Multifunctional protein surE (PA3625)

Identification
Name: Multifunctional protein surE
Synonyms:
  • Stationary-phase survival protein surE
  • 5'/3'-nucleotidase
  • Nucleoside monophosphate phosphohydrolase
  • Exopolyphosphatase
Gene Name: surE
Enzyme Class:
Biological Properties
General Function: Involved in hydrolase activity
Specific Function: Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'- monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP. Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain- length substrates (P20-25). Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs. Also plays a significant physiological role in stress-response and is required for the survival of E.coli in stationary growth phase
Cellular Location: Cytoplasm (Potential)
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb → Thumb+Thumb
5-Thymidylic acid + Water → Phosphate + Thymidine
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Thumb+Thumb → Thumb+Thumb
Deoxyadenosine monophosphate + Water → Deoxyadenosine + Phosphate
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Thumb+Thumb → Thumb+Thumb
2'-Deoxyguanosine 5'-monophosphate + Water → Deoxyguanosine + Phosphate
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Thumb+Thumb → Thumb+Thumb
dCMP + Water → Deoxycytidine + Phosphate
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Thumb+Thumb → Thumb+Thumb
Water + Uridine 5'-monophosphate → Phosphate + Uridine
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Thumb+Thumb → Thumb+Thumb
Adenosine monophosphate + Water → Adenosine + Phosphate
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Thumb+Thumb → Thumb+Thumb
Cytidine monophosphate + Water → Cytidine + Phosphate
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Thumb+Thumb → Thumb+Thumb
Water + Xanthylic acid → Phosphate + Xanthosine
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Thumb+Thumb → Thumb+Thumb
Water + Inosinic acid → Inosine + Phosphate
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Thumb+Thumb → Thumb+Thumb
Guanosine monophosphate + Water → Guanosine + Phosphate
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Thumb+Thumb ↔ Thumb+Thumb
Adenosine monophosphate + Water ↔ Adenosine + Phosphate
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Thumb+Thumb ↔ Thumb+Thumb
Cytidine monophosphate + Water ↔ Cytidine + Phosphate
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Thumb+Thumb ↔ Thumb+Thumb
Uridine 5'-monophosphate + Water ↔ Uridine + Phosphate
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Thumb+Thumb ↔ Thumb+Thumb
Inosinic acid + Water ↔ Inosine + Phosphate
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Thumb+Thumb ↔ Thumb+Thumb
Guanosine monophosphate + Water ↔ Guanosine + Phosphate
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Thumb+Thumb ↔ Thumb+Thumb
5-Thymidylic acid + Water ↔ Thymidine + Phosphate
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Thumb+Thumb ↔ Thumb+Thumb
dCMP + Water ↔ Deoxycytidine + Phosphate
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Thumb+Thumb ↔ Thumb+Thumb
2'-Deoxyguanosine 5'-monophosphate + Water ↔ Deoxyguanosine + Phosphate
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Thumb+Thumb ↔ Thumb+Thumb
Deoxyadenosine monophosphate + Water ↔ Deoxyadenosine + Phosphate
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Thumb+Thumb ↔ Thumb+Thumb
Nicotinamide ribotide + Water ↔ Nicotinamide riboside + Phosphate
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Thumb+Thumb ↔ Thumb+Thumb
Xanthylic acid + Water ↔ Xanthosine + Phosphate
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5'-Ribonucleotide+Thumb ↔ Thumb+Thumb
5'-Ribonucleotide + Water ↔ Ribonucleoside + Phosphate
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SMPDB Reactions: Not Available
PseudoCyc/BioCyc Reactions:
Thumb+Thumb → Thumb+Thumb
dCMP + Water → Deoxycytidine + Phosphate
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Thumb+Thumb → Thumb+2 Thumb
Water + Pyrophosphate → Hydrogen ion + 2 Phosphate
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Thumb+Thumb → Thumb+Thumb
Adenosine monophosphate + Water → Adenosine + Phosphate
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Thumb+Thumb → Thumb+Thumb
Water + Inosinic acid → Inosine + Phosphate
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Thumb+Thumb → Thumb+Thumb
