Identification
Name: L-seryl-tRNA(Sec) selenium transferase
Synonyms:
  • Selenocysteine synthase
  • Sec synthase
  • Selenocysteinyl-tRNA(Sec) synthase
Gene Name: selA
Enzyme Class:
Biological Properties
General Function: Involved in catalytic activity
Specific Function: Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis. Requires selenophosphate as the selenium-donor molecule
Cellular Location: Cytoplasm
KEGG Pathways:
KEGG Reactions:
L-Seryl-tRNA(Sec)+Thumb+L-Seryl-tRNA(Sec)L-Selenocysteinyl-tRNA(Sec)+Thumb+L-Selenocysteinyl-tRNA(Sec)
L-Seryl-tRNA(Sec) + Phosphoroselenoic acid + L-Seryl-tRNA(Sec) ↔ L-Selenocysteinyl-tRNA(Sec) + Phosphate + L-Selenocysteinyl-tRNA(Sec)
ReactionCard
SMPDB Reactions: Not Available
PseudoCyc/BioCyc Reactions:
ThumbThumb+Thumb+L-Selenocysteinyl-tRNA(Sec)
Phosphoroselenoic acidHydrogen ion + Phosphate + L-Selenocysteinyl-tRNA(Sec)
ReactionCard
L-Seryl-tRNA(Sec)+Thumb+L-Seryl-tRNA(Sec)L-Selenocysteinyl-tRNA(Sec)+Thumb+L-Selenocysteinyl-tRNA(Sec)
L-Seryl-tRNA(Sec) + Phosphoroselenoic acid + L-Seryl-tRNA(Sec) ↔ L-Selenocysteinyl-tRNA(Sec) + Phosphate + L-Selenocysteinyl-tRNA(Sec)
ReactionCard
L-seryl-tRNA(Sec)+ThumbL-selenocysteinyl-tRNA(Sec)+Thumb
L-seryl-tRNA(Sec) + Phosphoroselenoic acid → L-selenocysteinyl-tRNA(Sec) + Inorganic phosphate
ReactionCard
Thumb
selenophosphate + an L-seryl-[tRNAsec] = an L-selenocysteinyl-[tRNAsec] + phosphate
ReactionCard
Complex Reactions:
ThumbThumb+Thumb+L-Selenocysteinyl-tRNA(Sec)
Phosphoroselenoic acidHydrogen ion + Phosphate + L-Selenocysteinyl-tRNA(Sec)
ReactionCard
L-seryl-tRNA(Sec)+ThumbL-selenocysteinyl-tRNA(Sec)+Thumb
L-seryl-tRNA(Sec) + Phosphoroselenoic acid → L-selenocysteinyl-tRNA(Sec) + Inorganic phosphate
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB001633Hydrogen ionMetaboCard
PAMDB001776Inorganic phosphateMetaboCard
PAMDB000383PhosphateMetaboCard
PAMDB000525Phosphoroselenoic acidMetaboCard
GO Classification:
Component
cell part
cytoplasm
intracellular part
Function
catalytic activity
L-seryl-tRNASec selenium transferase activity
selenotransferase activity
transferase activity
transferase activity, transferring selenium-containing groups
Process
biosynthetic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
metabolic process
selenocysteine incorporation
translational elongation
translational readthrough
Gene Properties
Locus tag: PA4808
Strand: -
Entrez Gene ID: 880198
