Identification
Name: NADH-quinone oxidoreductase subunit G
Synonyms:
  • NADH dehydrogenase I subunit G
  • NDH-1 subunit G
  • NUO7
Gene Name: nuoG
Enzyme Class:
Biological Properties
General Function: Involved in electron carrier activity
Specific Function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Cellular Location: Cytoplasm. Cell inner membrane; Peripheral membrane protein
KEGG Pathways:
KEGG Reactions:
Thumb+AcceptorThumb+Reduced acceptor
Ubiquinol-8 + Acceptor ↔ Ubiquinone-1 + Reduced acceptor
ReactionCard
Thumb+ThumbThumb+Thumb
SMPDB Reactions:
Thumb+5 Thumb+ThumbThumb+Thumb+Thumb
Thumb+4 Thumb+2 Thumb+menaquinone-8 ? Thumb+Thumb+Thumb+Electron+4 Thumb
"a menaquinone"+4 Thumb+Thumb"a menaquinol"+Thumb
"a menaquinone" + 4 Hydrogen ion + NADH → "a menaquinol" + NAD
ReactionCard
4 Thumb+Thumb+"a menaquinone"Thumb+"a menaquinol"
4 Hydrogen ion + NADH + "a menaquinone" → NAD + "a menaquinol"
ReactionCard
PseudoCyc/BioCyc Reactions:
Thumb+AcceptorThumb+Reduced acceptor
Ubiquinol-8 + Acceptor ↔ Ubiquinone-1 + Reduced acceptor
ReactionCard
Thumb+ThumbThumb+Thumb
Thumb+ThumbThumb+Thumb
Thumb+ThumbThumb+Thumb
Thumb+ThumbThumb+Thumb
Thumb+ThumbThumb+Thumb
Thumb+ThumbThumb+Thumb
Thumb+ThumbThumb+Thumb
Thumb+ThumbThumb+Thumb
Thumb+ThumbThumb+Thumb
Thumb+5 Thumb+ThumbThumb+Thumb+Thumb
Thumb+4 Thumb+2 Thumb+menaquinone-8 ? Thumb+Thumb+Thumb+Electron+4 Thumb
Thumb
NADH + an oxidized unknown electron acceptor + H+ = NAD+ + an reduced unknown electron acceptor
ReactionCard
PAMDB110540+PAMDB001633+ETR-QuinonesPAMDB110542+ETR-Quinols
NADH + Hydrogen ion + ETR-Quinones → NAD+ + ETR-Quinols
ReactionCard
PAMDB000610+PAMDB110540+PAMDB001633PAMDB120506+PAMDB110542
Complex Reactions:
Thumb+4 Thumb+ThumbThumb+Thumb+3 Thumb
4 Thumb+Thumb+ThumbThumb+Thumb+3 Thumb
4 Thumb+Menaquinone 8+ThumbThumb+Thumb+3 Thumb
Thumb+ThumbThumb+Thumb
Thumb+ThumbThumb+Thumb
Thumb+ThumbThumb+Thumb
Thumb+ThumbThumb+Thumb
Thumb+ThumbThumb+Thumb
Thumb+ThumbThumb+Thumb
Thumb+ThumbThumb+Thumb
Thumb+ThumbThumb+Thumb
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB0015632-Demethylmenaquinol 8MetaboCard
PAMDB0015642-Demethylmenaquinone 8MetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB000459HydroquinoneMetaboCard
PAMDB001653Menaquinol 8MetaboCard
PAMDB000197NADMetaboCard
PAMDB000398NADHMetaboCard
PAMDB003450QuinoneMetaboCard
PAMDB001968Ubiquinol-1MetaboCard
PAMDB000237Ubiquinol-8MetaboCard
PAMDB001833Ubiquinone-1MetaboCard
