Histidyl-tRNA synthetase (PA3802)

Identification
Name: Histidyl-tRNA synthetase
Synonyms:
  • Histidine--tRNA ligase
  • HisRS
Gene Name: hisS
Enzyme Class:
Biological Properties
General Function: Involved in nucleotide binding
Specific Function: ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His)
Cellular Location: Cytoplasm
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb+tRNA(His)+tRNA(His) ↔ Thumb+L-Histidyl-tRNA(His)+Thumb+Thumb
Adenosine triphosphate + L-Histidine + tRNA(His) + tRNA(His) ↔ Adenosine monophosphate + L-Histidyl-tRNA(His) + Pyrophosphate + L-Histidyl-tRNA(His)
ReactionCard
Thumb+Thumb+tRNA(His) ↔ Thumb+Thumb+L-Histidyl-tRNA(His)
Adenosine triphosphate + L-Histidine + tRNA(His) ↔ Adenosine monophosphate + Pyrophosphate + L-Histidyl-tRNA(His)
ReactionCard
SMPDB Reactions:
L-Histidine+Thumb+Thumb+tRNA(His)+Thumb → Thumb+Pyrophosphate+L-histidyl-tRNA(His)
L-Histidine + Adenosine triphosphate + Hydrogen ion + tRNA(His) + L-Histidine → Adenosine monophosphate + Pyrophosphate + L-histidyl-tRNA(His)
ReactionCard
PseudoCyc/BioCyc Reactions:
Thumb+Thumb+tRNA(His)+tRNA(His) ↔ Thumb+L-Histidyl-tRNA(His)+Thumb+Thumb
Adenosine triphosphate + L-Histidine + tRNA(His) + tRNA(His) ↔ Adenosine monophosphate + L-Histidyl-tRNA(His) + Pyrophosphate + L-Histidyl-tRNA(His)
ReactionCard
Thumb+Thumb+tRNA(His) ↔ Thumb+Thumb+L-Histidyl-tRNA(His)
Adenosine triphosphate + L-Histidine + tRNA(His) ↔ Adenosine monophosphate + Pyrophosphate + L-Histidyl-tRNA(His)
ReactionCard
Thumb+Thumb+tRNA(His) → Thumb+Thumb+L-histidyl-tRNA(His)
Adenosine triphosphate + L-Histidine + tRNA(His) → Adenosine monophosphate + Pyrophosphate + L-histidyl-tRNA(His)
ReactionCard
L-Histidine+Thumb+Thumb+tRNA(His)+Thumb → Thumb+Pyrophosphate+L-histidyl-tRNA(His)
L-Histidine + Adenosine triphosphate + Hydrogen ion + tRNA(His) + L-Histidine → Adenosine monophosphate + Pyrophosphate + L-histidyl-tRNA(His)
ReactionCard
Thumb
a tRNAhis + L-histidine + ATP + H+ → an L-histidyl-[tRNAhis] + AMP + diphosphate
ReactionCard
Complex Reactions:
Thumb+Thumb+tRNA(His) → Thumb+Thumb+L-histidyl-tRNA(His)
Adenosine triphosphate + L-Histidine + tRNA(His) → Adenosine monophosphate + Pyrophosphate + L-histidyl-tRNA(His)
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB000014Adenosine monophosphateMetaboCard
PAMDB000148Adenosine triphosphateMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB000074L-HistidineMetaboCard
PAMDB004273L-Histidyl-tRNA(His)MetaboCard
PAMDB000633PyrophosphateMetaboCard
GO Classification:
Component
cell part
cytoplasm
intracellular part
Function
adenyl nucleotide binding
adenyl ribonucleotide binding
aminoacyl-tRNA ligase activity
ATP binding
binding
catalytic activity
histidine-tRNA ligase activity
ligase activity
ligase activity, forming aminoacyl-tRNA and related compounds
