Diacylglycerol kinase (PA3603)

Identification
Name: Diacylglycerol kinase
Synonyms:
  • DAGK
  • Diglyceride kinase
  • DGK
Gene Name: dgkA
Enzyme Class:
Biological Properties
General Function: Involved in diacylglycerol kinase activity
Specific Function: Recycling of diacylglycerol produced during the turnover of membrane phospholipid
Cellular Location: Cell inner membrane; Multi-pass membrane protein
KEGG Pathways:
KEGG Reactions:
Thumb+1,2-Diacyl-sn-glycerol+1,2-Diacyl-sn-glycerol ↔ Thumb+Thumb
Adenosine triphosphate + 1,2-Diacyl-sn-glycerol + 1,2-Diacyl-sn-glycerol ↔ ADP + PA(16:0/16:0)
ReactionCard
SMPDB Reactions: Not Available
PseudoCyc/BioCyc Reactions:
Thumb+Thumb → Thumb+Thumb+Thumb
1,2-Diacyl-sn-glycerol (didodecanoyl, n-C12:0) + Adenosine triphosphate → ADP + Hydrogen ion + PA(16:0/16:0)
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Thumb+Thumb → Thumb+Thumb+Thumb
1,2-Diacyl-sn-glycerol (dihexadec-9-enoyl, n-C16:1) + Adenosine triphosphate → ADP + Hydrogen ion + PA(16:0/16:0)
ReactionCard
Thumb+Thumb → Thumb+Thumb+Thumb
1,2-Diacyl-sn-glycerol (dihexadecanoyl, n-C16:0) + Adenosine triphosphate → ADP + Hydrogen ion + PA(16:0/16:0)
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Thumb+Thumb → Thumb+Thumb+Thumb
1,2-Diacyl-sn-glycerol (dioctadec-11-enoyl, n-C18:1) + Adenosine triphosphate → ADP + Hydrogen ion + PA(16:0/16:0)
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Thumb+Thumb → Thumb+Thumb+Thumb
1,2-Diacyl-sn-glycerol (ditetradec-7-enoyl, n-C14:1) + Adenosine triphosphate → ADP + Hydrogen ion + PA(16:0/16:0)
ReactionCard
Thumb+Thumb → Thumb+Thumb+Thumb
1,2-Diacyl-sn-glycerol (ditetradecanoyl, n-C14:0) + Adenosine triphosphate → ADP + Hydrogen ion + PA(16:0/16:0)
ReactionCard
Thumb+1,2-Diacyl-sn-glycerol+1,2-Diacyl-sn-glycerol ↔ Thumb+Thumb
Adenosine triphosphate + 1,2-Diacyl-sn-glycerol + 1,2-Diacyl-sn-glycerol ↔ ADP + PA(16:0/16:0)
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Thumb+1,2-diacylglycerol → Thumb+1,2-diacyl-sn-glycerol 3-phosphate
Adenosine triphosphate + 1,2-diacylglycerol → ADP + 1,2-diacyl-sn-glycerol 3-phosphate
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Thumb
ATP + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycerol 3-phosphate + ADP + H+
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PAMDB120570+PAMDB110525 → PAMDB120317+PAMDB110528+PAMDB001633
2-oleoylglycerol + CTP → 1-oleyl-2-lyso-phosphatidate + CDP + Hydrogen ion
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PAMDB110525+DIACYLGLYCEROL → PAMDB110528+L-PHOSPHATIDATE+PAMDB001633
CTP + DIACYLGLYCEROL → CDP + L-PHOSPHATIDATE + Hydrogen ion
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Complex Reactions:
Thumb+Thumb → Thumb+Thumb+Thumb
1,2-Diacyl-sn-glycerol (didodecanoyl, n-C12:0) + Adenosine triphosphate → ADP + Hydrogen ion + PA(16:0/16:0)
ReactionCard
Thumb+Thumb → Thumb+Thumb+Thumb
1,2-Diacyl-sn-glycerol (dihexadec-9-enoyl, n-C16:1) + Adenosine triphosphate → ADP + Hydrogen ion + PA(16:0/16:0)
ReactionCard
Thumb+Thumb → Thumb+Thumb+Thumb
