Nicotinate-nucleotide adenylyltransferase (PA4006)

Identification
Name: Nicotinate-nucleotide adenylyltransferase
Synonyms:
  • Deamido-NAD(+) diphosphorylase
  • Deamido-NAD(+) pyrophosphorylase
  • Nicotinate mononucleotide adenylyltransferase
  • NaMN adenylyltransferase
Gene Name: nadD
Enzyme Class:
Biological Properties
General Function: Involved in catalytic activity
Specific Function: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Cellular Location: Not Available
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb+Thumb+Thumb ↔ Thumb+Thumb
Adenosine triphosphate + Hydrogen ion + Nicotinamide ribotide + NMN ↔ NAD + Pyrophosphate
ReactionCard
Thumb+Thumb+Thumb ↔ Thumb+Thumb
Adenosine triphosphate + Hydrogen ion + Nicotinamide ribotide ↔ Nicotinic acid adenine dinucleotide + Pyrophosphate
ReactionCard
Thumb+Thumb ↔ Thumb+Thumb
Adenosine triphosphate + Nicotinamide ribotide ↔ Pyrophosphate + NAD
ReactionCard
Thumb+Thumb ↔ Thumb+Thumb
Adenosine triphosphate + Nicotinamide ribotide ↔ Pyrophosphate + Nicotinic acid adenine dinucleotide
ReactionCard
SMPDB Reactions:
nicotinate beta-D-ribonucleotide+Thumb+Thumb+Thumb → Pyrophosphate+Thumb
nicotinate beta-D-ribonucleotide + Adenosine triphosphate + Hydrogen ion + Nicotinamide ribotide → Pyrophosphate + Nicotinic acid adenine dinucleotide
ReactionCard
nicotinate beta-D-ribonucleotide+Thumb+Thumb+Thumb → Pyrophosphate+Thumb
nicotinate beta-D-ribonucleotide + Adenosine triphosphate + Hydrogen ion + Nicotinamide ribotide → Pyrophosphate + Nicotinic acid adenine dinucleotide
ReactionCard
PseudoCyc/BioCyc Reactions:
Thumb+Thumb+Thumb+Thumb ↔ Thumb+Thumb
Adenosine triphosphate + Hydrogen ion + Nicotinamide ribotide + NMN ↔ NAD + Pyrophosphate
ReactionCard
Thumb+Thumb+Thumb ↔ Thumb+Thumb
Adenosine triphosphate + Hydrogen ion + Nicotinamide ribotide ↔ Nicotinic acid adenine dinucleotide + Pyrophosphate
ReactionCard
Thumb+Thumb ↔ Thumb+Thumb
Adenosine triphosphate + Nicotinamide ribotide ↔ Pyrophosphate + NAD
ReactionCard
Thumb+Thumb+Thumb → Thumb+Thumb
Hydrogen ion + Adenosine triphosphate + Nicotinamide ribotide → Pyrophosphate + Nicotinic acid adenine dinucleotide
ReactionCard
Complex Reactions:
Thumb+Thumb → Thumb+Thumb
Adenosine triphosphate + Nicotinamide ribotide → Pyrophosphate + Nicotinic acid adenine dinucleotide
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB000148Adenosine triphosphateMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB000197NADMetaboCard
PAMDB000095Nicotinamide ribotideMetaboCard
PAMDB000286Nicotinic acid adenine dinucleotideMetaboCard
PAMDB003612NMNMetaboCard
PAMDB000633PyrophosphateMetaboCard
GO Classification:
Function
catalytic activity
nucleotidyltransferase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
Process
biosynthetic process
cellular metabolic process
coenzyme biosynthetic process
coenzyme metabolic process
cofactor metabolic process
metabolic process
NAD biosynthetic process
nicotinamide nucleotide biosynthetic process
pyridine nucleotide biosynthetic process
Gene Properties
Locus tag: PA4006
Strand: -
Entrez Gene ID: 878969
Accession: NP_252695.1
GI: 15599201
Sequence start: 4486203
Sequence End: 4486847
Sequence Length: 644
Gene Sequence: 
>PA4006
ATGGGCAAACGTATCGGCCTGTTCGGCGGCACTTTCGACCCCGTGCATATCGGACATATGCGCAGCGCCGTGGAAATGGCCGAGCAGTTCGCCCTCGACGAACTGCGCCTGCTGCCCAATGCGCGGCCGCCGCACCGGGAAACCCCGCAGGTGTCGGCCGCGCAGCGGTTGGCGATGGTCGAGCGGGCGGTGGCGGGAGTCGAGCGATTGACGGTCGATCCCCGCGAACTGCAGCGCGACAAGCCGTCCTACACCATCGACACCCTGGAGTCGGTGCGGGCGGAACTGGCGGCCGACGACCAGTTGTTCATGCTGATCGGCTGGGATGCCTTCTGCGGCTTGCCGACGTGGCACCGCTGGGAGGCGTTGCTGGATCACTGCCACATCGTCGTGTTGCAGCGTCCGGATGCCGACAGCGAGCCGCCGGAGTCGCTGCGCGACCTGCTGGCGGCGCGGAGCGTGGCCGACCCGCAGGCCCTGAAAGGGCCGGGCGGACAGATCACCTTCGTCTGGCAGACGCCGCTGGCGGTGTCCGCCACCCAGATCCGCGCGCTGCTGGGTGCCGGGCGCTCCGTGCGTTTCCTGGTGCCGGACGCGGTATTGAACTACATCGAGGCGCACCACCTGTATCGTGCGCCACACTGA
Protein Properties
Protein Residues: 214
Protein Molecular Weight: 23.8 kDa
Protein Theoretical pI: 6.42
Hydropathicity (GRAVY score): -0.147
Charge at pH 7 (predicted): -2.9
Protein Sequence: 
>PA4006
MGKRIGLFGGTFDPVHIGHMRSAVEMAEQFALDELRLLPNARPPHRETPQVSAAQRLAMVERAVAGVERLTVDPRELQRDKPSYTIDTLESVRAELAADDQLFMLIGWDAFCGLPTWHRWEALLDHCHIVVLQRPDADSEPPESLRDLLAARSVADPQALKGPGGQITFVWQTPLAVSATQIRALLGAGRSVRFLVPDAVLNYIEAHHLYRAPH
References
External Links:
Resource Link
Genome ID: PA4006
Entrez Gene ID: 878969
NCBI Protein ID: 15599201
General Reference: PaperBLAST - Find papers about PA4006 and its homologs