Alpha-ribazole phosphatase (PA1276)

Identification
Name: Alpha-ribazole phosphatase
Synonyms:
  • Alpha-ribazole-5'-phosphate phosphatase
Gene Name: cobC
Enzyme Class:
Biological Properties
General Function: Involved in catalytic activity
Specific Function: Converts N1-(5-phospho-alpha-D-ribosyl)-5,6- dimethylbenzimidazole into N1-alpha-D-ribosyl-5,6- dimethylbenzimidazole; involved in the assembly of the nucleotide loop of cobalamin
Cellular Location: Cytoplasmic
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb → Thumb+Thumb
N1-(5-Phospho-a-D-ribosyl)-5,6-dimethylbenzimidazole + Water → Phosphate + N1-(alpha-D-ribosyl)-5,6-dimethyl-benzimidazole
ReactionCard
Thumb+Thumb ↔ Thumb+Thumb
N1-(5-Phospho-a-D-ribosyl)-5,6-dimethylbenzimidazole + Water ↔ N1-(alpha-D-ribosyl)-5,6-dimethyl-benzimidazole + Phosphate
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SMPDB Reactions:
Thumb+Thumb → Thumb+coenzyme B12
Adenosylcobalamin 5'-phosphate + Water → Phosphate + coenzyme B12
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PseudoCyc/BioCyc Reactions:
Thumb+Thumb → Thumb+Thumb
N1-(5-Phospho-a-D-ribosyl)-5,6-dimethylbenzimidazole + Water → Phosphate + N1-(alpha-D-ribosyl)-5,6-dimethyl-benzimidazole
ReactionCard
Thumb+Thumb → Thumb+Thumb
N1-(5-Phospho-a-D-ribosyl)-5,6-dimethylbenzimidazole + Water → N1-(alpha-D-ribosyl)-5,6-dimethyl-benzimidazole + Phosphate
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adenosylcobalamin 5'-phosphate+Thumb → Thumb+Thumb
adenosylcobalamin 5'-phosphate + Water → Adenosylcobalamin + Phosphate
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Complex Reactions:
Thumb+Thumb → Thumb+Thumb
Adenosylcobalamin + Water → Adenosylcobalamin + Inorganic phosphate
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Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB000439AdenosylcobalaminMetaboCard
PAMDB003485Adenosylcobalamin 5'-phosphateMetaboCard
PAMDB001776Inorganic phosphateMetaboCard
PAMDB000527N1-(5-Phospho-a-D-ribosyl)-5,6-dimethylbenzimidazoleMetaboCard
PAMDB000805N1-(alpha-D-ribosyl)-5,6-dimethyl-benzimidazoleMetaboCard
PAMDB000383PhosphateMetaboCard
PAMDB000142WaterMetaboCard
GO Classification:
Function
alpha-ribazole phosphatase activity
catalytic activity
hydrolase activity
hydrolase activity, acting on ester bonds
phosphatase activity
phosphoric ester hydrolase activity
Process
cobalamin biosynthetic process
metabolic process
nitrogen compound metabolic process
porphyrin biosynthetic process
porphyrin metabolic process
tetrapyrrole metabolic process
Gene Properties
Locus tag: PA1276
Strand: +
Entrez Gene ID: 881414
Accession: NP_249967.1
GI: 15596473
Sequence start: 1387254
Sequence End: 1388249
Sequence Length: 995
Gene Sequence: 
>PA1276
ATGCTTGAACACGGAGGACGGTTGCGCGAGGCGGCGCGCCGTTACGACATTCCGCTGGCGGACTGGCTGGACCTGTCCACCGGCATCGCGCCCTGGCCGTTTTCGCTGCCGGCGATCCCCGAGCAGGCCTGGACCCGCCTGCCGGAGAGCGACGACGGCCTGGAAGCCGCCGCCTGCCTCTACTACGGCGCCGAACGGGTATTGCCGCTGGCTGGCAGCCAGGCGGCGATCCAGGCCCTGCCGAGGATGCGGCGGGGCGGGCGGGTCGGCGTCCTGTCGCCGTGCTACGCCGAGCACGCCCACGCCTGGCGCCAGGCCGGGCACCTGGTGCGGGAGATCGGCGAGGCCGAGGTCGAGCCCTATCTCGACAGCCTCGACGTGCTGCTGGTGGTCAACCCGAACAACCCCACCGGGCGGGTCTTCGAGCCCGCCGAGCTACTGGCCTGGCATGCCCGCCTGCAACGTCGCGGCGGCTGGCTGCTGGTCGACGAGGCGTTCATGGACTGCACCCCGCAGTCGAGCCTGGCGGCCTGCAGCAACCGGCCCGGATTGATCGTGCTGCGCTCGTTCGGCAAGTTCTTCGGCCTGGCCGGCGCGCGGCTCGGCTTCGCCCTCGGCGAACGGCCGCTGTTGCAGGCGCTGGCCGAGCAGCTCGGTCCGTGGACGGTCAATGGCCCGGTGCGCCATGTGGCCCAGAGTGCCTTGCGCGACCGCCAGCAACAGCGCCAGCAGCGCGAGCGCCTGCTGGCCGCCAGCCAGCGCCTGGAGGAACTGCTGCGCCGCCACGGCTGGCCGCCGGCGGGCGGCAGCGCGCTGTTCCAGCGCCTGGTCGATCCACGCTGCGCGGCGTTGCACGACTACCTGGCGCGGCGCGGCATCCTCACCCGCCAATTCGAGCAGCCGGCCAGCCTGCGCCTCGGCCTGCCCGCCGACGAGGCCGCCTGGGCCCGGCTGGATGCCGCGCTGCTCGGCTTCAAGGAGCCTGCTCATGAGTGA
Protein Properties
Protein Residues: 331
Protein Molecular Weight: 36.7 kDa
Protein Theoretical pI: 7.95
Hydropathicity (GRAVY score): -0.224
Charge at pH 7 (predicted): 3.02
Protein Sequence: 
>PA1276
MLEHGGRLREAARRYDIPLADWLDLSTGIAPWPFSLPAIPEQAWTRLPESDDGLEAAACLYYGAERVLPLAGSQAAIQALPRMRRGGRVGVLSPCYAEHAHAWRQAGHLVREIGEAEVEPYLDSLDVLLVVNPNNPTGRVFEPAELLAWHARLQRRGGWLLVDEAFMDCTPQSSLAACSNRPGLIVLRSFGKFFGLAGARLGFALGERPLLQALAEQLGPWTVNGPVRHVAQSALRDRQQQRQQRERLLAASQRLEELLRRHGWPPAGGSALFQRLVDPRCAALHDYLARRGILTRQFEQPASLRLGLPADEAAWARLDAALLGFKEPAHE
References
External Links:
Resource Link
Genome ID: PA1276
Entrez Gene ID: 881414
NCBI Protein ID: 15596473
General Reference: PaperBLAST - Find papers about PA1276 and its homologs