Formic acid (PAMDB000053)

General function:

Involved in iron ion binding

Specific function:

Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions

Gene Name:

def

Locus Tag:

PA0019

Molecular weight:

19.4 kDa

Reactions

General function:

Involved in GTP cyclohydrolase II activity

Specific function:

Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate

Gene Name:

ribA

Locus Tag:

PA4047

Molecular weight:

22.1 kDa

Reactions

General function:

Involved in 3,4-dihydroxy-2-butanone-4-phosphate synthase activity

Specific function:

Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate

Gene Name:

ribB

Locus Tag:

PA4054

Molecular weight:

39.4 kDa

Reactions

General function:

Involved in electron carrier activity

Specific function:

Formate dehydrogenase allows Pseudomonas aeruginosa to use formate as major electron donor during anaerobic respiration, when nitrate is used as electron acceptor. The beta chain is an electron transfer unit containing 4 cysteine clusters involved in the formation of iron-sulfur centers. Electrons are transferred from the gamma chain to the molybdenum cofactor of the alpha subunit

Gene Name:

fdnH

Locus Tag:

PA4811

Molecular weight:

33.8 kDa

General function:

Involved in respiratory electron transport chain

Specific function:

Formate dehydrogenase allows Pseudomonas aeruginosa to use formate as major electron donor during anaerobic respiration, when nitrate is used as electron acceptor. Subunit gamma is the cytochrome b556(FDN) component of the formate dehydrogenase

Gene Name:

fdnI

Locus Tag:

PA4810

Molecular weight:

23.9 kDa

General function:

Involved in formate dehydrogenase (NAD+) activity

Specific function:

Formate dehydrogenase allows Pseudomonas aeruginosa to use formate as major electron donor during anaerobic respiration, when nitrate is used as electron acceptor. The alpha subunit forms the active site

Gene Name:

fdnG

Locus Tag:

PA4812

Molecular weight:

104.7 kDa

Reactions

General function:

Involved in carboxylesterase activity

Specific function:

Serine hydrolase involved in the detoxification of formaldehyde. Hydrolyzes S-formylglutathione to glutathione and formate. Shows also esterase activity against alpha-naphthyl acetate, lactoylglutathione, palmitoyl-CoA and several pNP-esters of short chain fatty acids

Gene Name:

yeiG

Locus Tag:

PA3628

Molecular weight:

31.2 kDa

Reactions

General function:

Involved in ATP binding

Specific function:

Catalyzes two reactions:the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR; the second, a side reaction, is the production of acetyl phosphate and ADP from acetate and ATP

Gene Name:

purT

Locus Tag:

PA3751

Molecular weight:

42.3 kDa

Reactions

General function:

Involved in hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

Specific function:

Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (Probable)

Gene Name:

arnD

Locus Tag:

PA3555

Molecular weight:

32.9 kDa

Reactions

General function:

Involved in thiamine biosynthetic process

Specific function:

Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction

Gene Name:

thiC

Locus Tag:

PA4973

Molecular weight:

69.8 kDa

Reactions