Homoserine kinase (PA5495)

Identification
Name: Homoserine kinase
Synonyms:
  • HK
  • HSK
Gene Name: thrB
Enzyme Class:
Biological Properties
General Function: Involved in ATP binding
Specific Function: Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate. Is also able to phosphorylate the hydroxy group on gamma-carbon of L-homoserine analogs when the functional group at the alpha-position is a carboxyl, an ester, or even a hydroxymethyl group. Neither L- threonine nor L-serine are substrates of the enzyme
Cellular Location: Cytoplasm (Probable)
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb ↔ Thumb+Thumb+Thumb
Adenosine triphosphate + L-Homoserine ↔ ADP + Hydrogen ion + O-Phosphohomoserine
ReactionCard
Thumb+Thumb ↔ Thumb+Thumb
Adenosine triphosphate + L-Homoserine ↔ ADP + O-Phosphohomoserine
ReactionCard
SMPDB Reactions:
L-Homoserine+Thumb+Thumb → Adenosine diphosphate+Thumb+Thumb+Thumb
L-Homoserine + Adenosine triphosphate + L-Homoserine → Adenosine diphosphate + Hydrogen ion + O-Phosphohomoserine + ADP
ReactionCard
PseudoCyc/BioCyc Reactions:
Thumb+Thumb ↔ Thumb+Thumb+Thumb
Adenosine triphosphate + L-Homoserine ↔ ADP + Hydrogen ion + O-Phosphohomoserine
ReactionCard
Thumb+Thumb ↔ Thumb+Thumb
Adenosine triphosphate + L-Homoserine ↔ ADP + O-Phosphohomoserine
ReactionCard
Complex Reactions:
Thumb+Thumb → Thumb+Thumb
Adenosine triphosphate + L-Homoserine → ADP + O-Phosphohomoserine
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB000148Adenosine triphosphateMetaboCard
PAMDB000345ADPMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB000449L-HomoserineMetaboCard
PAMDB000505O-PhosphohomoserineMetaboCard
GO Classification:
Function
adenyl nucleotide binding
adenyl ribonucleotide binding
ATP binding
binding
catalytic activity
homoserine kinase activity
kinase activity
nucleoside binding
phosphotransferase activity, alcohol group as acceptor
purine nucleoside binding
transferase activity
transferase activity, transferring phosphorus-containing groups
Process
aspartate family amino acid metabolic process
cellular amino acid and derivative metabolic process
cellular amino acid metabolic process
cellular metabolic process
metabolic process
phosphate metabolic process
phosphorus metabolic process
phosphorylation
threonine metabolic process
Gene Properties
Locus tag: PA5495
Strand: +
Entrez Gene ID: 877825
Accession: NP_254182.1
GI: 15600688
Sequence start: 6186927
Sequence End: 6187877
Sequence Length: 950
Gene Sequence: 
>PA5495
ATGTCGGTGTTCACCCCACTCGAACGCTCGACCCTGGAAGCCTTCCTCGCCCCCTACGACCTGGGCCGCCTGCGGGATTTCCGTGGCATCGCCGAAGGCTCCGAGAACAGCAACTTCTTCGTCAGCCTGGAACACGGCGAGTTCGTCCTGACCCTGGTCGAGCGCGGCCCGGTGCAGGACCTGCCGTTCTTCATCGAACTGCTCGACGTGCTCCACGAGGACGGCCTGCCGGTGCCCTACGCCCTGCGCACCCGCGACGGCGAGGCCCTGCGCCGTCTCGAAGGCAAGCCGGCGCTGCTGCAACCGCGCCTGGCCGGCCGCCACGAGCGGCAGCCGAACGCCCACCACTGCCAGGAAGTGGGCGATCTGCTCGGCCACCTTCACGCCGCCACCCGCGGGCGCATCCTCGAACGCCCGAGCGACCGTGGCCTGCCCTGGATGCTGGAACAAGGTGCCAACCTCGCCCCGCGACTACCGGAACAGGCCCGCGCCCTGCTCGCCCCGGCCCTGGCGGAGATCGCCGCGCTGGATGCCGAGCGTCCAGCGCTGCCGCGCGCCAACCTGCATGCCGACCTGTTCCGCGACAACGTGCTGTTCGACGGCCCGCACCTGGCCGGCCTGATCGACTTCTACAACGCCTGCTCCGGCTGGATGCTCTACGACCTGGCGATCACCCTGAACGACTGGTGCTCCAATACCGACGGCAGCCTGGACCCGGCCCGCGCCCGCGCCCTGCTCGCCGCCTACGCCAACCGCCGGCCGTTCACCGCGCTGGAAGCCGAGCACTGGCCGAGCATGCTGCGGGTCGCCTGCGTGCGCTTCTGGCTGTCGCGACTGATCGCCGCCGAGGCGTTCGCCGGACAGGACGTGCTGATCCATGATCCGGCGGAGTTCGAGATACGCCTGGCGCAACGGCAGAACGTGGAGATTCATTTGCCGTTTGCGTTGTAG
Protein Properties
Protein Residues: 316
Protein Molecular Weight: 35.4 kDa
Protein Theoretical pI: 5.56
Hydropathicity (GRAVY score): -0.109
Charge at pH 7 (predicted): -9.22
Protein Sequence: 
>PA5495
MSVFTPLERSTLEAFLAPYDLGRLRDFRGIAEGSENSNFFVSLEHGEFVLTLVERGPVQDLPFFIELLDVLHEDGLPVPYALRTRDGEALRRLEGKPALLQPRLAGRHERQPNAHHCQEVGDLLGHLHAATRGRILERPSDRGLPWMLEQGANLAPRLPEQARALLAPALAEIAALDAERPALPRANLHADLFRDNVLFDGPHLAGLIDFYNACSGWMLYDLAITLNDWCSNTDGSLDPARARALLAAYANRRPFTALEAEHWPSMLRVACVRFWLSRLIAAEAFAGQDVLIHDPAEFEIRLAQRQNVEIHLPFAL
References
External Links:
Resource Link
Genome ID: PA5495
Entrez Gene ID: 877825
NCBI Protein ID: 15600688
General Reference: PaperBLAST - Find papers about PA5495 and its homologs