Ribose-phosphate pyrophosphokinase (PA4670)

Identification
Name: Ribose-phosphate pyrophosphokinase
Synonyms:
  • RPPK
  • Phosphoribosyl pyrophosphate synthase
  • P-Rib-PP synthase
  • PRPP synthase
Gene Name: prs
Enzyme Class:
Biological Properties
General Function: Involved in magnesium ion binding
Specific Function: ATP + D-ribose 5-phosphate = AMP + 5-phospho- alpha-D-ribose 1-diphosphate
Cellular Location: Cytoplasm
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb ↔ Thumb+Thumb+Thumb
Adenosine triphosphate + D-Ribose-5-phosphate ↔ Adenosine monophosphate + Hydrogen ion + Phosphoribosyl pyrophosphate
ReactionCard
Thumb+Thumb ↔ Thumb+Thumb
Adenosine triphosphate + D-Ribose-5-phosphate ↔ Adenosine monophosphate + Phosphoribosyl pyrophosphate
ReactionCard
SMPDB Reactions:
Thumb+Thumb → Thumb+Thumb+Thumb
D-Ribose-5-phosphate + Adenosine triphosphate → Hydrogen ion + Adenosine monophosphate + Phosphoribosyl pyrophosphate
ReactionCard
PseudoCyc/BioCyc Reactions:
Thumb+Thumb ↔ Thumb+Thumb+Thumb
Adenosine triphosphate + D-Ribose-5-phosphate ↔ Adenosine monophosphate + Hydrogen ion + Phosphoribosyl pyrophosphate
ReactionCard
Thumb+Thumb ↔ Thumb+Thumb+Thumb
Adenosine triphosphate + D-Ribose-5-phosphate ↔ Hydrogen ion + Phosphoribosyl pyrophosphate + Adenosine monophosphate
ReactionCard
Complex Reactions:
Thumb+Thumb → Thumb+Thumb
Adenosine triphosphate + D-Ribose-5-phosphate → Adenosine monophosphate + Phosphoribosyl pyrophosphate
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB000014Adenosine monophosphateMetaboCard
PAMDB000148Adenosine triphosphateMetaboCard
PAMDB000431D-Ribose-5-phosphateMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB000115Phosphoribosyl pyrophosphateMetaboCard
GO Classification:
Function
binding
catalytic activity
cation binding
diphosphotransferase activity
ion binding
magnesium ion binding
metal ion binding
ribose phosphate diphosphokinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
Process
biosynthetic process
cellular biosynthetic process
cellular nitrogen compound metabolic process
metabolic process
nitrogen compound metabolic process
nucleobase, nucleoside and nucleotide metabolic process
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
nucleoside metabolic process
nucleoside monophosphate biosynthetic process
nucleoside monophosphate metabolic process
nucleoside phosphate metabolic process
nucleotide biosynthetic process
nucleotide metabolic process
ribonucleoside monophosphate biosynthetic process
Gene Properties
Locus tag: PA4670
Strand: +
Entrez Gene ID: 881387
Accession: NP_253359.1
GI: 15599865
Sequence start: 5238408
Sequence End: 5239349
Sequence Length: 941
Gene Sequence: 
>PA4670
GTGTCCAAGATGATGGTCTTCACGGGGAACGCTAACCCCGATCTTGCACGACGCGTCGTGCGTCAGCTGCACATTCCTCTTGGCGATGTTTCAGTTGGCAAATTCTCCGATGGCGAAATCAGCGTCGAAATCAACGAAAACGTCCGCGGCAAGGACGTATTCCTGATTCAGCCGACCTGCGCGCCGACCAACGACAACCTGATGGAACTGGTGGTGATGGCCGATGCCTTCCGCCGCTCCTCGGCCACTCGTATCACCGCTGTCATCCCCTACTTCGGCTATGCCCGCCAGGATCGCCGTCCGCGTTCCGCCCGCGTGGCCATCAGCGCCAAGGTAGTGGCCGACATGCTGACCGTCGTCGGGGTCAACCGTGTCCTCACGGTCGACCTGCACGCGGATCAGATCCAGGGCTTCTTCGATATCCCGGTAGACAACATCTACGGTTCGCCCGTGCTGGTGGACGATATCGAAGACCAGCGCTTCGAGAACCTGATGATCGTCTCCCCGGACATCGGCGGCGTGGTGCGCGCGCGCGCCGTGGCCAAGTCCCTGGGCGTGGATCTTGCGATCATCGACAAGCGTCGTCCCAAGGCCAACCAGTCCGAAGTGATGCACATCATCGGTGACGTCGAAGGCCGTACCTGCGTACTGGTAGACGACATGGTCGATACCGCCGGCACCCTCGGTCACGCCGCCAAGGCCCTGAAAGAGCACGGCGCCGCCAAGGTCATCGCCTACTGCACCCACCCGGTGCTGTCCGGCCGTGCCATCGAGAACATCGAGAAATCCGTACTGGACGAGCTGGTGGTGACCAACACCATCCCGCTGTCCGCCGCTGCCCAGGCCTGTGGCCGCATCCGCCAGCTGGACATCGCTCCGGTCGTTGCGGAAGCCATGCGCCGGATCAGCAACGAAGAATCGATCAGCGCGATGTTCCGCTGA
Protein Properties
Protein Residues: 313
Protein Molecular Weight: 34 kDa
Protein Theoretical pI: 6.52
Hydropathicity (GRAVY score): 0.097
Charge at pH 7 (predicted): -1.67
Protein Sequence: 
>PA4670
MSKMMVFTGNANPDLARRVVRQLHIPLGDVSVGKFSDGEISVEINENVRGKDVFLIQPTCAPTNDNLMELVVMADAFRRSSATRITAVIPYFGYARQDRRPRSARVAISAKVVADMLTVVGVNRVLTVDLHADQIQGFFDIPVDNIYGSPVLVDDIEDQRFENLMIVSPDIGGVVRARAVAKSLGVDLAIIDKRRPKANQSEVMHIIGDVEGRTCVLVDDMVDTAGTLGHAAKALKEHGAAKVIAYCTHPVLSGRAIENIEKSVLDELVVTNTIPLSAAAQACGRIRQLDIAPVVAEAMRRISNEESISAMFR
References
External Links:
Resource Link
Genome ID: PA4670
Entrez Gene ID: 881387
NCBI Protein ID: 15599865
General Reference: PaperBLAST - Find papers about PA4670 and its homologs