Accession: NP_253496.1
GI: 15600002
Sequence start: 5394445
Sequence End: 5395851
Sequence Length: 1406
Gene Sequence:
>PA4808
ATGAGTTCCGTTCGCTTGCCTTCGGTCGACCGCCTGCTGCGCAGCGCGGCGGCCGCTCCCCTGCACCAGCGCTATGGCCGCGAGGCGTTGCTGGCGACCCTCCGCGACCTGCTCGACGAACTGCGCGAGCCGGCCCGACACGGTGCCCTCGCCGAGATCGAACTGAGCGAGGCGGTGCTCGCCGGGCGCGCCGGCGAACGCCTCGCCGCGCAGCATGCCAGCCGCGTGCGGCGGGTGTTCAACCTGACCGGCACGGTGTTGCATACCAACCTCGGCCGCGCCCTGCTGCCGGACGAAGCCATCGAGGCGATCACCCTGGCCGCGCGCTACCCGCTGAACCTGGAGTTCGACCTGGCCAGCGGCAAGCGCGGCGACCGCGACGACCTGATCGCCGGGCTGATCCGCGAACTCACCGGCGCCGAGGCGGTCACCGTGGTCAACAACAACGCGGCGGCGGTGCTGCTGGCGCTGAACAGCCTGGGGGCGCGCAAGGAAGGGATCATCTCGCGCGGCGAGCTGATCGAGATCGGCGGCGCCTTCCGCATTCCCGACATCATGGCCCGCGCCGGCGTGCGCTTGCACGAGGTGGGCACCACCAACCGCACCCACGCCAAGGACTACGAAGCCGCCATCGGCCCGCGCAGCGGCCTGCTGATGCGCGTGCACACCAGCAACTACAGCGTCCAGGGCTTCACCGCCAGCGTGCCCACCGCGCAACTGGCGGCCATCGCCCATGGCCACGGCCTGCCGCTGCTGGAAGACCTCGGCAGCGGCACCCTGGTGGACCTGACCCGCTGGGGCTTGCCCAAGGAACCGACGGTGCAGGAAGCCCTGGCCGACGGCGCCGACATCGTTACCTTCAGCGGCGACAAATTGCTCGGCGGGCCCCAGGCCGGGCTGATCCTCGGCAACCGCGAACTGATCGGGCGGATCAAGAAGAACCCGCTCAAGCGCGCTCTGCGCGTCGACAAGCTGACCCTCGCCGCCCTCGAGGCGGTGCTCGGCCTGTACCGCGATCCGGACCGCCTCGCCGAACGCCTGACCACCCTGCGCCTGCTCAGCCGCCCGGCGGCGGAGATCCGCGCCCAGGCCGAGCGTCTGGCGCCGGCGCTGGGCGAGGCGCTCGGCGAGGGCTGGGAGGTCGCTGTGGTCGACGCCCTGGGCATGATCGGCAGCGGCGCGCAGCCGGTGGCGCGGCTGGCCAGCGCCGCGCTGTGCCTGCGTCCGCGGCAGCCCAGGCGCCTGCGCGGACGCGCCCTGCGCAACCTCGAGGAAGCCCTGCGCGGGCTGCCGCTGCCGGTGATCGGTCGGCTCGACGACGACGCCCTCTGGCTCGATCTGCGCCAGCTCGACGACGAGCCGGCGTTCCTCGCCCAGTTGCCGCGACTGCGGAGCGAGCTGTCGTGA
Protein Properties
Protein Residues: 468
Protein Molecular Weight: 50.3 kDa
Protein Theoretical pI: 9.41
Hydropathicity (GRAVY score): -0.022
Charge at pH 7 (predicted): 5.16
Protein Sequence:
>PA4808
MSSVRLPSVDRLLRSAAAAPLHQRYGREALLATLRDLLDELREPARHGALAEIELSEAVLAGRAGERLAAQHASRVRRVFNLTGTVLHTNLGRALLPDEAIEAITLAARYPLNLEFDLASGKRGDRDDLIAGLIRELTGAEAVTVVNNNAAAVLLALNSLGARKEGIISRGELIEIGGAFRIPDIMARAGVRLHEVGTTNRTHAKDYEAAIGPRSGLLMRVHTSNYSVQGFTASVPTAQLAAIAHGHGLPLLEDLGSGTLVDLTRWGLPKEPTVQEALADGADIVTFSGDKLLGGPQAGLILGNRELIGRIKKNPLKRALRVDKLTLAALEAVLGLYRDPDRLAERLTTLRLLSRPAAEIRAQAERLAPALGEALGEGWEVAVVDALGMIGSGAQPVARLASAALCLRPRQPRRLRGRALRNLEEALRGLPLPVIGRLDDDALWLDLRQLDDEPAFLAQLPRLRSELS
References
External Links:
Resource Link
Genome ID: PA4808
Entrez Gene ID: 880198
NCBI Protein ID: 15600002
General Reference: PaperBLAST - Find papers about PA4808 and its homologs