Phosphoribosylaminoimidazole-succinocarboxamide synthase (PA1013)

Identification
Name: Phosphoribosylaminoimidazole-succinocarboxamide synthase
Synonyms:
  • SAICAR synthetase
Gene Name: purC
Enzyme Class:
Biological Properties
General Function: Involved in ATP binding
Specific Function: ATP + 5-amino-1-(5-phospho-D- ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate
Cellular Location: Not Available
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb+Thumb ↔ Thumb+Thumb+Thumb+Thumb
5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-Aspartic acid + Adenosine triphosphate ↔ SAICAR + ADP + Hydrogen ion + Phosphate
ReactionCard
Thumb+Thumb+Thumb ↔ Thumb+Thumb+Thumb
Adenosine triphosphate + 5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-Aspartic acid ↔ ADP + Phosphate + SAICAR
ReactionCard
Thumb+Thumb+Thumb → Thumb+Thumb+Thumb+Thumb
Adenosine triphosphate + 5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-Aspartic acid → Hydrogen ion + ADP + Phosphate + SAICAR
ReactionCard
SMPDB Reactions:
Thumb+L-Aspartic acid+Thumb+Thumb → SAICAR+Thumb+Adenosine diphosphate+Thumb+Thumb+Thumb
5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-Aspartic acid + Adenosine triphosphate + L-Aspartic acid → SAICAR + Phosphate + Adenosine diphosphate + Hydrogen ion + SAICAR + ADP
ReactionCard
PseudoCyc/BioCyc Reactions:
Thumb+Thumb+Thumb ↔ Thumb+Thumb+Thumb+Thumb
5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-Aspartic acid + Adenosine triphosphate ↔ SAICAR + ADP + Hydrogen ion + Phosphate
ReactionCard
Thumb+Thumb+Thumb → Thumb+Thumb+Thumb+Thumb
Adenosine triphosphate + 5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-Aspartic acid → Hydrogen ion + ADP + Phosphate + SAICAR
ReactionCard
Complex Reactions:
Thumb+Thumb+Thumb → Thumb+Thumb+Thumb
Adenosine triphosphate + 5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-Aspartic acid → ADP + Inorganic phosphate + SAICAR
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB0006635-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylateMetaboCard
PAMDB000148Adenosine triphosphateMetaboCard
PAMDB000345ADPMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB001776Inorganic phosphateMetaboCard
PAMDB000080L-Aspartic acidMetaboCard
PAMDB000383PhosphateMetaboCard
PAMDB000186SAICARMetaboCard
GO Classification:
Function
acid-amino acid ligase activity
adenyl nucleotide binding
adenyl ribonucleotide binding
ATP binding
binding
catalytic activity
ligase activity
ligase activity, forming carbon-nitrogen bonds
nucleoside binding
phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
purine nucleoside binding
Process
cellular nitrogen compound metabolic process
metabolic process
nitrogen compound metabolic process
nucleobase, nucleoside and nucleotide metabolic process
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
nucleoside phosphate metabolic process
nucleotide metabolic process
purine nucleotide biosynthetic process
purine nucleotide metabolic process
Gene Properties
Locus tag: PA1013
Strand: +
Entrez Gene ID: 881642
Accession: NP_249704.1
GI: 15596210
Sequence start: 1096063
Sequence End: 1096773
Sequence Length: 710
Gene Sequence: 
>PA1013
ATGGAAAAACGCGAAGAACTCTACCGCGGCAAAGCCAAGTCGGTTTACCAGACCGACGATGCCGATCGTCTCATCCTGCTGTTCCGCAACGACACCTCCGCCTTCGACGGCAAGCGCATCGAACAGCTCGATCGCAAGGGCGCGGTGAACAACAAGTTCAACGCCTTCATCATGCAGAAGCTGGAAGCTGCCGGCATTCCGACCCAGTTCGACAAGCTGCTGTCGGATACCGAGTGCCTGGTGAAGAAGCTCGACATGATCCCGGTCGAGTGCGTGGTGCGCAATTTCGCCGCCGGCAGCCTGGTGCGTCGCCTCGGCGTGGAAGAGGGCATCGCCCTGACTCCTCCCACCTTCGAGTTGTTCCTGAAGAACGACGCCCTGGGCGATCCGTTCATCAACGAATCCCACGTCCAGGCCTTCGGCTGGGCCACTCCCGAGCAGCTGGCGCAGATGAAGACCTATTCCTTCAAGGTCAATGAAGTGCTGAACAAGCTGTTCGACGATGCCGGTCTGCTGCTGGTGGACTTCAAGCTGGAGTTCGGCCTGTTCCATGGCCAGATCGTCCTCGGCGACGAGTTCAGCCCGGACGGCTGCCGTCTGTGGGACAAGGAAACCCGCAAGAAGATGGACAAGGACCGCTTCCGCCAGGGCCTCGGCGATGTGATCGAAGCCTACGAAGAGGTAGCCAAGCGCCTGGGCGTGCCGCTTTAA
Protein Properties
Protein Residues: 236
Protein Molecular Weight: 26.8 kDa
Protein Theoretical pI: 5.08
Hydropathicity (GRAVY score): -0.306
Charge at pH 7 (predicted): -4.6
Protein Sequence: 
>PA1013
MEKREELYRGKAKSVYQTDDADRLILLFRNDTSAFDGKRIEQLDRKGAVNNKFNAFIMQKLEAAGIPTQFDKLLSDTECLVKKLDMIPVECVVRNFAAGSLVRRLGVEEGIALTPPTFELFLKNDALGDPFINESHVQAFGWATPEQLAQMKTYSFKVNEVLNKLFDDAGLLLVDFKLEFGLFHGQIVLGDEFSPDGCRLWDKETRKKMDKDRFRQGLGDVIEAYEEVAKRLGVPL
References
External Links:
Resource Link
Genome ID: PA1013
Entrez Gene ID: 881642
NCBI Protein ID: 15596210
General Reference: PaperBLAST - Find papers about PA1013 and its homologs