Identification |
Name: |
Histidyl-tRNA synthetase |
Synonyms: |
- Histidine--tRNA ligase
- HisRS
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Gene Name: |
hisS |
Enzyme Class: |
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Biological Properties |
General Function: |
Involved in nucleotide binding |
Specific Function: |
ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His) |
Cellular Location: |
Cytoplasm |
KEGG Pathways: |
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KEGG Reactions: |
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![Thumb](/molecules/PAMDB000148thumb.png) | + | ![Thumb](/molecules/PAMDB000074thumb.png) | + | tRNA(His) | + | tRNA(His) | ↔ | ![Thumb](/molecules/PAMDB000014thumb.png) | + | L-Histidyl-tRNA(His) | + | ![Thumb](/molecules/PAMDB000633thumb.png) | + | ![Thumb](/molecules/PAMDB004273thumb.png) |
| | |
![Thumb](/molecules/PAMDB000148thumb.png) | + | ![Thumb](/molecules/PAMDB000074thumb.png) | + | tRNA(His) | ↔ | ![Thumb](/molecules/PAMDB000014thumb.png) | + | ![Thumb](/molecules/PAMDB000633thumb.png) | + | L-Histidyl-tRNA(His) |
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SMPDB Reactions: |
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L-Histidine | + | ![Thumb](/molecules/PAMDB000148thumb.png) | + | ![Thumb](/molecules/PAMDB001633thumb.png) | + | tRNA(His) | + | ![Thumb](/molecules/PAMDB000074thumb.png) | → | ![Thumb](/molecules/PAMDB000014thumb.png) | + | Pyrophosphate | + | L-histidyl-tRNA(His) |
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PseudoCyc/BioCyc Reactions: |
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Complex Reactions: |
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![Thumb](/molecules/PAMDB000148thumb.png) | + | ![Thumb](/molecules/PAMDB000074thumb.png) | + | tRNA(His) | → | ![Thumb](/molecules/PAMDB000014thumb.png) | + | ![Thumb](/molecules/PAMDB000633thumb.png) | + | L-histidyl-tRNA(His) |
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Transports: |
Not Available |
Metabolites: |
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GO Classification: |
Component |
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cell part | cytoplasm | intracellular part | Function |
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adenyl nucleotide binding | adenyl ribonucleotide binding | aminoacyl-tRNA ligase activity | ATP binding | binding | catalytic activity | histidine-tRNA ligase activity | ligase activity | ligase activity, forming aminoacyl-tRNA and related compounds | ligase activity, forming carbon-oxygen bonds | nucleoside binding | nucleotide binding | purine nucleoside binding | Process |
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biosynthetic process | cellular macromolecule biosynthetic process | cellular macromolecule metabolic process | histidyl-tRNA aminoacylation | macromolecule biosynthetic process | macromolecule metabolic process | metabolic process | ncRNA metabolic process | RNA metabolic process | translation | tRNA aminoacylation | tRNA aminoacylation for protein translation | tRNA metabolic process |
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Gene Properties |
Locus tag: |
PA3802 |
Strand: |
- |
Entrez Gene ID: |
878330 |
Accession: |
NP_252491.1 |
GI: |
15598997 |
Sequence start: |
4261070 |
Sequence End: |
4262359 |
Sequence Length: |
1289 |
Gene Sequence: |
>PA3802
GTGAGCAAGTCCCTGCAAGCCATTCGTGGCATGAACGACATCCTGCCGGAACAGACTCCGGCCTGGCGCTATCTGGAACGCACCTTCGCCGGCCTGCTGGACGGTTACGGCTACAGCGAGATCCGCCTGCCCATCCTCGAGTTCACCGAACTCTTCGCCCGCGGCATCGGCGAAGGCACCGATGTGGTCGACAAGGAGATGTACACCTTCCTCGACCGCAACGGCGAATCCCTGACCATGCGTCCGGAAGGTACCGCCGGTTGCGTGCGCGCCGTGCTGGAGCACGGCCTGAGCGGCGGTGGCCAGGTGCAGAAGCTCTGGTACACCGGGCCGATGTTCCGTTACGAGAAACCGCAGAAAGGTCGCTACCGGCAGTTCCACCAGATCGGCGTGGAAGTCTTCAACCTGCCCGGTCCGGACATCGACGCCGAGTTGATCATCCTCACCTGGCGCCTGTGGCAGAAGCTCGGCATGGCCGACGCGGTGACCCTGCAGCTCAACACCCTCGGCTCCAGCGAGGCCCGCGCACGCTATCGCGAGGCCCTGGTGGCCTATCTGCAGGAGCGCTTCGAGCAACTCGACGAAGACAGCCAGCGGCGCATGACCACCAATCCGCTGCGAATCCTCGACAGCAAGGTGGAGAGCACCCAGGCGTTGCTGGTTGGCGCGCCGACCCTGCACGACTATCTCGACGAAGAATCGATCGCCCACTTCGAGGGTCTCAAGGCCCGCCTGGATGCTGTCGGACTTCGCTACGAAATCAACCAGAAGCTGGTGCGCGGCCTGGACTATTACTGCCGCACGGCTTTCGAGTGGGTCACCGACAAGCTTGGCGCCCAGGGCACCGTTTGCGGCGGTGGCCGCTACGACGGGCTGGTCAGCCAGTTCGGCGGCAAGCCGACCCCGGGTGTCGGTTTCGCCATGGGCGTGGAACGCCTGGTGCTGCTGCTGGAAACCTTGGGGGTGATCCCCGCCGAACTGAACCGTCCGGCCGACCTCTACGTCTGCGCCTTCGGCGAACCGGCCGAGCTGGCCGCCCTGACCCTGGCCGAACAGTTGCGCAGCGCCATTCCCGGCATACGCCTGCTGGTCAACGCCGGCGCCGGTAGCTTCAAGAGCCAGTTCAAGAAGGCCGACAAGAGCGGCGCGCGCTTTGCCCTGATCCTCGGGGAGGACGAGGTGGCCAATCGCGTGGTAGGTTTCAAGCCCCTGCGTGACGAGGGCGAGCAACAAAGCATTGCCTGGGATGCTCTGCCCGAGCACCTGGCAGCCTGTCTGGCACAGGCTTGA |
Protein Properties |
Protein Residues: |
429 |
Protein Molecular Weight: |
47.5 kDa |
Protein Theoretical pI: |
5.04 |
Hydropathicity (GRAVY score): |
-0.178 |
Charge at pH 7 (predicted): |
-8.93 |
Protein Sequence: |
>PA3802
MSKSLQAIRGMNDILPEQTPAWRYLERTFAGLLDGYGYSEIRLPILEFTELFARGIGEGTDVVDKEMYTFLDRNGESLTMRPEGTAGCVRAVLEHGLSGGGQVQKLWYTGPMFRYEKPQKGRYRQFHQIGVEVFNLPGPDIDAELIILTWRLWQKLGMADAVTLQLNTLGSSEARARYREALVAYLQERFEQLDEDSQRRMTTNPLRILDSKVESTQALLVGAPTLHDYLDEESIAHFEGLKARLDAVGLRYEINQKLVRGLDYYCRTAFEWVTDKLGAQGTVCGGGRYDGLVSQFGGKPTPGVGFAMGVERLVLLLETLGVIPAELNRPADLYVCAFGEPAELAALTLAEQLRSAIPGIRLLVNAGAGSFKSQFKKADKSGARFALILGEDEVANRVVGFKPLRDEGEQQSIAWDALPEHLAACLAQA |
References |
External Links: |
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General Reference: |
PaperBLAST - Find papers about PA3802 and its homologs
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