Identification
Name: Arginyl-tRNA synthetase
Synonyms:
  • Arginine--tRNA ligase
  • ArgRS
Gene Name: argS
Enzyme Class:
Biological Properties
General Function: Involved in nucleotide binding
Specific Function: ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)
Cellular Location: Cytoplasm
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb+tRNA(Arg)+tRNA(Arg)Thumb+L-Arginyl-tRNA(Arg)+Thumb+L-Arginyl-tRNA(Arg)
L-Arginine + Adenosine triphosphate + tRNA(Arg) + tRNA(Arg) ↔ Adenosine monophosphate + L-Arginyl-tRNA(Arg) + Pyrophosphate + L-Arginyl-tRNA(Arg)
ReactionCard
Thumb+Thumb+tRNA(Arg)Thumb+Thumb+L-Arginyl-tRNA(Arg)
SMPDB Reactions:
Thumb+tRNA(Arg)+Thumb+ThumbPyrophosphate+Thumb+L-arginyl-tRNA(Arg)
L-Arginine + tRNA(Arg) + Adenosine triphosphate + Hydrogen ion → Pyrophosphate + Adenosine monophosphate + L-arginyl-tRNA(Arg)
ReactionCard
PseudoCyc/BioCyc Reactions:
Thumb+Thumb+tRNA(Arg)+tRNA(Arg)Thumb+L-Arginyl-tRNA(Arg)+Thumb+L-Arginyl-tRNA(Arg)
L-Arginine + Adenosine triphosphate + tRNA(Arg) + tRNA(Arg) ↔ Adenosine monophosphate + L-Arginyl-tRNA(Arg) + Pyrophosphate + L-Arginyl-tRNA(Arg)
ReactionCard
Thumb+Thumb+tRNA(Arg)Thumb+Thumb+L-Arginyl-tRNA(Arg)
Thumb+Thumb+tRNA(Arg)Thumb+Thumb+L-arginyl-tRNA(Arg)
Thumb+tRNA(Arg)+Thumb+ThumbPyrophosphate+Thumb+L-arginyl-tRNA(Arg)
L-Arginine + tRNA(Arg) + Adenosine triphosphate + Hydrogen ion → Pyrophosphate + Adenosine monophosphate + L-arginyl-tRNA(Arg)
ReactionCard
Thumb
a tRNAarg + L-arginine + ATP + H+ → an L-arginyl-[tRNAarg] + AMP + diphosphate
ReactionCard
Complex Reactions:
Thumb+Thumb+tRNA(Arg)Thumb+Thumb+L-arginyl-tRNA(Arg)
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB000014Adenosine monophosphateMetaboCard
PAMDB000148Adenosine triphosphateMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB000146L-ArginineMetaboCard
PAMDB000633PyrophosphateMetaboCard
GO Classification:
Component
cell part
cytoplasm
intracellular part
Function
adenyl nucleotide binding
adenyl ribonucleotide binding
aminoacyl-tRNA ligase activity
arginine-tRNA ligase activity
ATP binding
binding
catalytic activity
ligase activity
ligase activity, forming aminoacyl-tRNA and related compounds
ligase activity, forming carbon-oxygen bonds
nucleoside binding
nucleotide binding
purine nucleoside binding
Process
arginyl-tRNA aminoacylation
biosynthetic process
cellular macromolecule biosynthetic process
cellular macromolecule metabolic process
macromolecule biosynthetic process
macromolecule metabolic process
metabolic process
ncRNA metabolic process
RNA metabolic process
translation
tRNA aminoacylation
tRNA aminoacylation for protein translation
tRNA metabolic process
Gene Properties
Locus tag: PA5051
Strand: +
Entrez Gene ID: 881194
Accession: NP_253738.1
GI: 15600244
Sequence start: 5689964
Sequence End: 5691727