1,2-Diacyl-sn-glycerol (dihexadecanoyl, n-C16:0) + Adenosine triphosphate → ADP + Hydrogen ion + PA(16:0/16:0)
ReactionCard
Thumb+Thumb → Thumb+Thumb+Thumb
1,2-Diacyl-sn-glycerol (dioctadec-11-enoyl, n-C18:1) + Adenosine triphosphate → ADP + Hydrogen ion + PA(16:0/16:0)
ReactionCard
Thumb+Thumb → Thumb+Thumb+Thumb
1,2-Diacyl-sn-glycerol (ditetradec-7-enoyl, n-C14:1) + Adenosine triphosphate → ADP + Hydrogen ion + PA(16:0/16:0)
ReactionCard
Thumb+Thumb → Thumb+Thumb+Thumb
1,2-Diacyl-sn-glycerol (ditetradecanoyl, n-C14:0) + Adenosine triphosphate → ADP + Hydrogen ion + PA(16:0/16:0)
ReactionCard
Thumb+1,2-diacylglycerol → Thumb+1,2-diacyl-sn-glycerol 3-phosphate
Adenosine triphosphate + 1,2-diacylglycerol → ADP + 1,2-diacyl-sn-glycerol 3-phosphate
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB0015121,2-Diacyl-sn-glycerol (didodecanoyl, n-C12:0)MetaboCard
PAMDB0015131,2-Diacyl-sn-glycerol (dihexadec-9-enoyl, n-C16:1)MetaboCard
PAMDB0015141,2-Diacyl-sn-glycerol (dihexadecanoyl, n-C16:0)MetaboCard
PAMDB0015151,2-Diacyl-sn-glycerol (dioctadec-11-enoyl, n-C18:1)MetaboCard
PAMDB0015171,2-Diacyl-sn-glycerol (ditetradec-7-enoyl, n-C14:1)MetaboCard
PAMDB0015181,2-Diacyl-sn-glycerol (ditetradecanoyl, n-C14:0)MetaboCard
PAMDB0018611,2-Dioctadecanoyl-sn-glycerolMetaboCard
PAMDB000148Adenosine triphosphateMetaboCard
PAMDB000345ADPMetaboCard
PAMDB003631DG(10:0/10:0/0:0)MetaboCard
PAMDB003632DG(10:0/12:0/0:0)MetaboCard
PAMDB003633DG(10:0/14:0/0:0)MetaboCard
PAMDB003634DG(10:0/15:0/0:0)MetaboCard
PAMDB003635DG(10:0/16:0/0:0)MetaboCard
PAMDB003636DG(10:0/16:1(9Z)/0:0)MetaboCard
PAMDB003637DG(10:0/18:0/0:0)MetaboCard
PAMDB003638DG(10:0/18:1(9Z)/0:0)MetaboCard
PAMDB003639DG(10:0/19:1(9Z)/0:0)MetaboCard
PAMDB003640DG(12:0/10:0/0:0)MetaboCard
PAMDB003641DG(12:0/12:0/0:0)MetaboCard
PAMDB003642DG(12:0/14:0/0:0)MetaboCard
PAMDB003643DG(12:0/15:0/0:0)MetaboCard
PAMDB003644DG(12:0/16:0/0:0)MetaboCard
PAMDB003645DG(12:0/16:1(9Z)/0:0)MetaboCard
PAMDB003646DG(12:0/18:0/0:0)MetaboCard
PAMDB003647DG(12:0/18:1(9Z)/0:0)MetaboCard
PAMDB003648DG(12:0/19:1(9Z)/0:0)MetaboCard
PAMDB003649DG(14:0/10:0/0:0)MetaboCard
PAMDB003650DG(14:0/12:0/0:0)MetaboCard
PAMDB003651DG(14:0/14:0/0:0)MetaboCard
PAMDB003652DG(14:0/15:0/0:0)MetaboCard
PAMDB003653DG(14:0/16:0/0:0)MetaboCard
PAMDB003654DG(14:0/16:1(9Z)/0:0)MetaboCard
PAMDB003655DG(14:0/18:0/0:0)MetaboCard
PAMDB003656DG(14:0/18:1(9Z)/0:0)MetaboCard
PAMDB003657DG(14:0/19:1(9Z)/0:0)MetaboCard
PAMDB003658DG(15:0/10:0/0:0)MetaboCard
PAMDB003659DG(15:0/12:0/0:0)MetaboCard
PAMDB003660DG(15:0/14:0/0:0)MetaboCard
PAMDB003661DG(15:0/15:0/0:0)MetaboCard
PAMDB003662DG(15:0/16:0/0:0)MetaboCard
PAMDB003663DG(15:0/16:1(9Z)/0:0)MetaboCard
PAMDB003664DG(15:0/18:0/0:0)MetaboCard
PAMDB003665DG(15:0/18:1(9Z)/0:0)MetaboCard
PAMDB003666DG(15:0/19:1(9Z)/0:0)MetaboCard
PAMDB003667DG(16:0/10:0/0:0)MetaboCard
PAMDB003668DG(16:0/12:0/0:0)MetaboCard
PAMDB003669DG(16:0/14:0/0:0)MetaboCard
PAMDB003670DG(16:0/15:0/0:0)MetaboCard
PAMDB003671DG(16:0/16:0/0:0)MetaboCard
PAMDB003672DG(16:0/16:1(9Z)/0:0)MetaboCard
PAMDB003673DG(16:0/18:0/0:0)MetaboCard
