| Identification |
| Name: |
NADH-quinone oxidoreductase subunit C/D |
| Synonyms: |
- NADH dehydrogenase I subunit C/D
- NDH-1 subunit C/D
- NUO3/NUO4
|
| Gene Name: |
nuoC |
| Enzyme Class: |
|
| Biological Properties |
| General Function: |
Involved in oxidoreductase activity, acting on NADH or NADPH |
| Specific Function: |
NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient |
| Cellular Location: |
Cytoplasm. Cell inner membrane; Peripheral membrane protein |
| KEGG Pathways: |
|
| KEGG Reactions: |
|
| SMPDB Reactions: |
| | |
 | + | 4  | + | 2 | + | menaquinone-8 | ? |  | + | | + |  | + | Electron | + | 4 |
| | |
"a menaquinone" | + | 4 | + | | → | "a menaquinol" | + | |
| | |
4 | + | | + | "a menaquinone" | → | | + | "a menaquinol" |
| |
|
| PseudoCyc/BioCyc Reactions: |
|
| Complex Reactions: |
|
| Transports: |
Not Available |
| Metabolites: |
|
| GO Classification: |
| Function |
|---|
| binding | | catalytic activity | | cofactor binding | | NAD or NADH binding | | NADH dehydrogenase (quinone) activity | | NADH dehydrogenase (ubiquinone) activity | | NADH dehydrogenase activity | | nucleotide binding | | oxidoreductase activity | | oxidoreductase activity, acting on NADH or NADPH | | quinone binding | | Process |
|---|
| metabolic process | | oxidation reduction |
|
| Gene Properties |
| Locus tag: |
PA2639 |
| Strand: |
+ |
| Entrez Gene ID: |
882346 |
| Accession: |
NP_251329.1 |
| GI: |
15597835 |
| Sequence start: |
2983963 |
| Sequence End: |
2985744 |
| Sequence Length: |
1781 |
| Gene Sequence: |
>PA2639
ATGACTGCAGACTCCGCTCTGTACATCCCGCCTTACAAGGCAGACGACCAGGATATCGTCGTCGAACTGAACTCCCGCTTTGGCGCCGAGACCTTCACCGTCCAGCCCACCCGTACCGGCATGCCGGTGCTCTGGGTTCCGCGCGAAAGACTGATCGAAGTCCTGACCTTCCTCCGTCAGGTACCCAAGCCCTACGTGATGCTCTACGACCTGCACGGCGTCGACGAGCGGTTGCGCACCCATCGCCGCGGCCTGCCGAGCGCCGACTTCAGCGTGTTCTACCACCTGATGTCGCTGGAGCGTAATAGTGACGTGATGATCAAGGTCGCCTTGTCCGAGCGCGACCTCAACCTGCCCACCGCCACCCGTATCTGGCCCAACGCCAACTGGTACGAGCGCGAAGTGTGGGACATGTACGGCATCACCTTCACCGGCCACCCGCACCTGACCCGCATGCTGATGCCGCCGACCTGGCAGGGCCATCCGCTGCGCAAGGACTACCCGGCGCGCGCCACCGAGTTCGATCCCTACTCCCTGTCCGCCGCCAAGCAGGACCTGGAGCAGGAAGCCCTGCGCTTCAAGCCGGAAGACTGGGGCATGAAGCGCCACGGCGAGAACGAGGACTACATGTTCCTCAACCTCGGCCCGAACCACCCGTCCGCCCACGGCGCGTTCCGCATCATCCTGCAACTGGACGGCGAGGAGATCATCGACTGCGTCCCGGAGATCGGCTACCACCACCGCGGCGCCGAGAAGATGGCCGAGCGCCAGTCCTGGCACAGTTTCATCCCCTACACCGACCGCATCGACTACCTCGGCGGGGTGATGAACAACCTGCCCTACGTACTCTCGGTGGAGAAGCTCGCCGGGATCAAGGTGCCCCAGCGGGTCGACGTGATCCGGATCATGATGGCGGAGTTCTTCCGTATCCTGAACCACCTGCTGTACCTGGGCACCTATATCCAGGACGTCGGCGCCATGACCCCGGTGTTCTTCACCTTCACCGACCGCCAGCGCGCCTACAAGGTGGTCGAGGCCATCACCGGCTTCCGCCTGCACCCGGCCTGGTACCGCATCGGCGGCGTCGCCCACGACCTGCCGCGCGGCTGGGACAAGCTGGTCCGCGAGTTCCTCGACTGGATGCCCAAGCGCCTCGACGAGTACGAGACCGCGGCCCTGAAGAACAGCATCCTGCGCGGCCGGACCATCGGCGTCGCCCAGTACAACACCAAGGAAGCCCTCGAGTGGGGCACCACCGGCGCCGGCCTGCGCGCCACCGGTTGCGACTTCGACCTGCGCAAGGCCCGCCCCTACTCCGGCTACGAGAACTTCGAGTTCGAGGTACCGCTGGCCCACAACGGCGACGCCTACGACCGCTGCATGGTCAAGATGGGCGAGATGCGCCAGAGCCTGCGGATCATCGAACAGTGCCTGAAGAACATGCCGGAAGGCCCTTACAAGGCCGACCATCCGCTGACCACGCCGCCGCCGAAAGAACGCACGCTGCAACACATCGAAACCCTGATCACCCACTTCCTGCAGGTTTCCTGGGGCCCGGTCATGCCGGCCAACGAAGCCTTCCAGATGATCGAGGCGACCAAGGGTATCAACAGCTACTACCTGACCAGCGACGGCAGCACCATGAGCTACCGCACGCGTATCCGGACGCCCAGCTTCGCGCACCTGCAACAGATCCCCTCGGTGATCAACGGCAGCATGATCGCGGATCTGATCGCCTACCTGGGTAGCATCGATTTCGTTATGGCTGACGTGGACCGCTGA |
| Protein Properties |
| Protein Residues: |
593 |
| Protein Molecular Weight: |
68.3 kDa |
| Protein Theoretical pI: |
6.68 |
| Hydropathicity (GRAVY score): |
-0.351 |
| Charge at pH 7 (predicted): |
-3.29 |
| Protein Sequence: |
>PA2639
MTADSALYIPPYKADDQDIVVELNSRFGAETFTVQPTRTGMPVLWVPRERLIEVLTFLRQVPKPYVMLYDLHGVDERLRTHRRGLPSADFSVFYHLMSLERNSDVMIKVALSERDLNLPTATRIWPNANWYEREVWDMYGITFTGHPHLTRMLMPPTWQGHPLRKDYPARATEFDPYSLSAAKQDLEQEALRFKPEDWGMKRHGENEDYMFLNLGPNHPSAHGAFRIILQLDGEEIIDCVPEIGYHHRGAEKMAERQSWHSFIPYTDRIDYLGGVMNNLPYVLSVEKLAGIKVPQRVDVIRIMMAEFFRILNHLLYLGTYIQDVGAMTPVFFTFTDRQRAYKVVEAITGFRLHPAWYRIGGVAHDLPRGWDKLVREFLDWMPKRLDEYETAALKNSILRGRTIGVAQYNTKEALEWGTTGAGLRATGCDFDLRKARPYSGYENFEFEVPLAHNGDAYDRCMVKMGEMRQSLRIIEQCLKNMPEGPYKADHPLTTPPPKERTLQHIETLITHFLQVSWGPVMPANEAFQMIEATKGINSYYLTSDGSTMSYRTRIRTPSFAHLQQIPSVINGSMIADLIAYLGSIDFVMADVDR |
| References |
| External Links: |
|
| General Reference: |
PaperBLAST - Find papers about PA2639 and its homologs
|
