| Identification |
| Name: |
Methionyl-tRNA synthetase |
| Synonyms: |
- Methionine--tRNA ligase
- MetRS
|
| Gene Name: |
metG |
| Enzyme Class: |
|
| Biological Properties |
| General Function: |
Involved in nucleotide binding |
| Specific Function: |
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation |
| Cellular Location: |
Cytoplasm |
| KEGG Pathways: |
|
| KEGG Reactions: |
|
 | + |  | + | tRNA(Met) | + | tRNA(Met) | ↔ |  | + |  | + | L-Methionyl-tRNA | + | L-Methionyl-tRNA |
| |
|
| SMPDB Reactions: |
|
| + | | + |  | + | tRNA(Met) | → | | + | Pyrophosphate | + | L-methionyl-tRNA(Met) |
| |
|
| PseudoCyc/BioCyc Reactions: |
|
| Complex Reactions: |
|
| + | | + | tRNA(Met) | → | | + | L-Methionyl-tRNA (Met) | + | |
| | |
| + | | + | tRNA(Met) | → | | + | | + | L-methionyl-tRNA(Met) |
| |
|
| Transports: |
Not Available |
| Metabolites: |
|
| GO Classification: |
| Component |
|---|
| cell part | | cytoplasm | | intracellular part | | Function |
|---|
| adenyl nucleotide binding | | adenyl ribonucleotide binding | | aminoacyl-tRNA ligase activity | | ATP binding | | binding | | catalytic activity | | ligase activity | | ligase activity, forming aminoacyl-tRNA and related compounds | | ligase activity, forming carbon-oxygen bonds | | methionine-tRNA ligase activity | | nucleic acid binding | | nucleoside binding | | nucleotide binding | | purine nucleoside binding | | RNA binding | | tRNA binding | | Process |
|---|
| biosynthetic process | | cellular macromolecule biosynthetic process | | cellular macromolecule metabolic process | | macromolecule biosynthetic process | | macromolecule metabolic process | | metabolic process | | methionyl-tRNA aminoacylation | | ncRNA metabolic process | | RNA metabolic process | | translation | | tRNA aminoacylation | | tRNA aminoacylation for protein translation | | tRNA metabolic process |
|
| Gene Properties |
| Locus tag: |
PA3482 |
| Strand: |
+ |
| Entrez Gene ID: |
878831 |
| Accession: |
NP_252172.1 |
| GI: |
15598678 |
| Sequence start: |
3895324 |
| Sequence End: |
3897357 |
| Sequence Length: |
2033 |
| Gene Sequence: |
>PA3482
ATGTCCGAACCACGCAAGATCCTCGTTACCAGCGCCCTCCCCTACGCCAACGGTTCCATTCACCTGGGACACATGCTGGAGTACATCCAGACGGACATGTGGGTGCGCTTCCAGAAGATGCGTGGCAACCAGGCCGTCTACGTCTGCGCCGACGACGCCCACGGTTCGGCGATCATGCTCCGCGCCGAGCGCGAGGGCATCACCTCCGAGCAACTGATCGACGCCGTGCGCGCCGAGCACATGGGCGACTTCGCCGACTTCCTGGTGGACTTCGACAACTACCACTCGACCCACTCGGAAGAGAACCGCGAGCTGTCCAGCGCGATCTACCTGAAACTGCGCGACGCCGGGCACATCGACACCCGCCCGGTGACCCAGTACTTCGACCCGGAAAAGCAGATGTTCCTCGCCGACCGCTTCATCAAGGGCACCTGCCCGAAGTGCGGCACCGCCGACCAGTACGGCGACAACTGCGAGGCCTGCGGCGCGACCTACGCCCCGACCGAACTGAAGGACCCGAAATCGGCGATCTCCGGCGCCACCCCGGTGCTCAAGGAATCGCTGCACTACTTCTTCAAGCTGCCGGACTTCGAGGCCATGCTCAAGCAATGGACCCGCAGCGGCGCCCTTCAGGAGTCGGTGGCCAACAAGCTCGCCGAATGGCTGGACAGCGGCCTCCAGCAGTGGGACATCTCGCGTGACGCGCCGTACTTCGGCTTCGAGATTCCCGACGCTCCCGGCAAGTACTTCTACGTCTGGCTGGACGCGCCGATCGGCTACATGGCCAGCTTCAAGAACCTCTGCGCGCGGCGTCCCGAGCTGGACTTCGACGCGTTCTGGGGCAAGGACTCCGGCGCCGAGCTGTACCACTTCATCGGCAAGGACATCGTCAACTTCCACGCGCTGTTCTGGCCGGCCATGCTCGAAGGCGCCGGCTACCGCAAGCCGACCGCGCTGAACGTGCACGGCTACCTGACCGTGAACGGCCAGAAGATGTCCAAGTCGCGCGGCACCTTCGTCAAGGCGCGCACCTACCTCGACCACCTGGACCCGGAATACCTGCGCTACTACTACGCGTCCAAGCTCGGCCGCGGCGTCGAGGACCTCGACCTGAACCTCGAGGACTTCGTGCAGAAGGTCAACTCCGACCTGGTCGGCAAGGTCGTCAACATCGCCAGCCGCTGCGCCGGCTTCATCCACAAGGGCAACGCCGGCGTGCTGGTCGGCGCCGATCCGGCGCCGGAACTGCTCGCCGCCTTCCGCGAGGCCGCACCGGGCATCGCCGAGGCCTATGAGGCCCGCGACTTCAATCGCGCCATGCGCGAGATCATGGCCCTCGCCGACCGCGCCAACGCCTGGATCGCCGAACAGGCGCCCTGGGCGCTGGCCAAGCAGGAAGGCCAGCAGGACAAGGTCCAGGCCGTCTGCGGCCTGGGCATCAACCTGTTCCGCCAGTTGGTGATCTTCCTCAAGCCGGTGCTGCCGAAGCTGGCCGCCGCCGCCGAAGCCTTCCTCAACGTCGCCCCGCTGACCTGGGCCGACCACCAGACCCTGCTGGCCAACCACCAGTTGAACCCGTTCCAGCCCCTGATGACCCGTATCGAGCCCGCGAAAGTAGAAGCCATGATCGAAGCCTCCAAGGAAGACCTCGCCGCCGCATCCCAACCCGCCGGCAACGGCGAGCTGGTCAAGGAACCCATCGCCGCGGAGATCGACTTCGACGCTTTCGCCGCGGTCGACCTGCGCATCGCCCTGATCGAGAAGTGCGAATTCGTCGAAGGCGCCGACAAGCTGCTGCGCCTGTCGCTGGACATCGGCGACGCGAAGCGTAACGTGTTCTCCGGGATCAAGAGCGCATATCCCGACCCGAGTGCCCTGGAAGGCCGCCTGACGCTCTATGTGGCCAACCTGGCGCCGCGCAAGATGAAGTTCGGGGTGTCCGAGGGCATGGTCCTGGCCGCCGGCCCGGGTGGCGAGGAGATCTACCTGCTGAGTCCGGACAGCGGCGCCAAGCCGGGCCAGCGCGTCAAGTAA |
| Protein Properties |
| Protein Residues: |
677 |
| Protein Molecular Weight: |
74.9 kDa |
| Protein Theoretical pI: |
5.35 |
| Hydropathicity (GRAVY score): |
-0.192 |
| Charge at pH 7 (predicted): |
-14.63 |
| Protein Sequence: |
>PA3482
MSEPRKILVTSALPYANGSIHLGHMLEYIQTDMWVRFQKMRGNQAVYVCADDAHGSAIMLRAEREGITSEQLIDAVRAEHMGDFADFLVDFDNYHSTHSEENRELSSAIYLKLRDAGHIDTRPVTQYFDPEKQMFLADRFIKGTCPKCGTADQYGDNCEACGATYAPTELKDPKSAISGATPVLKESLHYFFKLPDFEAMLKQWTRSGALQESVANKLAEWLDSGLQQWDISRDAPYFGFEIPDAPGKYFYVWLDAPIGYMASFKNLCARRPELDFDAFWGKDSGAELYHFIGKDIVNFHALFWPAMLEGAGYRKPTALNVHGYLTVNGQKMSKSRGTFVKARTYLDHLDPEYLRYYYASKLGRGVEDLDLNLEDFVQKVNSDLVGKVVNIASRCAGFIHKGNAGVLVGADPAPELLAAFREAAPGIAEAYEARDFNRAMREIMALADRANAWIAEQAPWALAKQEGQQDKVQAVCGLGINLFRQLVIFLKPVLPKLAAAAEAFLNVAPLTWADHQTLLANHQLNPFQPLMTRIEPAKVEAMIEASKEDLAAASQPAGNGELVKEPIAAEIDFDAFAAVDLRIALIEKCEFVEGADKLLRLSLDIGDAKRNVFSGIKSAYPDPSALEGRLTLYVANLAPRKMKFGVSEGMVLAAGPGGEEIYLLSPDSGAKPGQRVK |
| References |
| External Links: |
|
| General Reference: |
PaperBLAST - Find papers about PA3482 and its homologs
|
