D-alanine--D-alanine ligase A (PA4201)

Identification
Name: D-alanine--D-alanine ligase A
Synonyms:
  • D-Ala-D-Ala ligase A
  • D-alanylalanine synthetase A
Gene Name: ddlA
Enzyme Class:
Biological Properties
General Function: Involved in ATP binding
Specific Function: Cell wall formation
Cellular Location: Cytoplasm
KEGG Pathways:
KEGG Reactions:
2 Thumb+Thumb ↔ Thumb+Thumb+Thumb+Thumb
2 D-Alanine + Adenosine triphosphate ↔ ADP + D-Alanyl-D-alanine + Hydrogen ion + Phosphate
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Thumb+2 Thumb ↔ Thumb+Thumb+Thumb
Adenosine triphosphate + 2 D-Alanine ↔ ADP + Phosphate + D-Alanyl-D-alanine
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SMPDB Reactions:
2 Thumb+Thumb → Thumb+Adenosine diphosphate+Thumb+Thumb
2 D-Alanine + Adenosine triphosphate → D-Alanyl-D-alanine + Adenosine diphosphate + Phosphate + ADP
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PseudoCyc/BioCyc Reactions:
2 Thumb+Thumb ↔ Thumb+Thumb+Thumb+Thumb
2 D-Alanine + Adenosine triphosphate ↔ ADP + D-Alanyl-D-alanine + Hydrogen ion + Phosphate
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Thumb+Thumb → Thumb+Thumb+Thumb+Thumb
D-Alanine + Adenosine triphosphate → Hydrogen ion + D-Alanyl-D-alanine + Phosphate + ADP
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Complex Reactions:
Thumb+2 Thumb → Thumb+Thumb+Thumb
Adenosine triphosphate + 2 D-Alanine → ADP + Inorganic phosphate + D-Alanyl-D-alanine
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Thumb+2 Thumb → Thumb+Thumb+Thumb
Adenosine triphosphate + 2 D-Alanine → ADP + Inorganic phosphate + D-Alanyl-D-alanine
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Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB000148Adenosine triphosphateMetaboCard
PAMDB000345ADPMetaboCard
PAMDB000333D-AlanineMetaboCard
PAMDB000504D-Alanyl-D-alanineMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB001776Inorganic phosphateMetaboCard
PAMDB000383PhosphateMetaboCard
GO Classification:
Component
cell part
cell wall
cytoplasm
external encapsulating structure
intracellular part
Function
acid-amino acid ligase activity
adenyl nucleotide binding
adenyl ribonucleotide binding
ATP binding
binding
catalytic activity
D-alanine-D-alanine ligase activity
ligase activity
ligase activity, forming carbon-nitrogen bonds
nucleoside binding
purine nucleoside binding
Process
aminoglycan metabolic process
carbohydrate metabolic process
glycosaminoglycan metabolic process
metabolic process
peptidoglycan biosynthetic process
peptidoglycan metabolic process
polysaccharide metabolic process
primary metabolic process
Gene Properties
Locus tag: PA4201
Strand: -
Entrez Gene ID: 879033
Accession: NP_252890.1
GI: 15599396
Sequence start: 4700906
Sequence End: 4701946
Sequence Length: 1040
Gene Sequence: 
>PA4201
ATGGGACAGGACAAGTTGAAGGTCGCCGTTCTCTTCGGCGGCAGCAGTGAGGAACGGGACGTCTCCATCGCCAGCGGCGCGCAGGTGATCCAGGCTTTGCGCAGCGCCGGCCACCAGGTGCTGGCGGTGGATACCGCCAGCGGCCTGCTCGGCGCGGAGGAAGAGCGCCGCCTGCTGGCGAGCAAGGTCAAGGAGGTCCCGCCGGACTCCGACTCGCTGGCGATCATCCGCAGCGGCAAGCAGAGCCTGCTGAGCGCCGGCGAACTGGCTGGGGTCGACGTGTTCTTCCTCGCCCTGCACGGCGGCACCGGCGAGGACGGCACCCTGCAGGCGCTGCTGGATGCCGGTGGTTTCGCCTATACCGGCAGCGGCCACCTGGCCAGCGCCATGGCGATGGACAAGGACGTGGCCAAGCGCCTGTTCCTCGCCGCCGGGGTGGAGACCGCCAGTTGGCTGATGGCGCCGGCCTCGGAAGAGGAGGTGCGCGAGCAACTGGGCTTCCCCCTGGTGGTCAAGCCGAACAGCCAGGGCTCCACCGTGGGGCTGTCCATCGTGCATTCCCAGGCCGAATTGCAGCCGGCCATCGAGCTGGCCGGGCGCTATGGCGACGAGGTGATGCTGGAGCGCTTCGTCGCCGGCCGCGAGGTCACCGTCGGGGTGCTCGACGACCAGGCGCTGCCGGTGGGCGAGATTCTCCTCGGCGGCCAGGAGGTCTTCGACTACGAGCACAAGTACCAGGCCGGCGCGGTGCGCGAGGTGTTTCCCGCCGACCTGCCGCCGGCGATCGCCGCCGAGGCCCAGCGTCTGGCGCTGAAGGTACACCGGGCGCTGAAGCTGAGCGGCTACAGCCGCACCGACTTCCGCCTCGACGAACAGGGCCGGCTCTGGTGCCTGGAGGTCAATACCCTGCCGGGCATGACCGCCACCAGCCTGCTGCCGCAGGCCGCGGCGGCGGCCGGGATCGGTTTCGCCGAACTCTGCGAGCGGATCTGCCGGCTCGGCATCGAGCGCTGCAAGGGCGCGCGCAAGGCGCGTTCCTGA
Protein Properties
Protein Residues: 346
Protein Molecular Weight: 36.5 kDa
Protein Theoretical pI: 4.92
Hydropathicity (GRAVY score): 0.054
Charge at pH 7 (predicted): -9.66
Protein Sequence: 
>PA4201
MGQDKLKVAVLFGGSSEERDVSIASGAQVIQALRSAGHQVLAVDTASGLLGAEEERRLLASKVKEVPPDSDSLAIIRSGKQSLLSAGELAGVDVFFLALHGGTGEDGTLQALLDAGGFAYTGSGHLASAMAMDKDVAKRLFLAAGVETASWLMAPASEEEVREQLGFPLVVKPNSQGSTVGLSIVHSQAELQPAIELAGRYGDEVMLERFVAGREVTVGVLDDQALPVGEILLGGQEVFDYEHKYQAGAVREVFPADLPPAIAAEAQRLALKVHRALKLSGYSRTDFRLDEQGRLWCLEVNTLPGMTATSLLPQAAAAAGIGFAELCERICRLGIERCKGARKARS
References
External Links:
Resource Link
Genome ID: PA4201
Entrez Gene ID: 879033
NCBI Protein ID: 15599396
General Reference: PaperBLAST - Find papers about PA4201 and its homologs