ligase activity, forming carbon-oxygen bonds
nucleoside binding
nucleotide binding
purine nucleoside binding
Process
biosynthetic process
cellular macromolecule biosynthetic process
cellular macromolecule metabolic process
histidyl-tRNA aminoacylation
macromolecule biosynthetic process
macromolecule metabolic process
metabolic process
ncRNA metabolic process
RNA metabolic process
translation
tRNA aminoacylation
tRNA aminoacylation for protein translation
tRNA metabolic process
Gene Properties
Locus tag: PA3802
Strand: -
Entrez Gene ID: 878330
Accession: NP_252491.1
GI: 15598997
Sequence start: 4261070
Sequence End: 4262359
Sequence Length: 1289
Gene Sequence: 
>PA3802
GTGAGCAAGTCCCTGCAAGCCATTCGTGGCATGAACGACATCCTGCCGGAACAGACTCCGGCCTGGCGCTATCTGGAACGCACCTTCGCCGGCCTGCTGGACGGTTACGGCTACAGCGAGATCCGCCTGCCCATCCTCGAGTTCACCGAACTCTTCGCCCGCGGCATCGGCGAAGGCACCGATGTGGTCGACAAGGAGATGTACACCTTCCTCGACCGCAACGGCGAATCCCTGACCATGCGTCCGGAAGGTACCGCCGGTTGCGTGCGCGCCGTGCTGGAGCACGGCCTGAGCGGCGGTGGCCAGGTGCAGAAGCTCTGGTACACCGGGCCGATGTTCCGTTACGAGAAACCGCAGAAAGGTCGCTACCGGCAGTTCCACCAGATCGGCGTGGAAGTCTTCAACCTGCCCGGTCCGGACATCGACGCCGAGTTGATCATCCTCACCTGGCGCCTGTGGCAGAAGCTCGGCATGGCCGACGCGGTGACCCTGCAGCTCAACACCCTCGGCTCCAGCGAGGCCCGCGCACGCTATCGCGAGGCCCTGGTGGCCTATCTGCAGGAGCGCTTCGAGCAACTCGACGAAGACAGCCAGCGGCGCATGACCACCAATCCGCTGCGAATCCTCGACAGCAAGGTGGAGAGCACCCAGGCGTTGCTGGTTGGCGCGCCGACCCTGCACGACTATCTCGACGAAGAATCGATCGCCCACTTCGAGGGTCTCAAGGCCCGCCTGGATGCTGTCGGACTTCGCTACGAAATCAACCAGAAGCTGGTGCGCGGCCTGGACTATTACTGCCGCACGGCTTTCGAGTGGGTCACCGACAAGCTTGGCGCCCAGGGCACCGTTTGCGGCGGTGGCCGCTACGACGGGCTGGTCAGCCAGTTCGGCGGCAAGCCGACCCCGGGTGTCGGTTTCGCCATGGGCGTGGAACGCCTGGTGCTGCTGCTGGAAACCTTGGGGGTGATCCCCGCCGAACTGAACCGTCCGGCCGACCTCTACGTCTGCGCCTTCGGCGAACCGGCCGAGCTGGCCGCCCTGACCCTGGCCGAACAGTTGCGCAGCGCCATTCCCGGCATACGCCTGCTGGTCAACGCCGGCGCCGGTAGCTTCAAGAGCCAGTTCAAGAAGGCCGACAAGAGCGGCGCGCGCTTTGCCCTGATCCTCGGGGAGGACGAGGTGGCCAATCGCGTGGTAGGTTTCAAGCCCCTGCGTGACGAGGGCGAGCAACAAAGCATTGCCTGGGATGCTCTGCCCGAGCACCTGGCAGCCTGTCTGGCACAGGCTTGA
Protein Properties
Protein Residues: 429
Protein Molecular Weight: 47.5 kDa
Protein Theoretical pI: 5.04
Hydropathicity (GRAVY score): -0.178
Charge at pH 7 (predicted): -8.93
Protein Sequence: 
>PA3802
MSKSLQAIRGMNDILPEQTPAWRYLERTFAGLLDGYGYSEIRLPILEFTELFARGIGEGTDVVDKEMYTFLDRNGESLTMRPEGTAGCVRAVLEHGLSGGGQVQKLWYTGPMFRYEKPQKGRYRQFHQIGVEVFNLPGPDIDAELIILTWRLWQKLGMADAVTLQLNTLGSSEARARYREALVAYLQERFEQLDEDSQRRMTTNPLRILDSKVESTQALLVGAPTLHDYLDEESIAHFEGLKARLDAVGLRYEINQKLVRGLDYYCRTAFEWVTDKLGAQGTVCGGGRYDGLVSQFGGKPTPGVGFAMGVERLVLLLETLGVIPAELNRPADLYVCAFGEPAELAALTLAEQLRSAIPGIRLLVNAGAGSFKSQFKKADKSGARFALILGEDEVANRVVGFKPLRDEGEQQSIAWDALPEHLAACLAQA
References
External Links:
Resource Link
Genome ID: PA3802
Entrez Gene ID: 878330
NCBI Protein ID: 15598997
General Reference: PaperBLAST - Find papers about PA3802 and its homologs