PAMDB003674DG(16:0/18:1(9Z)/0:0)MetaboCard
PAMDB003675DG(16:0/19:1(9Z)/0:0)MetaboCard
PAMDB003676DG(16:1(9Z)/10:0/0:0)MetaboCard
PAMDB003677DG(16:1(9Z)/12:0/0:0)MetaboCard
PAMDB003678DG(16:1(9Z)/14:0/0:0)MetaboCard
PAMDB003679DG(16:1(9Z)/15:0/0:0)MetaboCard
PAMDB003680DG(16:1(9Z)/16:0/0:0)MetaboCard
PAMDB003681DG(16:1(9Z)/16:1(9Z)/0:0)MetaboCard
PAMDB003682DG(16:1(9Z)/18:0/0:0)MetaboCard
PAMDB003683DG(16:1(9Z)/18:1(9Z)/0:0)MetaboCard
PAMDB003684DG(16:1(9Z)/19:1(9Z)/0:0)MetaboCard
PAMDB003685DG(18:0/10:0/0:0)MetaboCard
DG(18:0/12:0/0:0)MetaboCard
PAMDB003687DG(18:0/14:0/0:0)MetaboCard
PAMDB003688DG(18:0/15:0/0:0)MetaboCard
PAMDB003689DG(18:0/16:0/0:0)MetaboCard
PAMDB003690DG(18:0/16:1(9Z)/0:0)MetaboCard
PAMDB003691DG(18:0/18:0/0:0)MetaboCard
PAMDB003692DG(18:0/18:1(9Z)/0:0)MetaboCard
PAMDB003693DG(18:0/19:1(9Z)/0:0)MetaboCard
PAMDB003694DG(18:1(9Z)/10:0/0:0)MetaboCard
PAMDB003695DG(18:1(9Z)/12:0/0:0)MetaboCard
PAMDB003696DG(18:1(9Z)/14:0/0:0)MetaboCard
PAMDB003697DG(18:1(9Z)/15:0/0:0)MetaboCard
PAMDB003698DG(18:1(9Z)/16:0/0:0)MetaboCard
PAMDB003699DG(18:1(9Z)/16:1(9Z)/0:0)MetaboCard
PAMDB003700DG(18:1(9Z)/18:0/0:0)MetaboCard
PAMDB003701DG(18:1(9Z)/18:1(9Z)/0:0)MetaboCard
PAMDB003702DG(18:1(9Z)/19:1(9Z)/0:0)MetaboCard
PAMDB003703DG(19:1(9Z)/10:0/0:0)MetaboCard
PAMDB003704DG(19:1(9Z)/12:0/0:0)MetaboCard
PAMDB003705DG(19:1(9Z)/14:0/0:0)MetaboCard
PAMDB003706DG(19:1(9Z)/15:0/0:0)MetaboCard
PAMDB003707DG(19:1(9Z)/16:0/0:0)MetaboCard
PAMDB003708DG(19:1(9Z)/16:1(9Z)/0:0)MetaboCard
PAMDB003709DG(19:1(9Z)/18:0/0:0)MetaboCard
PAMDB003710DG(19:1(9Z)/18:1(9Z)/0:0)MetaboCard
PAMDB003711DG(19:1(9Z)/19:1(9Z)/0:0)MetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB000169PA(16:0/16:0)MetaboCard
GO Classification:
Component
cell part
membrane
Function
catalytic activity
diacylglycerol kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
Process
metabolic process
organophosphate metabolic process
phospholipid biosynthetic process
phospholipid metabolic process
Gene Properties
Locus tag: PA3603
Strand: -
Entrez Gene ID: 880149
Accession: NP_252293.1
GI: 15598799
Sequence start: 4037945
Sequence End: 4038316
Sequence Length: 371
Gene Sequence: 
>PA3603
GTGTCGCCTTCCCCCTTCAAAGGCCAGACCGGCCTCAAGCGTATCCTCAACGCCACCGGCTATTCCCTCGCAGGTTTCCTCGCCGCCTTCCGCGGTGAAGCCGCCTTCCGCCAACTGGTGCTGCTCAACGTGGTGCTGATCCCGGTGGCCTTCCTCCTCGACGTCAGTCGCGGCGAACGCGCGCTGATGATCGCGGTGTGCCTGCTGGCGCTGATCGTCGAGCTGCTCAACTCGGCGATCGAGGCCACCGTCGACCGCGTCTCGCTGGAACGCCACCCTCTGTCGAAGAATGCCAAGGACATGGGCAGCGCCGCGCAGTTCGTGGCCCTCACCGTGATCACCGTGACCTGGGCGACCATCCTGCTGGGCTGA
Protein Properties
Protein Residues: 123
Protein Molecular Weight: 13.1 kDa
Protein Theoretical pI: 10.03
Hydropathicity (GRAVY score): 0.762
Charge at pH 7 (predicted): 3.19
Protein Sequence: 
>PA3603
MSPSPFKGQTGLKRILNATGYSLAGFLAAFRGEAAFRQLVLLNVVLIPVAFLLDVSRGERALMIAVCLLALIVELLNSAIEATVDRVSLERHPLSKNAKDMGSAAQFVALTVITVTWATILLG
References
External Links:
Resource Link
Genome ID: PA3603
Entrez Gene ID: 880149
NCBI Protein ID: 15598799
General Reference: PaperBLAST - Find papers about PA3603 and its homologs