Seryl-tRNA synthetase (PA2612)

Identification
Name: Seryl-tRNA synthetase
Synonyms:
  • Serine--tRNA ligase
  • SerRS
  • Seryl-tRNA(Ser/Sec) synthetase
Gene Name: serS
Enzyme Class:
Biological Properties
General Function: Involved in nucleotide binding
Specific Function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Cellular Location: Cytoplasm
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb+tRNA(Ser)+tRNA(Ser) ↔ Thumb+Thumb+L-Seryl-tRNA(Ser)+L-Seryl-tRNA(Ser)
Adenosine triphosphate + L-Serine + tRNA(Ser) + tRNA(Ser) ↔ Adenosine monophosphate + Pyrophosphate + L-Seryl-tRNA(Ser) + L-Seryl-tRNA(Ser)
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Thumb+Thumb+tRNA(Ser) ↔ Thumb+Thumb+L-Seryl-tRNA(Ser)
Adenosine triphosphate + L-Serine + tRNA(Ser) ↔ Adenosine monophosphate + Pyrophosphate + L-Seryl-tRNA(Ser)
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Thumb+Thumb+tRNA(Sec) ↔ Thumb+Thumb+L-Seryl-tRNA(Sec)
Adenosine triphosphate + L-Serine + tRNA(Sec) ↔ Adenosine monophosphate + Pyrophosphate + L-Seryl-tRNA(Sec)
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SMPDB Reactions:
L-Serine+Thumb+Thumb+tRNA(Ser)+Thumb → Thumb+Pyrophosphate+L-Seryl-tRNA(Ser)
L-Serine + Adenosine triphosphate + Hydrogen ion + tRNA(Ser) + L-Serine → Adenosine monophosphate + Pyrophosphate + L-Seryl-tRNA(Ser)
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PseudoCyc/BioCyc Reactions:
Thumb+Thumb+tRNA(SeCys) → Thumb+Thumb
Adenosine triphosphate + L-Serine + tRNA(SeCys) → Adenosine monophosphate + Pyrophosphate
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Thumb+Thumb+tRNA(Ser)+tRNA(Ser) ↔ Thumb+Thumb+L-Seryl-tRNA(Ser)+L-Seryl-tRNA(Ser)
Adenosine triphosphate + L-Serine + tRNA(Ser) + tRNA(Ser) ↔ Adenosine monophosphate + Pyrophosphate + L-Seryl-tRNA(Ser) + L-Seryl-tRNA(Ser)
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Thumb+Thumb+tRNA(Ser) ↔ Thumb+Thumb+L-Seryl-tRNA(Ser)
Adenosine triphosphate + L-Serine + tRNA(Ser) ↔ Adenosine monophosphate + Pyrophosphate + L-Seryl-tRNA(Ser)
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Thumb+Thumb+tRNA(Sec) ↔ Thumb+Thumb+L-Seryl-tRNA(Sec)
Adenosine triphosphate + L-Serine + tRNA(Sec) ↔ Adenosine monophosphate + Pyrophosphate + L-Seryl-tRNA(Sec)
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Thumb+Thumb+tRNA(Ser) → Thumb+Thumb+L-seryl-tRNA(Ser)
Adenosine triphosphate + L-Serine + tRNA(Ser) → Adenosine monophosphate + Pyrophosphate + L-seryl-tRNA(Ser)
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Thumb+Thumb+tRNA(Sec) → Thumb+Thumb+L-seryl-tRNA(Sec)
Adenosine triphosphate + L-Serine + tRNA(Sec) → Adenosine monophosphate + Pyrophosphate + L-seryl-tRNA(Sec)
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L-Serine+Thumb+Thumb+tRNA(Ser)+Thumb → Thumb+Pyrophosphate+L-Seryl-tRNA(Ser)
L-Serine + Adenosine triphosphate + Hydrogen ion + tRNA(Ser) + L-Serine → Adenosine monophosphate + Pyrophosphate + L-Seryl-tRNA(Ser)
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Thumb
a tRNAser + L-serine + ATP + H+ → an L-seryl-[tRNAser] + AMP + diphosphate
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PAMDB001633+PAMDB000077+PAMDB110477 → PAMDB110246+PAMDB110478
Hydrogen ion + L-Serine + ATP → diphosphate + AMP
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Complex Reactions:
Thumb+Thumb+tRNA(SeCys) → Thumb+Thumb
Adenosine triphosphate + L-Serine + tRNA(SeCys) → Adenosine monophosphate + Pyrophosphate
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Thumb+Thumb+tRNA(Ser) → Thumb+Thumb+L-seryl-tRNA(Ser)