Sequence Length: 1763
Gene Sequence:
>PA5051
ATGAAAGACACGATTCGCCAGCTGATCCAGCAAGCCCTCGACCAACTGACCGCGGACGGCACCCTGCCCGCCGGCCTGACCCCGGACATCCAGGTGGAGAACACCAAGGACCGTAGCCACGGCGATTTCGCCAGCAACATCGCCATGATGCTGGCCAAGCCGGCCGGGATGAAGCCGCGCGACCTGGCCGCCAGGCTGGTCGAGGCAATCCCCGCCCACGAGCAACTGGCCAAGGTGGAGATCGCCGGTCCCGGCTTCCTCAACTTCTTCCAGGATCACGTCTGGCTCGCCGCCAGCCTCGACCGCGCCCTCGCCGACGAACGTCTCGGCGTGCGCAAGGCAGGCCCGGCGCAGCGCGTGGTGATCGACCTGTCCTCGCCGAACCTGGCCAAGGAAATGCACGTCGGCCACCTGCGCTCGACCATCATCGGCGACGCCGTCGCGCGCGTCCTCGAGTTCCTCGGCGACACGGTGATCCGGCAGAACCATGTCGGCGACTGGGGCACCCAGTTCGGCATGCTGCTCGCCTACCTGGAAGAGCAACCGGTCGACGCCGAGGCCGAGCTGCACGACCTGGAGGTCTTCTACCGCGCGGCGAAGAAACGCTTCGACGAGTCTCCCGAATTCGCCGACCGCGCCCGCGAACTGGTAGTCAAGCTGCAGGCCGGCGACCCCGACTGCCTGCGCCTGTGGACCCGCTTCAACGAGATTTCCCTGTCGCACTGCCAGAAGGTCTACGACCGTCTCGGCGTGAAGCTGAGCATGGCCGACGTCATGGGCGAGAGCGCCTACAACGACGACCTCGCCCAGGTGGTCGCCGACCTGACCGCCAAGGGCCTGCTCACCGAAGACAACGGCGCGTTGTGCGTCTTCCTCGAAGAGTTCAAGAACGCCGAGGGCAATCCGCTCCCGGTGATCGTGCAGAAGGCCGGCGGCGGCTACCTCTACGCCACCACCGACCTCGCCGCCATGCGTTATCGGCACAACGTGCTGCACGCCGACCGCGTGCTGTACTTCGTCGACCAGCGCCAGGCCCTGCACTTCCAGCAGGTCTTCGAAGTGGCGCGGCGCGCCGGTTTCGTTCCGGCCGGCATGGAGCTGGAGCACATGGGCTTCGGCACCATGAACGGCGCCGACGGCCGTCCGTTCAAGACCCGCGACGGCGGTACGGTGAAGCTGATCGACCTGCTGGAAGAGGCCGAGAGCCGCGCCTATGCGCTGGTCAAGGAACGCAACGAGCAGCGCGCCGAGCGTGGCGAGGAGCCGTTCGACGAGGTCCAGCTGCGCGAGATCGGCCGGGTGGTGGGGATCGACTCGGTGAAGTACGCCGACCTGTCCAAGCACCGCACCAGCGACTACAGCTTCAACTTCGAACTGATGCTGAGCTTCGAAGGCAACACCGCACCCTACCTGCTCTACGCCTGCACCCGCGTGGCCAGCGTCTTCCGCAAGCTCGGCCAGGGCCGCGAGCAACTGGGCGGGAAGATCGTCCTCGAGCAGCCCCAGGAGCTGGCCCTGGCCGCACAGCTGGCGCAGTTCGGCGACCTGATCAACAACGTCGCGCTCAAGGGCGTGCCGCACCTGCTCTGCGCCTACCTGTACGAGTTGGCCGGGCTGTTCTCCAGCTTCTACGAGCATTGCCCGATCCTCACCGCCGAGGACCCGGCGCAGAAGGACAGCCGCCTGCGTCTCGCCGCGCTGACCGGCCGTACCCTGGAACAGGGCCTGGAGCTGCTCGGTCTGAAGACTCTGGAACGCATGTAA
Protein Properties
Protein Residues: 587
Protein Molecular Weight: 65.2 kDa
Protein Theoretical pI: 5.24
Hydropathicity (GRAVY score): -0.187
Charge at pH 7 (predicted): -15.53
Protein Sequence:
>PA5051
MKDTIRQLIQQALDQLTADGTLPAGLTPDIQVENTKDRSHGDFASNIAMMLAKPAGMKPRDLAARLVEAIPAHEQLAKVEIAGPGFLNFFQDHVWLAASLDRALADERLGVRKAGPAQRVVIDLSSPNLAKEMHVGHLRSTIIGDAVARVLEFLGDTVIRQNHVGDWGTQFGMLLAYLEEQPVDAEAELHDLEVFYRAAKKRFDESPEFADRARELVVKLQAGDPDCLRLWTRFNEISLSHCQKVYDRLGVKLSMADVMGESAYNDDLAQVVADLTAKGLLTEDNGALCVFLEEFKNAEGNPLPVIVQKAGGGYLYATTDLAAMRYRHNVLHADRVLYFVDQRQALHFQQVFEVARRAGFVPAGMELEHMGFGTMNGADGRPFKTRDGGTVKLIDLLEEAESRAYALVKERNEQRAERGEEPFDEVQLREIGRVVGIDSVKYADLSKHRTSDYSFNFELMLSFEGNTAPYLLYACTRVASVFRKLGQGREQLGGKIVLEQPQELALAAQLAQFGDLINNVALKGVPHLLCAYLYELAGLFSSFYEHCPILTAEDPAQKDSRLRLAALTGRTLEQGLELLGLKTLERM
References
External Links:
Resource Link
Genome ID: PA5051
Entrez Gene ID: 881194
NCBI Protein ID: 15600244
General Reference: PaperBLAST - Find papers about PA5051 and its homologs