Identification
Name: Pantothenate synthetase
Synonyms:
  • PS
  • Pantoate--beta-alanine ligase
  • Pantoate-activating enzyme
Gene Name: panC
Enzyme Class:
Biological Properties
General Function: Involved in catalytic activity
Specific Function: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
Cellular Location: Cytoplasm (Potential)
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb+ThumbThumb+Thumb+Thumb+Thumb
Thumb+Thumb+ThumbThumb+Thumb+Thumb
SMPDB Reactions:
Thumb+Thumb+(R)-pantoate+ThumbThumb+Pyrophosphate+Thumb+Pantothenic acid+Thumb
Thumb+ThumbThumb+Pyrophosphate+Thumb
PseudoCyc/BioCyc Reactions:
Thumb+Thumb+ThumbThumb+Thumb+Thumb+Thumb
Thumb+Thumb+ThumbThumb+Thumb+Thumb
Complex Reactions: Not Available
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB000865(R)-PantoateMetaboCard
PAMDB000014Adenosine monophosphateMetaboCard
PAMDB000148Adenosine triphosphateMetaboCard
PAMDB000019beta-AlanineMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB000085Pantothenic acidMetaboCard
PAMDB000633PyrophosphateMetaboCard
GO Classification:
Function
acid-amino acid ligase activity
catalytic activity
ligase activity
ligase activity, forming carbon-nitrogen bonds
pantoate-beta-alanine ligase activity
Process
biosynthetic process
cellular metabolic process
coenzyme biosynthetic process
coenzyme metabolic process
cofactor metabolic process
metabolic process
pantothenate biosynthetic process
Gene Properties
Locus tag: PA4730
Strand: +
Entrez Gene ID: 881622
Accession: NP_253418.1
GI: 15599924
Sequence start: 5312261
Sequence End: 5313112
Sequence Length: 851
Gene Sequence:
>PA4730
ATGAACACCGTCAAGACCGTCCGTGAACTGCGCGCCGCGGTGGCGCGCGCCCGCAGCGAAGGCAAGCGCATCGGCTTCGTGCCGACCATGGGCAACCTCCACGCCGGCCATGCCGCGCTGGTAAAGAAAGCCGGCGAACGCGCCGACTTCGTGGTCGTCAGCATCTTCGTCAACCCGCTGCAATTCGGCCCCAGCGAAGACCTCGACACATACCCGCGAACCCTCGCAGCCGACCAGGAACGCCTGCTCGAAGCCGGCTGCCACCTGCTGTTCACCCCGACCGTCGAGGAAATGTACCCCGACGGCATGGACGGGCAGACCCGCATCCATGTTCCCGGCGTCTCCGAAGGTCTTTGCGGCGCCAGTCGTCCCGGCCATTTCGAAGGCGTGGCGACCGTGGTCAGCAAGCTGCTGAACATGGTCCAGCCGGACCTCGCGCTGTTCGGCGAAAAGGATTTCCAGCAGTTGGCGGTGATCCGCAAGCTGGTCCGCGACCTCAACCTGCCGGTGCAGATCTTCGGCGAGCCGACGGTGCGTGCCGCCGATGGCCTGGCGTTGTCCTCGCGCAACGGTTACCTCGACGAGCAGCAGCGCGCCGCCGCCCCGGCGATCTACCGCACCCTGCGGCAGCTCGGCGAACGCATCCGCGCCGGCGCCGAGGACTTCCCGGCATTGCTCGCCGACGCCCGCCAGGCCCTGGAACAGGCCGGGCTGCGCCCCGACTACCTGGAAATCCGCGAGCCGATCAGCCTGCGCCCCGGGGTACCCGGCGACCGCCAACTGGTGATCCTGGCCGCCGCCTACCTGGGCAGCACGCGGCTGATCGACAACCTCTCAGTCCACCTCGATTGA
Protein Properties
Protein Residues: 283
Protein Molecular Weight: 30.8 kDa
Protein Theoretical pI: 6.52
Hydropathicity (GRAVY score): -0.101
Charge at pH 7 (predicted): -1.61
Protein Sequence:
>PA4730
MNTVKTVRELRAAVARARSEGKRIGFVPTMGNLHAGHAALVKKAGERADFVVVSIFVNPLQFGPSEDLDTYPRTLAADQERLLEAGCHLLFTPTVEEMYPDGMDGQTRIHVPGVSEGLCGASRPGHFEGVATVVSKLLNMVQPDLALFGEKDFQQLAVIRKLVRDLNLPVQIFGEPTVRAADGLALSSRNGYLDEQQRAAAPAIYRTLRQLGERIRAGAEDFPALLADARQALEQAGLRPDYLEIREPISLRPGVPGDRQLVILAAAYLGSTRLIDNLSVHLD
References
External Links:
Resource Link
Genome ID: PA4730
Entrez Gene ID: 881622
NCBI Protein ID: 15599924
General Reference: PaperBLAST - Find papers about PA4730 and its homologs