Adenosine triphosphate + L-Serine + tRNA(Ser) → Adenosine monophosphate + Pyrophosphate + L-seryl-tRNA(Ser)
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Thumb+Thumb+tRNA(Sec) → Thumb+Thumb+L-seryl-tRNA(Sec)
Adenosine triphosphate + L-Serine + tRNA(Sec) → Adenosine monophosphate + Pyrophosphate + L-seryl-tRNA(Sec)
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB000014Adenosine monophosphateMetaboCard
PAMDB000148Adenosine triphosphateMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB000077L-SerineMetaboCard
PAMDB000633PyrophosphateMetaboCard
GO Classification:
Component
cell part
cytoplasm
intracellular part
Function
adenyl nucleotide binding
adenyl ribonucleotide binding
aminoacyl-tRNA ligase activity
ATP binding
binding
catalytic activity
ligase activity
ligase activity, forming aminoacyl-tRNA and related compounds
ligase activity, forming carbon-oxygen bonds
nucleoside binding
nucleotide binding
purine nucleoside binding
serine-tRNA ligase activity
Process
biosynthetic process
cellular macromolecule biosynthetic process
cellular macromolecule metabolic process
macromolecule biosynthetic process
macromolecule metabolic process
metabolic process
ncRNA metabolic process
RNA metabolic process
seryl-tRNA aminoacylation
translation
tRNA aminoacylation
tRNA aminoacylation for protein translation
tRNA metabolic process
Gene Properties
Locus tag: PA2612
Strand: -
Entrez Gene ID: 882318
Accession: NP_251302.1
GI: 15597808
Sequence start: 2953416
Sequence End: 2954696
Sequence Length: 1280
Gene Sequence: 
>PA2612
ATGCTCGATCCCAAACTGGTACGCACCCAGCCGCAAGAAGTGGCTGCCCGCCTGGCCACCCGTGGCTTCCAACTGGATGTCGCACGCATCGAAGCGCTGGAAGAGCAGCGCAAGTCGGTACAGACCCGTACCGAGCAGCTGCAAGCCGAGCGCAACGCGCGTTCCAAGGCGATCGGCCAGGCCAAGCAGCGTGGCGAGGACATCGCGCCGCTGCTGGCCGATGTCGACCGCATGGGCTCCGAGCTGGAGGAAGGCAAGCGCCAGCTGGACGCCATCCAGGGCGAACTGGATGCCATGCTGCTGGGCATTCCCAACCTGCCACACGAGTCGGTGCCGGTCGGTGCCGACGAGGACGCCAACGTCGAAGTGCGTCGCTGGGGCACGCCGAAGACCTTCGATTTCGAGGTCAAGGACCATGTCGCCCTCGGTGAACGGCACGGCTGGCTGGATTTCGAGACCGCTGCCAAGCTTTCCGGCGCGCGCTTCGCCCTCATGCGCGGCCCGATCGCCCGCCTGCATCGCGCCCTGGCGCAGTTCATGATCAACCTGCATACCGCCGAGCATGGCTACGAGGAGGCCTACACCCCCTATCTCGTCCAGGCTCCGGCGCTGCAAGGCACCGGCCAGTTGCCGAAGTTCGAGGAGGACCTGTTCAAGATCGGCCGCGACGGCGAAGCCGACCTCTACCTGATCCCGACCGCCGAGGTTTCGCTGACCAACATCGTCTCCGGGCAGATCCTCGACGCCAAGCAGTTGCCGCTGAAGTTCGTCGCCCATACCCCGTGCTTCCGCAGCGAGGCCGGTGCCTCCGGGCGCGATACCCGCGGGATGATCCGCCAGCACCAGTTCGACAAGGTGGAGATGGTGCAGATCGTCGATCCGGCCACCTCCTACGAAGCGCTGGAAGGCCTGACCGCCAACGCCGAGCGCGTCCTGCAACTGCTCGAGCTGCCGTATCGGGTGCTGGCGCTGTGCACCGGCGACATGGGCTTCGGTGCGACCAAGACCTACGACCTGGAAGTCTGGGTTCCCAGCCAGGACAAGTACCGCGAGATTTCCTCCTGCTCCAACTGCGGCGACTTCCAGGCCCGGCGCATGCAGGCCCGCTACCGCAATCCGGAAACCGGCAAGCCCGAGCTGGTGCACACCCTCAACGGCTCCGGCCTGGCCGTCGGCCGTACCCTGGTGGCGGTACTGGAGAACTACCAGCAGGCGGACGGCTCGATCCGTGTGCCGGAAGTCCTCAAGCCCTACATGGCTGGCATCGAGGTGATCGGCTGA
Protein Properties
Protein Residues: 426
Protein Molecular Weight: 47.2 kDa
Protein Theoretical pI: 5.25
Hydropathicity (GRAVY score): -0.356
Charge at pH 7 (predicted): -9.93
Protein Sequence: 
>PA2612
MLDPKLVRTQPQEVAARLATRGFQLDVARIEALEEQRKSVQTRTEQLQAERNARSKAIGQAKQRGEDIAPLLADVDRMGSELEEGKRQLDAIQGELDAMLLGIPNLPHESVPVGADEDANVEVRRWGTPKTFDFEVKDHVALGERHGWLDFETAAKLSGARFALMRGPIARLHRALAQFMINLHTAEHGYEEAYTPYLVQAPALQGTGQLPKFEEDLFKIGRDGEADLYLIPTAEVSLTNIVSGQILDAKQLPLKFVAHTPCFRSEAGASGRDTRGMIRQHQFDKVEMVQIVDPATSYEALEGLTANAERVLQLLELPYRVLALCTGDMGFGATKTYDLEVWVPSQDKYREISSCSNCGDFQARRMQARYRNPETGKPELVHTLNGSGLAVGRTLVAVLENYQQADGSIRVPEVLKPYMAGIEVIG
References
External Links:
Resource Link
Genome ID: PA2612
Entrez Gene ID: 882318
NCBI Protein ID: 15597808
General Reference: PaperBLAST - Find papers about PA2612 and its homologs