| Identification |
| Name: |
Valyl-tRNA synthetase |
| Synonyms: |
|
| Gene Name: |
valS |
| Enzyme Class: |
|
| Biological Properties |
| General Function: |
Involved in nucleotide binding |
| Specific Function: |
Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a "posttransfer" editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner |
| Cellular Location: |
Cytoplasm |
| KEGG Pathways: |
- Aminoacyl-tRNA biosynthesis pae00970
- Valine, leucine and isoleucine biosynthesis pae00290
|
| KEGG Reactions: |
|
 | + | tRNA(Val) | + |  | + | tRNA(Val) | ↔ |  | + |  | + | L-Valyl-tRNA(Val) | + |  |
| | |
| + | | + | tRNA(Val) | ↔ | | + | | + | L-Valyl-tRNA(Val) |
| |
|
| SMPDB Reactions: |
|
L-Valine | + | | + |  | + | tRNA(Val) | + | | → | | + | Pyrophosphate | + | L-Valyl-tRNA(Val) |
| |
|
| PseudoCyc/BioCyc Reactions: |
|
| Complex Reactions: |
|
| + | | + | tRNA(Val) | → | | + | | + | L-valyl-tRNA(Val) |
| |
|
| Transports: |
Not Available |
| Metabolites: |
|
| GO Classification: |
| Component |
|---|
| cell part | | cytoplasm | | intracellular part | | Function |
|---|
| adenyl nucleotide binding | | adenyl ribonucleotide binding | | aminoacyl-tRNA ligase activity | | ATP binding | | binding | | catalytic activity | | ligase activity | | ligase activity, forming aminoacyl-tRNA and related compounds | | ligase activity, forming carbon-oxygen bonds | | nucleoside binding | | nucleotide binding | | purine nucleoside binding | | valine-tRNA ligase activity | | Process |
|---|
| biosynthetic process | | cellular macromolecule biosynthetic process | | cellular macromolecule metabolic process | | macromolecule biosynthetic process | | macromolecule metabolic process | | metabolic process | | ncRNA metabolic process | | RNA metabolic process | | translation | | tRNA aminoacylation | | tRNA aminoacylation for protein translation | | tRNA metabolic process | | valyl-tRNA aminoacylation |
|
| Gene Properties |
| Locus tag: |
PA3834 |
| Strand: |
+ |
| Entrez Gene ID: |
879905 |
| Accession: |
NP_252523.1 |
| GI: |
15599029 |
| Sequence start: |
4291356 |
| Sequence End: |
4294208 |
| Sequence Length: |
