Phosphopantetheine adenylyltransferase (PA0363)

Identification
Name: Phosphopantetheine adenylyltransferase
Synonyms:
  • Dephospho-CoA pyrophosphorylase
  • Pantetheine-phosphate adenylyltransferase
  • PPAT
Gene Name: coaD
Enzyme Class:
Biological Properties
General Function: Involved in catalytic activity
Specific Function: Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Cellular Location: Cytoplasm
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb+Thumb ↔ Thumb+Thumb
Adenosine triphosphate + Hydrogen ion + Pantetheine 4'-phosphate ↔ Dephospho-CoA + Pyrophosphate
ReactionCard
Thumb+Thumb ↔ Thumb+Thumb
Adenosine triphosphate + Pantetheine 4'-phosphate ↔ Pyrophosphate + Dephospho-CoA
ReactionCard
SMPDB Reactions:
4'-phosphopantetheine+Thumb+Thumb+Thumb → Pyrophosphate+Thumb
4'-phosphopantetheine + Adenosine triphosphate + Hydrogen ion + 4'-phosphopantetheine → Pyrophosphate + Dephospho-CoA
ReactionCard
PseudoCyc/BioCyc Reactions:
Thumb+Thumb+Thumb ↔ Thumb+Thumb
Adenosine triphosphate + Hydrogen ion + Pantetheine 4'-phosphate ↔ Dephospho-CoA + Pyrophosphate
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Complex Reactions:
Thumb+Thumb → Thumb+Thumb
Adenosine triphosphate + pantotheine 4'-phosphate → Pyrophosphate + 3'-dephospho-CoA
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB0035593'-dephospho-CoAMetaboCard
PAMDB0063304'-phosphopantetheineMetaboCard
PAMDB000148Adenosine triphosphateMetaboCard
PAMDB000362Dephospho-CoAMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB000379Pantetheine 4'-phosphateMetaboCard
PAMDB003606pantotheine 4'-phosphateMetaboCard
PAMDB000633PyrophosphateMetaboCard
GO Classification:
Function
adenylyltransferase activity
catalytic activity
nucleotidyltransferase activity
pantetheine-phosphate adenylyltransferase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
Process
biosynthetic process
cellular metabolic process
coenzyme A biosynthetic process
coenzyme biosynthetic process
coenzyme metabolic process
cofactor metabolic process
metabolic process
Gene Properties
Locus tag: PA0363
Strand: -
Entrez Gene ID: 879847
Accession: NP_249054.1
GI: 15595560
Sequence start: 406619
Sequence End: 407098
Sequence Length: 479
Gene Sequence: 
>PA0363
ATGAACCGAGTGCTGTACCCAGGCACCTTCGATCCCATCACCAAGGGTCACGGCGATCTGATCGAACGTGCTTCACGGCTTTTCGACCATGTGATCATCGCGGTCGCCGCCAGCCCCAAGAAGAACCCCCTGTTCAGCCTGGAACAGCGGGTTGCGCTGGCCCAGGAGGTCACCAAGCACCTGCCGAACGTCGAGGTGGTGGGCTTCTCCACCCTGCTGGCGCACTTCGTCAAGGAGCAGAAGGCGAATGTCTTCCTCCGCGGCCTGCGCGCGGTTTCCGACTTCGAGTACGAGTTCCAGCTGGCCAACATGAACCGCCAGCTCGCCCCCGACGTGGAAAGCATGTTCCTCACCCCGTCGGAGAAGTATTCCTTCATTTCCTCGACGCTGGTCCGGGAAATCGCCGCTCTCGGCGGGGATATCAGCAAGTTCGTGCATCCGGCCGTGGCAGACGCCCTGGCGGAACGTTTCAAGCGCTGA
Protein Properties
Protein Residues: 159
Protein Molecular Weight: 17.8 kDa
Protein Theoretical pI: 8.95
Hydropathicity (GRAVY score): -0.007
Charge at pH 7 (predicted): 2.19
Protein Sequence: 
>PA0363
MNRVLYPGTFDPITKGHGDLIERASRLFDHVIIAVAASPKKNPLFSLEQRVALAQEVTKHLPNVEVVGFSTLLAHFVKEQKANVFLRGLRAVSDFEYEFQLANMNRQLAPDVESMFLTPSEKYSFISSTLVREIAALGGDISKFVHPAVADALAERFKR
References
External Links:
Resource Link
Genome ID: PA0363
Entrez Gene ID: 879847
NCBI Protein ID: 15595560
General Reference: PaperBLAST - Find papers about PA0363 and its homologs