Histidine biosynthesis bifunctional protein hisB (PA5143)

Identification
Name: Histidine biosynthesis bifunctional protein hisB
Synonyms:
  • Histidinol-phosphatase
  • Imidazoleglycerol-phosphate dehydratase
  • IGPD
Gene Name: hisB
Enzyme Class:
Biological Properties
General Function: Involved in catalytic activity
Specific Function: D-erythro-1-(imidazol-4-yl)glycerol 3- phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H(2)O
Cellular Location: Cytoplasm
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb ↔ Thumb+Thumb
Water + Histidinol phosphate ↔ L-Histidinol + Phosphate
ReactionCard
Thumb ↔ Thumb+Thumb
D-Erythro-imidazole-glycerol-phosphate ↔ Water + Imidazole acetol-phosphate
ReactionCard
Thumb+Thumb ↔ Thumb+Thumb
Histidinol phosphate + Water ↔ L-Histidinol + Phosphate
ReactionCard
Thumb ↔ Thumb+Thumb
D-Erythro-imidazole-glycerol-phosphate ↔ Imidazole acetol-phosphate + Water
ReactionCard
SMPDB Reactions:
Thumb → Thumb+Thumb
D-Erythro-imidazole-glycerol-phosphate → Water + Imidazole acetol-phosphate
ReactionCard
Thumb+Thumb → Thumb+Thumb
L-histidinol-phosphate + Water → Phosphate + L-Histidinol
ReactionCard
PseudoCyc/BioCyc Reactions:
Thumb+Thumb ↔ Thumb+Thumb
Water + Histidinol phosphate ↔ L-Histidinol + Phosphate
ReactionCard
Thumb ↔ Thumb+Thumb
D-Erythro-imidazole-glycerol-phosphate ↔ Water + Imidazole acetol-phosphate
ReactionCard
Complex Reactions:
Thumb → Thumb+Thumb
D-Erythro-imidazole-glycerol-phosphate → Imidazole acetol-phosphate + Water
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Thumb+Thumb → Thumb+Thumb
Histidinol phosphate + Water → L-Histidinol + Inorganic phosphate
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Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB000829D-Erythro-imidazole-glycerol-phosphateMetaboCard
PAMDB000487Histidinol phosphateMetaboCard
PAMDB000831Imidazole acetol-phosphateMetaboCard
PAMDB001776Inorganic phosphateMetaboCard
PAMDB000502L-HistidinolMetaboCard
PAMDB006314L-histidinol-phosphateMetaboCard
PAMDB000383PhosphateMetaboCard
PAMDB000142WaterMetaboCard
GO Classification:
Component
cell part
cytoplasm
intracellular part
Function
carbon-oxygen lyase activity
catalytic activity
histidinol-phosphatase activity
hydro-lyase activity
hydrolase activity
hydrolase activity, acting on ester bonds
imidazoleglycerol-phosphate dehydratase activity
lyase activity
phosphatase activity
phosphoric ester hydrolase activity
Process
cellular amino acid and derivative metabolic process
cellular amino acid metabolic process
cellular metabolic process
histidine biosynthetic process
histidine family amino acid metabolic process
histidine metabolic process
metabolic process
Gene Properties
Locus tag: PA5143
Strand: -
Entrez Gene ID: 878789
Accession: NP_253830.1
GI: 15600336
Sequence start: 5791083
Sequence End: 5791676
Sequence Length: 593
Gene Sequence: 
>PA5143
ATGGCCGAACGCAAGGCATCCGTCGCGCGCGACACCCTGGAGACCCAGATCAAGGTCTCCATCGACCTGGATGGGACCGGCAAGGCCCGGTTCGATACCGGGGTTCCCTTCCTTGACCACATGATGGACCAGATCGCCCGCCACGGCCTGATCGACCTGGACATCGAGTGCAAGGGCGACCTGCATATCGACGATCACCACACCGTCGAGGACATCGGCATCACCCTCGGCCAGGCCTTCGCCAAGGCCATCGGCGACAAGAAGGGCATCCGCCGCTACGGCCACGCCTACGTGCCCCTCGACGAGGCGCTGTCGCGGGTGGTCATCGACTTCTCCGGGCGGCCCGGCCTGCAGATGCACGTTCCCTTTACCCGTGCCAGCGTCGGCGGCTTCGACGTCGACCTGTTCATGGAATTCTTCCAGGGCTTCGTCAACCACGCCCAGGTGACCCTGCACATCGACAACCTGCGCGGGCACAACACCCACCACCAGATCGAGACCGTGTTCAAGGCCTTCGGCCGCGCGCTGCGCATGGCCATCGAGCTGGACGAGCGGATGGCCGGGCAGATGCCGTCGACCAAAGGGTGCCTGTGA
Protein Properties
Protein Residues: 197
Protein Molecular Weight: 21.9 kDa
Protein Theoretical pI: 6.51
Hydropathicity (GRAVY score): -0.194
Charge at pH 7 (predicted): -3.18
Protein Sequence: 
>PA5143
MAERKASVARDTLETQIKVSIDLDGTGKARFDTGVPFLDHMMDQIARHGLIDLDIECKGDLHIDDHHTVEDIGITLGQAFAKAIGDKKGIRRYGHAYVPLDEALSRVVIDFSGRPGLQMHVPFTRASVGGFDVDLFMEFFQGFVNHAQVTLHIDNLRGHNTHHQIETVFKAFGRALRMAIELDERMAGQMPSTKGCL
References
External Links:
Resource Link
Genome ID: PA5143
Entrez Gene ID: 878789
NCBI Protein ID: 15600336
General Reference: PaperBLAST - Find papers about PA5143 and its homologs