Guanosine monophosphate + Water → Guanosine + Phosphate
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Thumb+Thumb ↔ Thumb+Thumb
dCMP + Water ↔ Deoxycytidine + Phosphate
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a nucleoside 3'-phosphate+Thumb → a ribonucleoside+Thumb
a nucleoside 3'-phosphate + Water → a ribonucleoside + Phosphate
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a ribonucleoside monophosphate+Thumb → a ribonucleoside+Thumb
a ribonucleoside monophosphate + Water → a ribonucleoside + Phosphate
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Complex Reactions:
Thumb+Thumb → Thumb+Thumb
dUMP + Water → Deoxyuridine + Phosphate
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Thumb+Thumb → Thumb+Thumb
DIMP + Water → Deoxyinosine + Phosphate
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Thumb+Thumb → Thumb+Thumb+Thumb
Water + Triphosphate → Hydrogen ion + Phosphate + Pyrophosphate
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A 3'-ribonucleotide+Thumb → a ribonucleoside+Thumb
A 3'-ribonucleotide + Water → a ribonucleoside + Inorganic phosphate
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A 5'-ribonucleotide+Thumb → a ribonucleoside+Thumb
A 5'-ribonucleotide + Water → a ribonucleoside + Inorganic phosphate
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(Polyphosphate)(n)+Thumb → (polyphosphate)(n-1)+Thumb
(Polyphosphate)(n) + Water → (polyphosphate)(n-1) + Inorganic phosphate
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Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB0002312'-Deoxyguanosine 5'-monophosphateMetaboCard
PAMDB0003035-Thymidylic acidMetaboCard
PAMDB000016AdenosineMetaboCard
PAMDB000014Adenosine monophosphateMetaboCard
PAMDB000033CytidineMetaboCard
PAMDB000035Cytidine monophosphateMetaboCard
PAMDB000297dCMPMetaboCard
PAMDB000039DeoxyadenosineMetaboCard
PAMDB000199Deoxyadenosine monophosphateMetaboCard
PAMDB000003DeoxycytidineMetaboCard
PAMDB000031DeoxyguanosineMetaboCard
PAMDB000024DeoxyinosineMetaboCard
PAMDB000002DeoxyuridineMetaboCard
PAMDB000681DIMPMetaboCard
PAMDB000375dUMPMetaboCard
PAMDB000052GuanosineMetaboCard
PAMDB000369Guanosine monophosphateMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB001776Inorganic phosphateMetaboCard
PAMDB000082InosineMetaboCard
PAMDB000601Inosinic acidMetaboCard
PAMDB000194Nicotinamide ribosideMetaboCard
PAMDB000095Nicotinamide ribotideMetaboCard
PAMDB003612NMNMetaboCard
PAMDB000383PhosphateMetaboCard
PAMDB000633PyrophosphateMetaboCard
PAMDB000114ThymidineMetaboCard
PAMDB000496TriphosphateMetaboCard
PAMDB000124UridineMetaboCard
PAMDB000118Uridine 5'-monophosphateMetaboCard
PAMDB000142WaterMetaboCard
PAMDB000125XanthosineMetaboCard
PAMDB000419Xanthylic acidMetaboCard
GO Classification:
Function
catalytic activity
hydrolase activity
Gene Properties
Locus tag: PA3625
Strand: -
Entrez Gene ID: 880442
Accession: NP_252315.1
GI: 15598821
Sequence start: 4060625
Sequence End: 4061374
Sequence Length: 749
Gene Sequence: 
>PA3625
ATGCGCATACTGATTGCCAACGACGACGGGGTGACCGCACCCGGTATCGCCGCGCTTTACGACGCGCTGGCGGATCATGCCGATTGCGTAGTGATCGCCCCCGACCAGGACAAGAGCGGCGCCAGCAGTTCCCTGACGCTGGACCGCCCGCTGCACCCGCAGCGCCTGGACAACGGATTCATCAGCCTCAACGGCACGCCGACCGACTGCGTGCACCTGGGCCTGAACGGCTTGCTGGAGGAATTGCCGGACATGGTGGTCTCGGGTATCAACCTGGGCGCCAACCTCGGCGATGACGTCCTCTATTCCGGTACCGTGGCGGCGGCCATCGAAGGGCGCTTCCTGAAGGGGCCGGCCTTCGCCTTCTCGCTGGTCTCGCGGTTGACGGACAACCTGCCCACCGCCATGCACTTCGCCCGCCTGCTGGTCTCCGCCCACGAGCGCCTGGCCGTGCCGCCGCGTACCGTGCTCAACGTCAATATCCCGAACCTGCCGCTGGATCGCGTACGTGGTATCCAACTGACCCGCCTCGGGCACCGCGCCCGTGCCGCCGCACCGGTGAAGGTGGTCAATCCGCGCGGCAAGGAAGGCTACTGGATCGCCGCGGCCGGCGATGCCGAGGATGGCGGGCCGGGGACGGATTTCCACGCGGTCATGCAAGGCTACGTGTCGATCACCCCGTTGCAGCTGGACCGCACCTTCCACGAAGCCTTCGGCGGCCTCGACGAGTGGCTGGGAGGACTGACGTGA
Protein Properties
Protein Residues: 249
Protein Molecular Weight: 26.4 kDa
Protein Theoretical pI: 5.24
Hydropathicity (GRAVY score): 0.073
Charge at pH 7 (predicted): -7.14
Protein Sequence: 
>PA3625
MRILIANDDGVTAPGIAALYDALADHADCVVIAPDQDKSGASSSLTLDRPLHPQRLDNGFISLNGTPTDCVHLGLNGLLEELPDMVVSGINLGANLGDDVLYSGTVAAAIEGRFLKGPAFAFSLVSRLTDNLPTAMHFARLLVSAHERLAVPPRTVLNVNIPNLPLDRVRGIQLTRLGHRARAAAPVKVVNPRGKEGYWIAAAGDAEDGGPGTDFHAVMQGYVSITPLQLDRTFHEAFGGLDEWLGGLT
References
External Links:
Resource Link
Genome ID: PA3625
Entrez Gene ID: 880442
NCBI Protein ID: 15598821
General Reference: PaperBLAST - Find papers about PA3625 and its homologs