Ubiquinone-1 (PAMDB001833)

General function:

Involved in magnesium ion binding

Specific function:

Pyruvate + ferricytochrome b1 + H(2)O = acetate + CO(2) + ferrocytochrome b1

Gene Name:

poxB

Locus Tag:

PA5297

Molecular weight:

62.3 kDa

Reactions

General function:

Involved in electron carrier activity

Specific function:

Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth

Gene Name:

sdhB

Locus Tag:

PA1584

Molecular weight:

26.2 kDa

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Oxidizes proline to glutamate for use as a carbon and nitrogen source and also function as a transcriptional repressor of the put operon

Gene Name:

putA

Locus Tag:

PA0782

Molecular weight:

115.6 kDa

Reactions

General function:

Involved in oxidation-reduction process

Specific function:

sn-glycerol 3-phosphate + NAD(P)(+) = glycerone phosphate + NAD(P)H

Gene Name:

gpsA

Locus Tag:

PA1614

Molecular weight:

36.8 kDa

Reactions

General function:

Involved in catalytic activity

Specific function:

(S)-dihydroorotate + a quinone = orotate + a quinol

Gene Name:

pyrD

Locus Tag:

PA3050

Molecular weight:

36.1 kDa

Reactions

General function:

Involved in electron carrier activity

Specific function:

Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth

Gene Name:

sdhA

Locus Tag:

PA1583

Molecular weight:

63.5 kDa

Reactions

General function:

Involved in succinate dehydrogenase activity

Specific function:

Membrane-anchoring subunit of succinate dehydrogenase (SDH)

Gene Name:

sdhD

Locus Tag:

PA1582

Molecular weight:

13.7 kDa

General function:

Involved in oxidoreductase activity, acting on NADH or NADPH

Specific function:

NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient

Gene Name:

nuoA

Locus Tag:

PA2637

Molecular weight:

15 kDa

Reactions

General function:

Involved in NADH dehydrogenase (ubiquinone) activity

Specific function:

NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient

Gene Name:

nuoB

Locus Tag:

PA2638

Molecular weight:

25.4 kDa

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient

Gene Name:

nuoE

Locus Tag:

PA2640

Molecular weight:

18.1 kDa

Reactions

General function:

Involved in oxidation-reduction process

Specific function:

NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone

Gene Name:

nuoH

Locus Tag:

PA2643

Molecular weight:

36.7 kDa

Reactions

General function:

Involved in electron carrier activity

Specific function:

NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient

Gene Name:

nuoI

Locus Tag:

PA2644

Molecular weight:

20.6 kDa

Reactions

General function:

Involved in NADH dehydrogenase (ubiquinone) activity

Specific function:

NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient

Gene Name:

nuoJ

Locus Tag:

PA2645

Molecular weight:

17.6 kDa

Reactions

General function:

Involved in oxidoreductase activity, acting on NADH or NADPH

Specific function:

There are 2 NADH dehydrogenases in Pseudomonas aeruginosa, however only this complex is able to use dNADH (reduced nicotinamide hypoxanthine dinucleotide, deamino-NADH) and dNADH-DB (dimethoxy- 5-methyl-6-decyl-1,4-benzoquinone) as substrates

Gene Name:

nuoK

Locus Tag:

PA2646

Molecular weight:

11 kDa

Reactions

General function:

Involved in NADH dehydrogenase (ubiquinone) activity

Specific function:

NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient

Gene Name:

nuoM

Locus Tag:

PA2648

Molecular weight:

55.7 kDa

Reactions

General function:

Involved in NADH dehydrogenase (ubiquinone) activity

Specific function:

NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient

Gene Name:

nuoN

Locus Tag:

PA2649

Molecular weight:

51.7 kDa

Reactions

General function:

Involved in oxidoreductase activity, acting on CH-OH group of donors

Specific function:

GDH is probably involved in energy conservation rather than in sugar metabolism

Gene Name:

gcd

Locus Tag:

PA2290

Molecular weight:

86.2 kDa

Reactions

General function:

Involved in 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity

Specific function:

S-adenosyl-L-methionine + 3- demethylubiquinone-9 = S-adenosyl-L-homocysteine + ubiquinone-9

Gene Name:

ubiG

Locus Tag:

PA3171

Molecular weight:

25.9 kDa

Reactions

General function:

Involved in NADH dehydrogenase (ubiquinone) activity

Specific function:

NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient

Gene Name:

nuoF

Locus Tag:

PA2641

Molecular weight:

48.7 kDa

Reactions

General function:

Involved in oxidoreductase activity, acting on NADH or NADPH

Specific function:

NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient

Gene Name:

nuoC

Locus Tag:

PA2639

Molecular weight:

68.3 kDa

Reactions

General function:

Involved in electron carrier activity

Specific function:

NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient

Gene Name:

nuoG

Locus Tag:

PA2642

Molecular weight:

99 kDa

Reactions

General function:

Involved in NADH dehydrogenase (ubiquinone) activity

Specific function:

NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient

Gene Name:

nuoL

Locus Tag:

PA2647

Molecular weight:

66.2 kDa

Reactions

General function:

Involved in succinate dehydrogenase activity

Specific function:

Membrane-anchoring subunit of succinate dehydrogenase (SDH)

Gene Name:

sdhC

Locus Tag:

PA1581

Molecular weight:

13.7 kDa

General function:

Involved in cytochrome bo3 ubiquinol oxidase activity

Specific function:

Cytochrome o terminal oxidase complex is the component of the aerobic respiratory chain of Pseudomonas aeruginosa that predominates when cells are grown at high aeration

Gene Name:

cyoA

Locus Tag:

PA1317

Molecular weight:

36.6 kDa

Reactions

General function:

Involved in cytochrome o ubiquinol oxidase activity

Specific function:

Cytochrome o terminal oxidase complex is the component of the aerobic respiratory chain of Pseudomonas aeruginosa that predominates when cells are grown at high aeration

Gene Name:

cyoD

Locus Tag:

PA1320

Molecular weight:

12.1 kDa

General function:

Involved in cytochrome-c oxidase activity

Specific function:

Cytochrome o terminal oxidase complex is the component of the aerobic respiratory chain of Pseudomonas aeruginosa that predominates when cells are grown at high aeration. This ubiquinol oxidase shows proton pump activity across the membrane in addition to the electron transfer

Gene Name:

cyoB

Locus Tag:

PA1318

Molecular weight:

73.9 kDa

Reactions

General function:

Involved in heme-copper terminal oxidase activity

Specific function:

Cytochrome o terminal oxidase complex is the component of the aerobic respiratory chain of Pseudomonas aeruginosa that predominates when cells are grown at high aeration

Gene Name:

cyoC

Locus Tag:

PA1319

Molecular weight:

22.8 kDa

Reactions