| Identification |
| Name: |
Leucyl-tRNA synthetase |
| Synonyms: |
- Leucine--tRNA ligase
- LeuRS
|
| Gene Name: |
leuS |
| Enzyme Class: |
|
| Biological Properties |
| General Function: |
Involved in nucleotide binding |
| Specific Function: |
ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu) |
| Cellular Location: |
Cytoplasm |
| KEGG Pathways: |
- Aminoacyl-tRNA biosynthesis pae00970
- Valine, leucine and isoleucine biosynthesis pae00290
|
| KEGG Reactions: |
|
 | + |  | + | tRNA(Leu) | + | tRNA(Leu) | ↔ |  | + |  | + | L-Leucyl-tRNA | + | L-Leucyl-tRNA |
| |
|
| SMPDB Reactions: |
|
| + | | + |  | + | tRNA(Leu) | → | | + | Pyrophosphate | + | L-Leucyl-tRNA(Leu) |
| |
|
| PseudoCyc/BioCyc Reactions: |
|
| Complex Reactions: |
|
| + | | + | tRNA(Leu) | → | | + | L-Leucyl-tRNA(Leu) | + | |
| | |
| + | | + | tRNA(Leu) | → | | + | | + | L-leucyl-tRNA(Leu) |
| |
|
| Transports: |
Not Available |
| Metabolites: |
|
| GO Classification: |
| Component |
|---|
| cell part | | cytoplasm | | intracellular part | | Function |
|---|
| adenyl nucleotide binding | | adenyl ribonucleotide binding | | aminoacyl-tRNA ligase activity | | ATP binding | | binding | | catalytic activity | | leucine-tRNA ligase activity | | ligase activity | | ligase activity, forming aminoacyl-tRNA and related compounds | | ligase activity, forming carbon-oxygen bonds | | nucleoside binding | | nucleotide binding | | purine nucleoside binding | | Process |
|---|
| biosynthetic process | | cellular macromolecule biosynthetic process | | cellular macromolecule metabolic process | | leucyl-tRNA aminoacylation | | macromolecule biosynthetic process | | macromolecule metabolic process | | metabolic process | | ncRNA metabolic process | | RNA metabolic process | | translation | | tRNA aminoacylation | | tRNA aminoacylation for protein translation | | tRNA metabolic process |
|
| Gene Properties |
| Locus tag: |
PA3987 |
| Strand: |
+ |
| Entrez Gene ID: |
878925 |
| Accession: |
NP_252676.1 |
| GI: |
15599182 |
| Sequence start: |
4466925 |
| Sequence End: |
4469546 |
| Sequence Length: |
2621 |
| Gene Sequence: |
>PA3987
ATGCACGAGCAATATCAGCCACTCGAGATCGAAACCCAGGCCCAGAACTACTGGAAAGAACACCAGTCCTTCCTCGTCAGGGAGCTACCCGACAAGGAGAAGTTCTACTGCCTGTCGATGTTCCCGTATCCGAGCGGCAAGCTGCACATGGGCCACGTGCGCAACTACACCATCGGCGACGTGATCAGCCGCTACCACCGCATGCAGGGCCGCAACGTGCTGCAGCCGATGGGCTGGGACGCGTTCGGCATGCCGGCGGAAAACGCCGCGATGAAGAACAACGTCGCCCCGGCGGCCTGGACCTACGACAACATCGCCTACATGAAGTCGCAGCTGGACAGCCTCGGCCTGGCGATCGACTGGAGCCGCGAGGTCACCACCTGCAAGCCGGACTACTACCGCTGGGAGCAGTGGCTGTTCACCCGCCTGTTCGAAAAAGGGGTGATCTACCGCAAGAACGGCACGGTCAATTGGGATCCGGTCGACCAGACCGTACTCGCCAACGAGCAGGTGATCGACGGGCGCGGCTGGCGCTCCGGCGCGCTGATCGAGAAGCGCGAGATCCCGATGTACTACTTCAAGATCACCGCCTACGCCGAGGAACTGCTGGAGAGCCTCGACAACCTGCCCGGCTGGCCGGAGCAGGTGAAGACCATGCAGCGCAACTGGATCGGCAAGTCGCGCGGGATGGAGATCGGCTTCCCCTACGACCAGGCCTCCATCGGCCACGCCGGCCAACTGAAGGTGTTCACCACCCGTCCGGACACCCTGATGGGCGCCACCTACGTCGCCGTCGCCGCCGAACACCCGCTGGCCACCCAGGCAGCGCAGAACGACCCGCAGTTGCAGGCGTTCATCGACGAATGCAAGCGCGGCGGCGTCGCCGAGGCCGACATCGCCACCCAGGAGAAGAAAGGCATGGCCACTTCCCTGTTCGTCGAACACCCGCTGACCGGCGACAAGCTGCCGGTATGGGTCGCCAACTACGTGCTGATGAACTACGGCGAAGGCGCGGTGATGGCGGTGCCCGGCCATGACGAGCGCGACTTCGAGTTCGCCAACAAGTACGGCCTGCCGATCCGCCAGGTGATCGCCAAGGTCGAGGGCGACAACGACTTCGAGTCCAGCGTCTGGAAGGAGTGGTACGGCGCCAAGGACGAGTCCGTGCTCACCGTCAACTCCGGCAAGTACGACAACCTCGGCTACCAGGCCGCCTTCGACGCCATCGGCGCCGACCTCGAGGCCAAGGGCCTGGGCCAGGCGCGCACCCAGTTCCGCCTGCGCGACTGGGGCATCAGCCGCCAGCGCTACTGGGGCTGCCCGATCCCGATCATCCACTGCGAGGCTTGCGGCGACGTCCCGGTGCCGGCCGACCAGTTGCCGGTGGTGCTGCCGGAAGACGTGGTACCGGACGGCTCCGGTTCGCCGCTGGCGAAGATGCCGGAATTCTACGAATGCAACTGCCCGAAATGCGGCCAGCCGGCCAAGCGCGAAACCGACACCATGGACACCTTCGTCGAGTCGTCCTGGTATTTCGCCCGCTACGCCTGCCCGCAGTTCGAAGGCGGCATGCTGGACAGGAAGGCGGCCGACTACTGGCTGCCGGTCGACCAGTACATCGGCGGCATCGAGCACGCCATCCTGCACCTGCTCTATGCGCGCTTCTTCCACAAGCTGATGCGCGACGAAGGCCTGGTCGGCAGCGACGAACCGTTCAAGAACCTGCTGACCCAGGGCATGGTGGTCGCCGATACCTACTACCGGACCACCGCCAACGGCGGCAAGGACTGGTTCAACCCGGCCGACGTCGAGGTCGAGCGTGACGCCAAGGCCAAGGTCGTCGGCGCGCGCCTGAAGAGCGACGGCCAGCCGGTCGAGATCGGCGGCACCGAGAAGATGTCGAAGTCGAAGAACAACGGTGTCGACCCGCAATCGATGATCGACCAGTACGGTGCCGATACCTGCCGCCTGTTCATGATGTTCGCCTCGCCGCCGGACATGAGCCTGGAGTGGTCGGACGCCGGCGTCGAGGGCGCCAACCGCTTCCTCCGCCGCGTCTGGCGCCTGGCTCACGCCCACGTCAGCGCCGGCCTCCCCGGCGCGCTGGACGTCGCCGCCCTGAGCGACGCGCAGAAGCAGGTCCGCCGCGCCATCCACCTGGCGATCAGGCAGGCCAGCCAGGATGTCGGCCAGCACCACAAGTTCAACACCGCCATCGCCGCGGTGATGACCCTGATGAACGTGCTGGAGAAGGCGCCGAACCAGGACGCCCAGGACCGCGCCCTGATCCAGGAAGGCTTGGAAACCGTGGTCCTGCTGCTGGCGCCCATCACTCCGCACATCTGCCACGTGCTCTGGGGCCAGCTCGGCCATGCCGAAGCGGTGATCGATGCGCGCTGGCCGAGCGTCGACGAGAGCGCACTGGTGCAGGACACCCTGCAACTGGTGGTGCAGGTCAACGGCAAGCTGCGCGGACACATCGACGTGGCCGCCAGCGCCAGCCGCGAGGATGTCGAGGCCGCCGCGCGCGCCAACGAGAACGTGCTGCGTTTCACCGAAGGCCTGAGCATCCGCAAGGTCATCGTGGTACCGGGCAAACTGGTCAACATCGTCGCCAACTGA |
| Protein Properties |
| Protein Residues: |
873 |
| Protein Molecular Weight: |
97.6 kDa |
| Protein Theoretical pI: |
5.46 |
| Hydropathicity (GRAVY score): |
-0.332 |
| Charge at pH 7 (predicted): |
-19.02 |
| Protein Sequence: |
>PA3987
MHEQYQPLEIETQAQNYWKEHQSFLVRELPDKEKFYCLSMFPYPSGKLHMGHVRNYTIGDVISRYHRMQGRNVLQPMGWDAFGMPAENAAMKNNVAPAAWTYDNIAYMKSQLDSLGLAIDWSREVTTCKPDYYRWEQWLFTRLFEKGVIYRKNGTVNWDPVDQTVLANEQVIDGRGWRSGALIEKREIPMYYFKITAYAEELLESLDNLPGWPEQVKTMQRNWIGKSRGMEIGFPYDQASIGHAGQLKVFTTRPDTLMGATYVAVAAEHPLATQAAQNDPQLQAFIDECKRGGVAEADIATQEKKGMATSLFVEHPLTGDKLPVWVANYVLMNYGEGAVMAVPGHDERDFEFANKYGLPIRQVIAKVEGDNDFESSVWKEWYGAKDESVLTVNSGKYDNLGYQAAFDAIGADLEAKGLGQARTQFRLRDWGISRQRYWGCPIPIIHCEACGDVPVPADQLPVVLPEDVVPDGSGSPLAKMPEFYECNCPKCGQPAKRETDTMDTFVESSWYFARYACPQFEGGMLDRKAADYWLPVDQYIGGIEHAILHLLYARFFHKLMRDEGLVGSDEPFKNLLTQGMVVADTYYRTTANGGKDWFNPADVEVERDAKAKVVGARLKSDGQPVEIGGTEKMSKSKNNGVDPQSMIDQYGADTCRLFMMFASPPDMSLEWSDAGVEGANRFLRRVWRLAHAHVSAGLPGALDVAALSDAQKQVRRAIHLAIRQASQDVGQHHKFNTAIAAVMTLMNVLEKAPNQDAQDRALIQEGLETVVLLLAPITPHICHVLWGQLGHAEAVIDARWPSVDESALVQDTLQLVVQVNGKLRGHIDVAASASREDVEAAARANENVLRFTEGLSIRKVIVVPGKLVNIVAN |
| References |
| External Links: |
|
| General Reference: |
PaperBLAST - Find papers about PA3987 and its homologs
|