PAMDB001700Ubiquinone-8MetaboCard
GO Classification:
Component
cell part
membrane
Function
binding
catalytic activity
cation binding
electron carrier activity
ion binding
iron-sulfur cluster binding
metal cluster binding
metal ion binding
molybdenum ion binding
NADH dehydrogenase (quinone) activity
NADH dehydrogenase (ubiquinone) activity
NADH dehydrogenase activity
oxidoreductase activity
oxidoreductase activity, acting on NADH or NADPH
transition metal ion binding
Process
ATP synthesis coupled electron transport
cellular metabolic process
electron transport chain
generation of precursor metabolites and energy
metabolic process
oxidation reduction
respiratory electron transport chain
Gene Properties
Locus tag: PA2642
Strand: +
Entrez Gene ID: 882349
Accession: NP_251332.1
GI: 15597838
Sequence start: 2987721
Sequence End: 2990438
Sequence Length: 2717
Gene Sequence:
>PA2642
ATGGCCACTATCCACGTAGACGGCAAGACGCTCGAAGTCGATGGTGCAGACAACCTCCTGCAGGCCTGTCTGTCCCTCGGTCTCGACATTCCCTACTTCTGCTGGCACCCGGCGCTCGGTAGCGTCGGCGCCTGCCGCCAGTGCGCGGTGAAGCAGTACACCGACGAGAACGACAAGCGTGGTCGCCTCGTCATGTCCTGCATGACCCCCGCCACCGACAACACCTGGATCTCCATCGAAGACGAAGAGGCCAAGCAGTTCCGCGCCAGCGTCGTCGAATGGCTGATGACCAACCACCCGCACGACTGCCCGGTGTGCGAGGAAGGCGGTCACTGCCACCTGCAGGACATGACGGTGATGACCGGCCACAACGAGCGCCGGTACCGCTTCACCAAGCGCACCCACCAGAACCAGGAACTCGGCCCGTTCATCGCCCATGAGATGAACCGCTGCATCGCCTGCTACCGCTGCGTGCGCTACTACAAGGACTACGCCGGCGGCACCGACCTCGGCGTCTACGGCGCCCACGACAACGTCTACTTCGGACGGGTCGAGGACGGCGTGCTGGAAAGCGAGTTCTCCGGCAACCTCACCGAGGTCTGCCCCACCGGCGTGTTCACCGACAAGACCCACTCCGAGCGCTACAACCGCAAGTGGGACATGCAGTTCGCCCCGAGCATCTGCCACGGCTGCTCCAGCGGCTGCAACATCAGCCCCGGCGAGCGCTACGGCGAGATCCGCCGCATCGAGAACCGCTACAACGGCTCGGTCAACCACTACTTCCTCTGCGACCGCGGTCGCTTCGGCTACGGCTACGTCAACCGCGAAGACCGTCCGCGCCAGCCGCTGCTGGTGCTGAGCAAGCAGAAGCTGAGCCTGGACGGCGCCCTCGACCAGGCCGCCGCCCTGCTGAAGGAGCGCAAGGTGGTCGGCATCGGTTCGCCGCGCGCCAGCCTGGAAAGCAACTTCGCCCTGCGCGAGCTGGTTGGCGAAGGCAACTTCTACAGCGGCATCAACGAAGGCGAGCTCGACCGCCTGCGCCTGATCCTGCAGGTCATGCAGGAAGGCCCGCTGCCGGTGCCGAGCATCCGCGACATCGAGGACCACGACGCGGTCTTCGTCCTCGGCGAGGACCTGACCCAGACCGCCGCCCGCATCGCCCTGGCCCTGCGCCAGTCGGTGAAGGGCAAGGCCGTCGAGATGGCTGCCGACATGAAGGTCCAGCCGTGGCTCGACGCCGCGGTGAAGAACATCGCCCAGCATGCGCAGAACCCACTGTTCATCGCCAGCGTCAGCGCGACCCGCCTCGACGACGTGGCCGAGGAAACCGTTCACGCCGCGCCGGACGATCTCGCTCGCCTCGGCTTCGCCGTGGCCCACGCGATCGACCCAAGCGCCCCGTCCGTGGCCGACCTCGACCCGCAGGCCCAGGCCTTCGCCCAGCGCATCACCGATGCCCTGCTGGCGGCCAAGCGTCCGCTGGTAGTGTCCGGCAACTCGCTGGGCAACAAGGCATTGATCGAAGCCGCGGCGAACATCGCCAAAGCCCTCAAGCAGCGCGAGAAGAACGGTTCCATCAGCCTGGTGGTCGGCGAAGCCAACAGCCTCGGCCTGGCGCTCTTCGGCGGCGACTCCGTGGAAGCCGCGCTCGAGCGACTGACCTCCGGACAGGCCGACGCCGTGGTGGTGCTGGAGAACGATCTCTATCGCCGCACCGACGCCGCCCGTGTCGACGCGGCCCTGGCGGCGGCCAAGGTGGTGATCGTCGCCGATCACCAGCAGACCGCCACCACCGCCAAGGCGCACCTGGTGCTGCCGGCGGCCAGCTTCGCCGAAGGCGACGGCACCCTGGTCAGCCAGGAAGGCCGCGCCCAGCGCTTCTTCCAGGTGTTCGACCCGACCTACTACGACGCCAGGAACATGGTCCGCGAGGGCTGGCGCTGGCTGCATGCGATCCACAGCACCCTGCAAGGCAAGCGCGTCGACTGGACCCAGTTGGACCACGTCACCGAAGCCGTGGCCGAGGCCAAGCCGATCCTGGCCGGCATCCGCGACGCCGCACCGGCCGCCTCGTTCCGCATCAAGGGCCTCAAGCTGGCCCGCGAACCGCACCGCTACAGCGGGCGCACCGCCATGCGCGCCAATATCAGCGTGCACGAGCCGCGCACCCCGCAGGACATCGACTCGGCGTTCGCCTTCTCCATGGAAGGCTACTCCGGCAGCCAGGAAGACCGTCAGCAGATCCCGTTCGCCTGGTCGCCGGGCTGGAACTCGCCGCAGGCCTGGAACAAGTTCCAGGACGAGGTCGGCGGCCACCTGCGCGCCGGCGACCCCGGCGTGCGCCTGATCGAACCGAAGGGCGAAGGCCTCGACTGGTTCCAGGCCGTGCCGGTGCCGTTCAGCGCCAAGGCCGACAGCTGGAAGGTAGTGCCGCTGTACCACCTGTTCGGCAGCGAGGAAAACAGCTCGCGGGCCGCGCCGATCCAGCAGCGCATCCCGGAGACCTACGTCGCCCTGTCCAAGGAAGACGCGGACCGCCTCGGCGTCAACGACGGCGCGACCCTCGGCTTCCAGCTCAAGGGCCAGGCCCTGCGCCTGCCGCTGCGTATCGATGAACAACTCGGCGCCGGCCTGATCGGCCTGCCGGTCGGCTTCGCCGGTATCCCGGCGGCGATCGCCGGCTGCTCCGTGGAAGGTCTGCAGGAGGCTGCACAATGA
Protein Properties
Protein Residues: 905
Protein Molecular Weight: 99 kDa
Protein Theoretical pI: 5.99
Hydropathicity (GRAVY score): -0.279
Charge at pH 7 (predicted): -15.2
Protein Sequence:
>PA2642
MATIHVDGKTLEVDGADNLLQACLSLGLDIPYFCWHPALGSVGACRQCAVKQYTDENDKRGRLVMSCMTPATDNTWISIEDEEAKQFRASVVEWLMTNHPHDCPVCEEGGHCHLQDMTVMTGHNERRYRFTKRTHQNQELGPFIAHEMNRCIACYRCVRYYKDYAGGTDLGVYGAHDNVYFGRVEDGVLESEFSGNLTEVCPTGVFTDKTHSERYNRKWDMQFAPSICHGCSSGCNISPGERYGEIRRIENRYNGSVNHYFLCDRGRFGYGYVNREDRPRQPLLVLSKQKLSLDGALDQAAALLKERKVVGIGSPRASLESNFALRELVGEGNFYSGINEGELDRLRLILQVMQEGPLPVPSIRDIEDHDAVFVLGEDLTQTAARIALALRQSVKGKAVEMAADMKVQPWLDAAVKNIAQHAQNPLFIASVSATRLDDVAEETVHAAPDDLARLGFAVAHAIDPSAPSVADLDPQAQAFAQRITDALLAAKRPLVVSGNSLGNKALIEAAANIAKALKQREKNGSISLVVGEANSLGLALFGGDSVEAALERLTSGQADAVVVLENDLYRRTDAARVDAALAAAKVVIVADHQQTATTAKAHLVLPAASFAEGDGTLVSQEGRAQRFFQVFDPTYYDARNMVREGWRWLHAIHSTLQGKRVDWTQLDHVTEAVAEAKPILAGIRDAAPAASFRIKGLKLAREPHRYSGRTAMRANISVHEPRTPQDIDSAFAFSMEGYSGSQEDRQQIPFAWSPGWNSPQAWNKFQDEVGGHLRAGDPGVRLIEPKGEGLDWFQAVPVPFSAKADSWKVVPLYHLFGSEENSSRAAPIQQRIPETYVALSKEDADRLGVNDGATLGFQLKGQALRLPLRIDEQLGAGLIGLPVGFAGIPAAIAGCSVEGLQEAAQ
References
External Links:
Resource Link
Genome ID: PA2642
Entrez Gene ID: 882349
NCBI Protein ID: 15597838
General Reference: PaperBLAST - Find papers about PA2642 and its homologs