2852 |
| Gene Sequence: |
>PA3834
ATGGACAAGACTTACCAGCCGCACGCCATCGAGACTTCCTGGTACGAGACCTGGGAGTCCAACGACTACTTCGCTCCGAGCGGCGAAGGCCAGCCCTACACCATCATGATCCCGCCGCCGAACGTGACCGGCAGCCTGCACATGGGCCATGGCTTCAACAACGCGATCATGGACGCGCTGATCCGCTACCGCCGCATGCAGGGCCGCAACACCCTGTGGCAGCCGGGCACCGATCACGCCGGCATCGCCACCCAGATGGTGGTCGAGCGCCAGCTCGGCGCCCAGGGCGTGAGCCGCCACGACCTCGGCCGGGAGAAGTTCCTGGAGAAGGTCTGGGAATGGAAGGAACAGTCCGGCGGCAACATCACCCGGCAGATTCGTCGCCTGGGCTCCTCGGTGGACTGGTCGCGCGAGCGCTTCACCATGGACGACGGCCTCTCCGAAGCGGTCAAGGAAGCCTTCGTGCGCCTGCATGAAGACGGCCTGATCTACCGCGGCAAACGCCTGGTGAACTGGGACACCAAGCTGCACACCGCGATTTCCGACCTGGAAGTGGAAAACCACGACGAGAAGGGCCACCTCTGGCACCTGCGCTACCCGCTGGTGAACGGCGCGAAGACCAGCGAAGGCCTGGATTACCTGGTGGTCGCCACCACCCGTCCGGAAACCCTGCTGGGCGACGCCGCGGTCGCGGTGCACCCGGAAGACGAGCGCTACGCCAAGCTGATCGGCCAGTTCGCCGAACTGCCGATCGTCGGCCGGCACATCCCGATCATCGCCGACGAGTACGTCGACCGCGAATTCGGCACCGGCTGCGTGAAGATCACCCCGGCCCACGACTTCAACGACTACGAAGTGGGCAAGCGCCACGACCTGCCGCTGATCAACATCTTCGACAAGAACGCCGCGGTGCTGGCCCAGGCCCAGGTGTTCCACCTCGACGGCAGCGTCAACCCGAACCTCGACCCCAGCCTGCCGCAGAGCTACGCCGGCATGGACCGCTTCGCCGCGCGCAAGGCCATCGTCGCCGAGTTCGAGGCCATGGGCTTGCTCGAGAAGGTCGACGACCACGCGCTGAAAGTACCGAAGGGCGACCGCTCCGGCACCGTCATCGAGCCCTGGCTGACCGACCAGTGGTACGTCAGCACCAAGCCGCTGGCCGAAGACGCCATCGCCGCCGTGGAAGACGGCCGTATCCAGTTCGTGCCCAAGCAGTACGAGAACATGTACTTCTCCTGGATGCGCGACATCCAGGACTGGTGCATCAGCCGCCAGCTCTGGTGGGGCCACCGCATCCCGGCCTGGTACGACGAGGCCGGCAACGTCTACGTCGGCCGCGACGAGGTCGAGGTGCGCACCAAGCACAAGCTCGGCAACGAGGCCGAGTTGCGCCAGGACGAAGACGTTCTCGACACCTGGTTCAGCTCCGGCCTGTGGACCTTCTCCACCCTCGGCTGGCCGCAGCAGACCGAGTTCCTCAAGACCTTCCACCCCACCGACGTACTGGTCACCGGCTTCGACATCATCTTCTTCTGGGTCGCGCGGATGATCATGCTCACCATGCACCTGGTGAAGAACCCCGACGGCACCCCGCAGATCCCGTTCAAGACCGTCTATGTCCACGGCCTGGTGCGCGACGGCCAGGGCCAGAAGATGTCCAAGTCCAAGGGCAACGTACTCGACCCGCTGGACATCGTCGACGGCATCGACCTCGATACCCTGCTGCAAAAGCGCACCAGCGGCATGATGCAGCCGAAGCTGGCGGAGAAGATCGCCAAGCAGACCCGCGCCGAATTCCCCGAAGGCATCGCCAGCTACGGCACCGACGCCCTGCGCTTCACCTTCTGCTCGCTGGCCTCCACCGGCCGCGACATCAAGTTCGACATGGGCCGCGTCGAAGGCTTCCGCAACTTCTGCAACAAGATCTGGAACGCCGCCAACTTCGTCATCGAGAACACCGATGGCCAGGACACCGGGGTCAACGGCGAGCCGGTCGAGCTGTCCTCGGTCGACCGCTGGATCATCTCCCAGTTGCAGCGCACCGAGCAGGAAGTCACCCGCCAGCTCGACGCCTTCCGCTTCGATCTGGCCGCCCAGGCCCTCTATGAGTTCATCTGGGACGAGTACTGCGCCTGGTACCTGGAGCTGGTCAAGCCGGTGCTGTGGGACGAGAACGCCCCCATCGAGCGCCAGCGCGGCACTCGTCGCACCCTGATCCGCGTGCTGGAGACGGCCCTGCGCCTGGCGCACCCGTTCATGCCGTTCATCACCGAGGAAATCTGGCAACGCATCAAGGGCCAGGCCGGCAAGGAAGGCCCGACCCTGATGCTGCAACCCTGGCCGGTGGCCGACGAAGGCAGGATCGACGCCGCCGCCGAAGGCGACATCGAATGGGTCAAGGCGCTGATGCTCGGCGTGCGGCAGATCCGCGGCGAGATGAACATCTCCATGGCCAAGCGCATCGACATCATCCTCAAGAACGCCTCGCCCAGCGACCACCGCCGCCTGGCCGACAACGAGCCGCTGCTGATGAAACTGGCCAAGCTGGAAAGCATCCGCGTGCTGGAAGCCGGCGAGGAAGCGCCGATGTCCGCCACCGCCCTGGTCGGCGACATGGAAGTATTGGTGCCGATGGCCGGCCTGATCGACAAGAGCGCCGAACTGGGGCGCCTGGACAAGGAGATCCAGCGCCTGGAAGGCGAGGTCAAGCGCGTCGGCGGCAAGCTGTCCAACGAAGGCTTCGTCGCCAAGGCCCCGGCCGACGTGATCGAGAAGGAACGCGCCAAGCTAGCCGAGGCCGAACAGGCCCTGGCCAAGCTGGCCGAGCAACGGCAGAAGATCGCCGCGCTCTAA |
| Protein Properties |
| Protein Residues: |
950 |
| Protein Molecular Weight: |
107.7 kDa |
| Protein Theoretical pI: |
5.23 |
| Hydropathicity (GRAVY score): |
-0.378 |
| Charge at pH 7 (predicted): |
-24.53 |
| Protein Sequence: |
>PA3834
MDKTYQPHAIETSWYETWESNDYFAPSGEGQPYTIMIPPPNVTGSLHMGHGFNNAIMDALIRYRRMQGRNTLWQPGTDHAGIATQMVVERQLGAQGVSRHDLGREKFLEKVWEWKEQSGGNITRQIRRLGSSVDWSRERFTMDDGLSEAVKEAFVRLHEDGLIYRGKRLVNWDTKLHTAISDLEVENHDEKGHLWHLRYPLVNGAKTSEGLDYLVVATTRPETLLGDAAVAVHPEDERYAKLIGQFAELPIVGRHIPIIADEYVDREFGTGCVKITPAHDFNDYEVGKRHDLPLINIFDKNAAVLAQAQVFHLDGSVNPNLDPSLPQSYAGMDRFAARKAIVAEFEAMGLLEKVDDHALKVPKGDRSGTVIEPWLTDQWYVSTKPLAEDAIAAVEDGRIQFVPKQYENMYFSWMRDIQDWCISRQLWWGHRIPAWYDEAGNVYVGRDEVEVRTKHKLGNEAELRQDEDVLDTWFSSGLWTFSTLGWPQQTEFLKTFHPTDVLVTGFDIIFFWVARMIMLTMHLVKNPDGTPQIPFKTVYVHGLVRDGQGQKMSKSKGNVLDPLDIVDGIDLDTLLQKRTSGMMQPKLAEKIAKQTRAEFPEGIASYGTDALRFTFCSLASTGRDIKFDMGRVEGFRNFCNKIWNAANFVIENTDGQDTGVNGEPVELSSVDRWIISQLQRTEQEVTRQLDAFRFDLAAQALYEFIWDEYCAWYLELVKPVLWDENAPIERQRGTRRTLIRVLETALRLAHPFMPFITEEIWQRIKGQAGKEGPTLMLQPWPVADEGRIDAAAEGDIEWVKALMLGVRQIRGEMNISMAKRIDIILKNASPSDHRRLADNEPLLMKLAKLESIRVLEAGEEAPMSATALVGDMEVLVPMAGLIDKSAELGRLDKEIQRLEGEVKRVGGKLSNEGFVAKAPADVIEKERAKLAEAEQALAKLAEQRQKIAAL |
| References |
| External Links: |
|
| General Reference: |
PaperBLAST - Find papers about PA3834 and its homologs
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