Tryptophanyl-tRNA synthetase (PA4439)

Identification
Name: Tryptophanyl-tRNA synthetase
Synonyms:
  • Tryptophan--tRNA ligase
  • TrpRS
Gene Name: trpS
Enzyme Class:
Biological Properties
General Function: Involved in nucleotide binding
Specific Function: ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp)
Cellular Location: Cytoplasm
KEGG Pathways:
KEGG Reactions:
Thumb+tRNA(Trp)+Thumb+tRNA(Trp) ↔ Thumb+Thumb+L-Tryptophanyl-tRNA(Trp)
Adenosine triphosphate + tRNA(Trp) + L-Tryptophan + tRNA(Trp) ↔ Adenosine monophosphate + Pyrophosphate + L-Tryptophanyl-tRNA(Trp)
ReactionCard
Thumb+Thumb+tRNA(Trp) ↔ Thumb+Thumb+L-Tryptophanyl-tRNA(Trp)
Adenosine triphosphate + L-Tryptophan + tRNA(Trp) ↔ Adenosine monophosphate + Pyrophosphate + L-Tryptophanyl-tRNA(Trp)
ReactionCard
SMPDB Reactions:
Thumb+Thumb+Thumb+tRNA(Trp) → Thumb+Pyrophosphate+L-tryptophyl-tRNA(Trp)
L-Tryptophan + Adenosine triphosphate + Hydrogen ion + tRNA(Trp) → Adenosine monophosphate + Pyrophosphate + L-tryptophyl-tRNA(Trp)
ReactionCard
PseudoCyc/BioCyc Reactions:
Thumb+tRNA(Trp)+Thumb+tRNA(Trp) ↔ Thumb+Thumb+L-Tryptophanyl-tRNA(Trp)
Adenosine triphosphate + tRNA(Trp) + L-Tryptophan + tRNA(Trp) ↔ Adenosine monophosphate + Pyrophosphate + L-Tryptophanyl-tRNA(Trp)
ReactionCard
Thumb+Thumb+tRNA(Trp) ↔ Thumb+Thumb+L-Tryptophanyl-tRNA(Trp)
Adenosine triphosphate + L-Tryptophan + tRNA(Trp) ↔ Adenosine monophosphate + Pyrophosphate + L-Tryptophanyl-tRNA(Trp)
ReactionCard
Thumb+Thumb+tRNA(Trp) → Thumb+Thumb+L-tryptophyl-tRNA(Trp)
Adenosine triphosphate + L-Tryptophan + tRNA(Trp) → Adenosine monophosphate + Pyrophosphate + L-tryptophyl-tRNA(Trp)
ReactionCard
Thumb+Thumb+Thumb+tRNA(Trp) → Thumb+Pyrophosphate+L-tryptophyl-tRNA(Trp)
L-Tryptophan + Adenosine triphosphate + Hydrogen ion + tRNA(Trp) → Adenosine monophosphate + Pyrophosphate + L-tryptophyl-tRNA(Trp)
ReactionCard
Thumb
L-tryptophan + a tRNAtrp + ATP + H+ → an L-tryptophanyl-[tRNAtrp] + AMP + diphosphate
ReactionCard
Complex Reactions:
Thumb+Thumb+tRNA(Trp) → Thumb+Thumb+L-tryptophyl-tRNA(Trp)
Adenosine triphosphate + L-Tryptophan + tRNA(Trp) → Adenosine monophosphate + Pyrophosphate + L-tryptophyl-tRNA(Trp)
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB000014Adenosine monophosphateMetaboCard
PAMDB000148Adenosine triphosphateMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB000203L-TryptophanMetaboCard
PAMDB000633PyrophosphateMetaboCard
GO Classification:
Component
cell part
cytoplasm
intracellular part
Function
adenyl nucleotide binding
adenyl ribonucleotide binding
aminoacyl-tRNA ligase activity
ATP binding
binding
catalytic activity
ligase activity
ligase activity, forming aminoacyl-tRNA and related compounds
ligase activity, forming carbon-oxygen bonds
nucleoside binding
nucleotide binding
purine nucleoside binding
