideMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB006363N1-(5-phospho-β-D-ribosyl)glycinamideMetaboCard
PAMDB000213N10-Formyl-THFMetaboCard
PAMDB000383PhosphateMetaboCard
PAMDB000633PyrophosphateMetaboCard
PAMDB000424Tetrahydrofolic acidMetaboCard
PAMDB000142WaterMetaboCard
GO Classification:
Function
adenyl nucleotide binding
adenyl ribonucleotide binding
ATP binding
binding
catalytic activity
cation binding
glycine hydroxymethyltransferase activity
hydroxymethyl-, formyl- and related transferase activity
ion binding
magnesium ion binding
metal ion binding
methyltransferase activity
nucleoside binding
purine nucleoside binding
transferase activity
transferase activity, transferring one-carbon groups
Process
cellular nitrogen compound metabolic process
metabolic process
nitrogen compound metabolic process
nucleobase, nucleoside and nucleotide metabolic process
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
nucleoside phosphate metabolic process
nucleotide metabolic process
purine nucleotide biosynthetic process
purine nucleotide metabolic process
purine ribonucleotide biosynthetic process
Gene Properties
Locus tag: PA3751
Strand: -
Entrez Gene ID: 880455
Accession: NP_252440.1
GI: 15598946
Sequence start: 4203324
Sequence End: 4204505
Sequence Length: 1181
Gene Sequence: 
>PA3751
ATGACCCGTATCGGTACCCCCCTGTCGCCGAGCGCGACCCGCGTCCTTCTCTGTGGCTCCGGCGAGCTGGGCAAGGAAGTCGCCATCGAGCTGCAACGCCTGGGTTGCGAAGTGATCGCCGTCGATCGCTATGGCAACGCGCCGGCCATGCAGGTGGCACATCGCAGCCACGTGATCAGCATGCTCGACGGCGCCGCCCTGCGCGCGGTGATCGAGCAGGAGAAGCCGCACTACATCGTGCCGGAGATCGAGGCCATCGCCACCGCGACCCTGGTCGAGCTGGAGGCCGAAGGCTACACCGTGGTGCCCACCGCCCGCGCCGCGCAACTGACCATGAACCGCGAGGGTATCCGCCGGCTGGCTGCCGAGGAGCTCGGCTTGCCGACCTCGCCCTATCACTTCGCCGATACCTTCGAGGACTACCGCCGTGGCGTCGAGCGCGTCGGCTACCCCTGCGTGGTGAAGCCGATCATGAGTTCGTCGGGCAAGGGCCAGAGCGTCCTGAAAGGCCCCGACGACCTGCAGGCGGCCTGGGACTATGCCCAGGAAGGCGGGCGCGCCGGCAAGGGCCGGGTGATCGTCGAGGGCTTCATCGATTTCGACTACGAAATCACCCTGCTCACCGTGCGCCACGTCGACGGCACCACTTTCTGCGCGCCGATCGGTCACCGCCAGGTCAAGGGCGACTACCACGAGTCCTGGCAGCCGCAGGCGATGAGCGCGCAGGCCCTGGCCGAGTCCGAGCGGGTCGCCCGGGCAGTGACCGAGGCCCTCGGCGGACGCGGGCTGTTCGGCGTCGAACTGTTCGTCAAGGGCGACCAGGTGTGGTTCAGCGAGGTGTCGCCGCGTCCGCACGATACCGGCCTGGTGACCCTGATTTCCCAGGATCTTTCCGAGTTCGCGCTGCACGCGCGGGCGATCCTCGGCCTGCCGATCCCGGTGATCCGCCAGCTCGGCCCGTCGGCCTCGGCGGTGATCCTGGTGGAAGGCAAGTCCCGGCAGGTCGCTTTCGCCAACCTCGGCGCCGCGCTGAGCGAGGCGGATACGGCGCTACGCCTGTTCGGCAAGCCGGAAGTGGATGGCCAGCGGCGGATGGGCGTGGCCCTGGCGCGCGACGAGTCGATCGACGCCGCCCGCGCCAAGGCGACCCGGGCCGCCCAGGCGGTTCGCGTCGAACTCTGA
Protein Properties
Protein Residues: 393
Protein Molecular Weight: 42.3 kDa
Protein Theoretical pI: 6.07
Hydropathicity (GRAVY score): -0.048
Charge at pH 7 (predicted): -4.94
Protein Sequence: 
>PA3751
MTRIGTPLSPSATRVLLCGSGELGKEVAIELQRLGCEVIAVDRYGNAPAMQVAHRSHVISMLDGAALRAVIEQEKPHYIVPEIEAIATATLVELEAEGYTVVPTARAAQLTMNREGIRRLAAEELGLPTSPYHFADTFEDYRRGVERVGYPCVVKPIMSSSGKGQSVLKGPDDLQAAWDYAQEGGRAGKGRVIVEGFIDFDYEITLLTVRHVDGTTFCAPIGHRQVKGDYHESWQPQAMSAQALAESERVARAVTEALGGRGLFGVELFVKGDQVWFSEVSPRPHDTGLVTLISQDLSEFALHARAILGLPIPVIRQLGPSASAVILVEGKSRQVAFANLGAALSEADTALRLFGKPEVDGQRRMGVALARDESIDAARAKATRAAQAVRVEL
References
External Links:
Resource Link
Genome ID: PA3751
Entrez Gene ID: 880455
NCBI Protein ID: 15598946
General Reference: PaperBLAST - Find papers about PA3751 and its homologs