Dihydroorotate dehydrogenase (PA3050)

Identification
Name: Dihydroorotate dehydrogenase
Synonyms:
  • DHOdehase
  • DHOD
  • DHODase
  • Dihydroorotate oxidase
Gene Name: pyrD
Enzyme Class:
Biological Properties
General Function: Involved in catalytic activity
Specific Function: (S)-dihydroorotate + a quinone = orotate + a quinol
Cellular Location: Cell membrane; Peripheral membrane protein
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb ↔ Thumb+Thumb
4,5-Dihydroorotic acid + Fumaric acid ↔ Orotic acid + Succinic acid
ReactionCard
Thumb+Thumb ↔ Thumb+Thumb
4,5-Dihydroorotic acid + Quinone ↔ Orotic acid + Hydroquinone
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SMPDB Reactions:
4,5-Dihydroorotic acid+Thumb+Thumb → Thumb+Thumb
4,5-Dihydroorotic acid + Ubiquinone-1 + 4,5-Dihydroorotic acid → Ubiquinol-1 + Orotic acid
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PseudoCyc/BioCyc Reactions:
Thumb+a ubiquinone → Thumb+a ubiquinol
4,5-Dihydroorotic acid + a ubiquinone → Orotic acid + a ubiquinol
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Thumb+a menaquinone → Thumb+a menaquinol
4,5-Dihydroorotic acid + a menaquinone → Orotic acid + a menaquinol
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Complex Reactions:
Thumb+Thumb → Thumb+Thumb
4,5-Dihydroorotic acid + Ubiquinone-8 → Orotic acid + Ubiquinol-8
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Thumb+Menaquinone 8 → Thumb+Thumb
4,5-Dihydroorotic acid + Menaquinone 8 → Menaquinol 8 + Orotic acid
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Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB0001474,5-Dihydroorotic acidMetaboCard
PAMDB000073Fumaric acidMetaboCard
PAMDB000459HydroquinoneMetaboCard
PAMDB001653Menaquinol 8MetaboCard
PAMDB000094Orotic acidMetaboCard
PAMDB003450QuinoneMetaboCard
PAMDB000107Succinic acidMetaboCard
PAMDB001968Ubiquinol-1MetaboCard
PAMDB000237Ubiquinol-8MetaboCard
PAMDB001833Ubiquinone-1MetaboCard
PAMDB001700Ubiquinone-8MetaboCard
GO Classification:
Component
cell part
membrane
Function
catalytic activity
dihydroorotate dehydrogenase activity
dihydroorotate oxidase activity
oxidoreductase activity
oxidoreductase activity, acting on the CH-CH group of donors
oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor
Process
'de novo' pyrimidine base biosynthetic process
cellular aromatic compound metabolic process
cellular metabolic process
cellular nitrogen compound metabolic process
metabolic process
nitrogen compound metabolic process
nucleobase metabolic process
nucleobase, nucleoside and nucleotide metabolic process
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
nucleoside phosphate metabolic process
nucleotide metabolic process
oxidation reduction
pyrimidine base biosynthetic process
pyrimidine base metabolic process
pyrimidine nucleoside monophosphate biosynthetic process
pyrimidine nucleotide biosynthetic process
pyrimidine nucleotide metabolic process
pyrimidine ribonucleoside monophosphate biosynthetic process
UMP biosynthetic process
Gene Properties
Locus tag: PA3050
Strand: -
Entrez Gene ID: 882867
Accession: NP_251740.1
GI: 15598246
Sequence start: 3414701
Sequence End: 3415729
Sequence Length: 1028
Gene Sequence: 
>PA3050
ATGTACACCCTGGCCCGCCAGCTGCTGTTCAAACTGTCCCCGGAAACCTCCCACGAACTGTCCATCGACCTGATCGGGGCCGGCGGCCGCCTGGGCCTGAACCGCCTGCTGACGCCCAAGCCGGCCAGTCTGCCGGTCTCTGTGCTGGGCCTGGAGTTTCCCAACCCGGTGGGGCTGGCCGCGGGCCTGGACAAGAACGGCGACGCCATCGACGGGTTCGGCCAGCTCGGTTTCGGCTTCATCGAGATCGGCACCGTCACTCCGCGACCGCAGCCGGGCAATCCCAGGCCGCGCCTGTTCCGCCTGCCGCAAGCCAACGCGATCATCAATCGCATGGGTTTCAACAACCACGGCGTCGACCACCTGCTGGCGCGGGTGCGTGCGGCGAAGTATCGCGGCGTGCTGGGGATCAACATCGGCAAGAACTTCGATACCCCGGTGGAGCGCGCGGTCGACGACTACCTGATCTGCCTGGACAAGGTCTACGCCGACGCCAGCTACGTCACCGTCAACGTCAGCTCGCCGAACACGCCCGGCCTGCGCAGCCTGCAGTTCGGCGATTCGCTCAAGCAACTGCTGGAGGCACTGCGCCAGCGTCAGGAAGCGCTGGCGCTGCGGCATGGCCGGCGGGTACCGCTGGCGATCAAGATCGCCCCGGACATGACCGACGAAGAGACCGCGCTGGTCGCCGCGGCGCTGGTCGAGGCGGGGATGGACGCGGTGATCGCGACCAATACCACTCTCGGCCGCGAAGGCGTGGAAGGCCTGCCGCATGGCGACGAGGCGGGTGGCCTGTCCGGCGCGCCGGTGCGGGAAAAGAGCACGCACACGGTGAAGGTGCTGGCCGGCGAACTGGGCGGACGGCTGCCGATCATCGCCGCCGGCGGTATCACCGAGGGCGCGCACGCGGCGGAGAAGATCGCCGCCGGGGCGAGCCTGGTGCAGATCTATTCGGGTTTCATCTACAAGGGACCGGCGTTGATCCGCGAAGCGGTGGACGCCATCGCCGCATTGCCGCGGCGGAATTGA
Protein Properties
Protein Residues: 342
Protein Molecular Weight: 36.1 kDa
Protein Theoretical pI: 8.93
Hydropathicity (GRAVY score): 0.027
Charge at pH 7 (predicted): 3.65
Protein Sequence: 
>PA3050
MYTLARQLLFKLSPETSHELSIDLIGAGGRLGLNRLLTPKPASLPVSVLGLEFPNPVGLAAGLDKNGDAIDGFGQLGFGFIEIGTVTPRPQPGNPRPRLFRLPQANAIINRMGFNNHGVDHLLARVRAAKYRGVLGINIGKNFDTPVERAVDDYLICLDKVYADASYVTVNVSSPNTPGLRSLQFGDSLKQLLEALRQRQEALALRHGRRVPLAIKIAPDMTDEETALVAAALVEAGMDAVIATNTTLGREGVEGLPHGDEAGGLSGAPVREKSTHTVKVLAGELGGRLPIIAAGGITEGAHAAEKIAAGASLVQIYSGFIYKGPALIREAVDAIAALPRRN
References
External Links:
Resource Link
Genome ID: PA3050
Entrez Gene ID: 882867
NCBI Protein ID: 15598246
General Reference: PaperBLAST - Find papers about PA3050 and its homologs