tryptophan-tRNA ligase activity
Process
biosynthetic process
cellular macromolecule biosynthetic process
cellular macromolecule metabolic process
macromolecule biosynthetic process
macromolecule metabolic process
metabolic process
ncRNA metabolic process
RNA metabolic process
translation
tRNA aminoacylation
tRNA aminoacylation for protein translation
tRNA metabolic process
tryptophanyl-tRNA aminoacylation
Gene Properties
Locus tag: PA4439
Strand: -
Entrez Gene ID: 880958
Accession: NP_253129.1
GI: 15599635
Sequence start: 4971986
Sequence End: 4973332
Sequence Length: 1346
Gene Sequence: 
>PA4439
ATGACTACTCGTATCCTGACCGGCATCACTCCTACCGGCACTCCGCACCTGGGCAACTACGCCGGCGCCATCCGCCCGGCGATCCTCGCCAGCCGTCGGAGCGACGTGGATTCGTTCTACTTCCTGGCGGACTACCACGCCTTGATCAAGTGCGACGATCCCGCTCGTATCCAGCGCTCGCGCCTGGAAATCGCCGCGACCTGGCTGGCCGGCGGCCTGGACGTCGAGCGTGCGACCTTCTACCGGCAGTCGGACATCCCCGAGATTCCCGAGCTGACCTGGTTGCTCACCTGCGTCAGTGCCAAGGGCCTGCTCAACCGCGCGCATGCCTACAAGGCCGCGGTGGACCGCAATGTCGAGGCCGGCGAAGACCCGGACGCCGGCGTGACCATGGGCCTCTACAGCTATCCGGTGCTGATGGCCGCGGACATCCTGATGTTCAACGCGCACAAGATTCCGGTCGGCCGCGACCAGGTGCAGCACGTGGAGATGGCCCGCGACATCGGCCAGCGTTTCAACCACCTGTTCGGCAACGGCCGCGAGTTCTTCGTCCTGCCCGAAGCGGTGATCGAGGAAAACGTCGCCACCCTGCCGGGCCTGGACGGGCGCAAGATGTCCAAGAGCTACGACAACACCATCCCGCTGTTCAGCCCGTCCAGGCAGCTCAAGGACGCCATCGCACGCATCGTCACCGACTCGCGCGCGCCGGGCGAGCCGAAAGACCCGGACAGTTCGCACCTGTTCCTTCTTTACTCGGCCTTCGCCAGCGCCGAACAGGTCGCCGCGTTCCGCCAGGAACTGCTCGAAGGCCTGGCCTGGGGCGAAGCCAAGCAGCGCCTGTTCCAGTTGCTCGACAACGAACTGGGCGAGGCTCGCGAGCGTTACCAGGCGCTGATCGCCAAGCCGGACGATATCGAGGACATTCTCCTCGCAGGTGCCGCCAAGGCGCGCCGCATCGCCACCCCATTCATCGCCGAGTTGCGCGAGGCAGTCGGCCTGCGCTCCCTGCGCGAGCCGCTGAAAAGTGCCGAGAGCGGCAAGAAGAAGGCCGCCAAGGCTGCGCGCCTGGTCAGCTTCCGCGACGACGACGGCAGCTTCCGCTTCCGCCTGCTGGACGCCGCCGGCGAACAGCTACTGCTGTCCCGCGCCTTCGCCGACGGCAAGGCCGCCGGTGCGGTGAGCAAGCGCCTGCTGGCTGGCGAGACTGCCGACCTGCGGGCCGAGGGCAATGCCTTTGGCCTGTGGCTGGATGGCGAGGCGGTGGCGCAGAGCCCGGCCTTCGCCGACGCCGCCGCCCGTGACGCCGCCATCGAGCGCACCCGCGAAGCGCTGGCACCGCAGGAGTAG
Protein Properties
Protein Residues: 448
Protein Molecular Weight: 49 kDa
Protein Theoretical pI: 5.77
Hydropathicity (GRAVY score): -0.199
Charge at pH 7 (predicted): -5.35
Protein Sequence: 
>PA4439
MTTRILTGITPTGTPHLGNYAGAIRPAILASRRSDVDSFYFLADYHALIKCDDPARIQRSRLEIAATWLAGGLDVERATFYRQSDIPEIPELTWLLTCVSAKGLLNRAHAYKAAVDRNVEAGEDPDAGVTMGLYSYPVLMAADILMFNAHKIPVGRDQVQHVEMARDIGQRFNHLFGNGREFFVLPEAVIEENVATLPGLDGRKMSKSYDNTIPLFSPSRQLKDAIARIVTDSRAPGEPKDPDSSHLFLLYSAFASAEQVAAFRQELLEGLAWGEAKQRLFQLLDNELGEARERYQALIAKPDDIEDILLAGAAKARRIATPFIAELREAVGLRSLREPLKSAESGKKKAAKAARLVSFRDDDGSFRFRLLDAAGEQLLLSRAFADGKAAGAVSKRLLAGETADLRAEGNAFGLWLDGEAVAQSPAFADAAARDAAIERTREALAPQE
References
External Links:
Resource Link
Genome ID: PA4439
Entrez Gene ID: 880958
NCBI Protein ID: 15599635
General Reference: PaperBLAST - Find papers about PA4439 and its homologs