| Identification |
| Name: |
RNA 3'-terminal phosphate cyclase |
| Synonyms: |
- RNA cyclase
- RNA-3'-phosphate cyclase
|
| Gene Name: |
rtcA |
| Enzyme Class: |
|
| Biological Properties |
| General Function: |
Involved in RNA processing |
| Specific Function: |
Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps:(A) adenylation of the enzyme by ATP; (B) the enzyme acts on RNA-N3'P to produce RNA-N3'PP5'A; (C) a non catalytic nucleophilic attack by the adjacent 2'hydroxyl on the phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing |
| Cellular Location: |
Cytoplasm |
| KEGG Pathways: |
Not Available |
| KEGG Reactions: |
|
 | + | RNA 3'-terminal-phosphate | ↔ |  | + |  | + | RNA terminal-2',3'-cyclic-phosphate |
| |
|
| SMPDB Reactions: |
Not Available |
| PseudoCyc/BioCyc Reactions: |
|
| Complex Reactions: |
|
| + | RNA 3'-terminal-phosphate | → | | + | | + | RNA terminal-2',3'-cyclic-phosphate |
| |
|
| Transports: |
Not Available |
| Metabolites: |
|
| GO Classification: |
| Component |
|---|
| cell part | | cytoplasm | | intracellular part | | Function |
|---|
| catalytic activity | | cyclase activity | | ligase activity | | ligase activity, forming phosphoric ester bonds | | RNA-3'-phosphate cyclase activity | | Process |
|---|
| cellular macromolecule metabolic process | | macromolecule metabolic process | | metabolic process | | RNA metabolic process | | RNA processing |
|
| Gene Properties |
| Locus tag: |
PA4585 |
| Strand: |
+ |
| Entrez Gene ID: |
881010 |
| Accession: |
NP_253275.1 |
| GI: |
15599781 |
| Sequence start: |
5134689 |
| Sequence End: |
5135714 |
| Sequence Length: |
1025 |
| Gene Sequence: |
>PA4585
ATGAGAAAGGACCTCATCGAACTCGACGGCAGCGAAGGCGGCGGGCAGATCCTGCGTAGCGCCCTGAGCCTGTCGATGACCAGCGGCCAGCCGCTGCGCATCCGCAACATCCGTGGCCGGCGCAGCCGTCCGGGGCTGCTGCGGCAGCACCTCACCGCGGTGCGCGCGGCGGCGGAAATCTGCGCGGCCGAGGTCGAGGGTGCCGAGCTCGGCTCACGCGAGCTGGCGTTCCGGCCCGGTGCGATCCGCGCCGGCGACTACGCCTTCGCCATCGGCTCCGCCGGCAGTTGCTCGCTGGTACTGCAAACCCTGCTGCCGGCGCTGCTCGCGGCCAACGGCGAAAGCCGGGTGAGGATCAGCGGCGGCACCCACAATCCACTGGCGCCGCCGGCGGACTTTCTCCGCGACAGCTGGCTGCCGCTGTTGCAGCGGATGGGCGCGGAAGTCGACCTGGAACTGCTGCGCCACGGCTTCGTACCCGCCGGCGGTGGCGAGCTGCTGGCGCGGGTACGCCCGGCACGCTGGCGGCCGCTGCAACTGGAGCATCCCGGCGCGGCGCTGCGGCGCCAGGCGCGGGCGCTGCTCGCCGGGATTCCCGGGCACGTCGGCGAGCGTGAGCTGGAGAGGGTCCGCCAGCGCCTCGGTTGGAGCGACGAAGAACGCCAGCTGGAGTTCCTCGCGGAGGACCAGGGGCCGGGCAACGCCCTGCTGCTGCGGATCGACTGCGAGCACATCTGCGCGACCTTCTGCGCCTTCGGCCAGGCCGGCGTCAGCGCCGAACGGGTGGCGGAACAGGTCGCGACGCAAGCCATCGGCTGGATGGAAAGCGGCTGCGCGGCGGACGAGCACCTCGCCGACCAATTGCTGCTGCCCATGGCCCTGGCCGGCGCCGGCAGCTTCACCACGCCGCGGCTGAGCGCCCATCTGCAAAGCAACCGCCGGGTTATCGAACGCTTCCTGCCGGTGAGGATCGGCGACCAGGCGCTGGACGGCGGCGGTCATCGCATCGTCATCACATCGGCTTGA |
| Protein Properties |
| Protein Residues: |
341 |
| Protein Molecular Weight: |
36.6 kDa |
| Protein Theoretical pI: |
7.89 |
| Hydropathicity (GRAVY score): |
-0.088 |
| Charge at pH 7 (predicted): |
2.99 |
| Protein Sequence: |
>PA4585
MRKDLIELDGSEGGGQILRSALSLSMTSGQPLRIRNIRGRRSRPGLLRQHLTAVRAAAEICAAEVEGAELGSRELAFRPGAIRAGDYAFAIGSAGSCSLVLQTLLPALLAANGESRVRISGGTHNPLAPPADFLRDSWLPLLQRMGAEVDLELLRHGFVPAGGGELLARVRPARWRPLQLEHPGAALRRQARALLAGIPGHVGERELERVRQRLGWSDEERQLEFLAEDQGPGNALLLRIDCEHICATFCAFGQAGVSAERVAEQVATQAIGWMESGCAADEHLADQLLLPMALAGAGSFTTPRLSAHLQSNRRVIERFLPVRIGDQALDGGGHRIVITSA |
| References |
| External Links: |
|
| General Reference: |
PaperBLAST - Find papers about PA4585 and its homologs
|
