| Identification |
| Name: |
NADH-quinone oxidoreductase subunit L |
| Synonyms: |
- NADH dehydrogenase I subunit L
- NDH-1 subunit L
- NUO12
|
| Gene Name: |
nuoL |
| Enzyme Class: |
|
| Biological Properties |
| General Function: |
Involved in NADH dehydrogenase (ubiquinone) activity |
| Specific Function: |
NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient |
| Cellular Location: |
Cell inner membrane; Multi-pass membrane protein |
| KEGG Pathways: |
|
| KEGG Reactions: |
|
 | + | Acceptor | ↔ |  | + | Reduced acceptor |
| | | |
|
| SMPDB Reactions: |
| | |
 | + | 4  | + | 2 | + | menaquinone-8 | ? |  | + | | + |  | + | Electron | + | 4 |
| | |
"a menaquinone" | + | 4 | + | | → | "a menaquinol" | + | |
| | |
4 | + | | + | "a menaquinone" | → | | + | "a menaquinol" |
| |
|
| PseudoCyc/BioCyc Reactions: |
|
| Complex Reactions: |
|
| Transports: |
Not Available |
| Metabolites: |
|
| GO Classification: |
| Function |
|---|
| catalytic activity | | NADH dehydrogenase (quinone) activity | | NADH dehydrogenase (ubiquinone) activity | | NADH dehydrogenase activity | | oxidoreductase activity | | oxidoreductase activity, acting on NADH or NADPH | | Process |
|---|
| ATP synthesis coupled electron transport | | cellular metabolic process | | electron transport chain | | generation of precursor metabolites and energy | | metabolic process | | oxidation reduction | | respiratory electron transport chain |
|
| Gene Properties |
| Locus tag: |
PA2647 |
| Strand: |
+ |
| Entrez Gene ID: |
882356 |
| Accession: |
NP_251337.1 |
| GI: |
15597843 |
| Sequence start: |
2992853 |
| Sequence End: |
2994700 |
| Sequence Length: |
1847 |
| Gene Sequence: |
>PA2647
ATGAACCTTCTACCTCTTACCTTCCTGTTCCCCCTGGTCGGCTTCCTGCTGCTGTCGTTCTCCCGCGGCAGGTGGTCGGAAAACCTTTCGGCGCTGGTCGGCGTCGGCTCGGTCGGCCTCTCCGCCCTGAGCGCGGCCTGGGCCATCTTCAGCTTCCACAGCAGTCCGCCGGAAGGCGGTGCCTACAGCCTGGTGCTGTGGCAGTGGATGGCGGCCGGCGACTTCAGCACCAACTTCACCCTGTACCTGGACGGCCTCTCGGTAACCATGCTCGGCGTGGTTACCGGCGTCGGCTTCCTGATCCACCTGTTTGCCTCCTGGTACATGCGTGGCGAAACCGGCTATTCGCGCTTCTTCGCCTACACCAACCTGTTCATCGCCAGCATGCTGTTCCTGGTGCTGGGCGACAACCTGCTGTTCCTCTACTTCGGCTGGGAAGGCGTGGGCCTGTGCAGCTACCTGCTGATCGGCTTCTACTACAGCAATCGCAACAACGGTAACGCGGCGCTCAAGGCATTCATCGTCACCCGCGTCGGCGACGTGTTCATGGCTTTCGGCCTGTTCATCCTGTTCCAGCAGTTCGGCACCCTGAACATCCAGGAGCTGCTGGTGCTGGCGCCGCAGAAGTTCCCGGAAGGCAACCTCTGGCTGACCCTGGCGACCCTGGCCCTGCTCGGCGGCGCGGTCGGCAAGTCCGCCCAGCTGCCGCTGCAGACCTGGCTGGCCGACGCCATGGCCGGCCCGACCCCGGTCTCCGCGCTGATCCACGCCGCCACCATGGTGACCGCCGGCGTCTACCTGATCGCCCGTTGCCACGGCCTGTTCACCCTGGCCCCGGACATCCTCGAACTGGTCGGCATCGTCGGCGCGGTGACCTTGGTCCTGGCCGGCTTCGCCGCCCTGGTACAGACCGATATCAAGCGCATCCTCGCCTACTCGACCATGAGCCAGATCGGCTACATGTTCCTCGCCCTCGGCGTCGGCGCCTGGGACGCGGCGATCTTCCACCTGATGACCCACGCCTTCTTCAAGGCCCTGCTGTTCCTTGCCTCGGGCGCGGTGATCGTCGCCTGCCACCACGAGCAGAACATCTTCAAGATGGGCGGCTTGTGGAAGAAGCTGCCGCTGGCCTACGCCAGCTTCGTGGTCGGCGGTGCGGCGCTGGCCGCCCTGCCCTTCCTCACCGCGGGCTTCTACTCCAAGGACGAGATCCTCTGGGAGGCCTTCGCCAGCGGCCATCGCGAACTGCTGATCGCCGGCCTGGTGGGTGCGTTCCTGACCTCGATCTACACCTTCCGCCTGATCTTCGTCGCCTTCCACGGCGAGCCGAAGACCGAAGCCCACGCCGGCCACGGGATTTCCCACTGGTTGCCGCTCAGCGTGCTGATCGTCCTGTCGACCTTCGTCGGCGCCCTGATCACCCCGCCGCTGGCTGGCGTCCTGCCGGAAAGCGTCGGCCACGCCGGTGGCGAAGCCAAGCACAGCCTGGAACTGGCCTCGGGTGCCATCGCCATCGCCGGTATCCTGCTGGCCGCCCTGCTCTTCCTCGGCCAGCGCCGCTTCGTCAGCGCCCTGGCGAAGAGCGCCCCGGGTCGCTTCTTCGGTACCTGGTGGTACCACGCCTGGGGCTTCGACTGGCTGTACGACAAGCTGTTCGTGAAACCCTACCTGCTGCTCTGCCAATTGCTGGGGCGCGACCCCATCGACCGTACCCTGGGCGTCGTTCCGTTCAGCGTGCGCGGCGGACACAACCTCCTCAGCCTCACCGAGAACGGCCGCCTGCGCTGGTACGCCGCTTCCCTGGTGGGTGGCGCCGCCATCCTGCTCGGCGCGCTGCTGCTGGCCTAA |
| Protein Properties |
| Protein Residues: |
615 |
| Protein Molecular Weight: |
66.2 kDa |
| Protein Theoretical pI: |
8.31 |
| Hydropathicity (GRAVY score): |
0.784 |
| Charge at pH 7 (predicted): |
5.95 |
| Protein Sequence: |
>PA2647
MNLLPLTFLFPLVGFLLLSFSRGRWSENLSALVGVGSVGLSALSAAWAIFSFHSSPPEGGAYSLVLWQWMAAGDFSTNFTLYLDGLSVTMLGVVTGVGFLIHLFASWYMRGETGYSRFFAYTNLFIASMLFLVLGDNLLFLYFGWEGVGLCSYLLIGFYYSNRNNGNAALKAFIVTRVGDVFMAFGLFILFQQFGTLNIQELLVLAPQKFPEGNLWLTLATLALLGGAVGKSAQLPLQTWLADAMAGPTPVSALIHAATMVTAGVYLIARCHGLFTLAPDILELVGIVGAVTLVLAGFAALVQTDIKRILAYSTMSQIGYMFLALGVGAWDAAIFHLMTHAFFKALLFLASGAVIVACHHEQNIFKMGGLWKKLPLAYASFVVGGAALAALPFLTAGFYSKDEILWEAFASGHRELLIAGLVGAFLTSIYTFRLIFVAFHGEPKTEAHAGHGISHWLPLSVLIVLSTFVGALITPPLAGVLPESVGHAGGEAKHSLELASGAIAIAGILLAALLFLGQRRFVSALAKSAPGRFFGTWWYHAWGFDWLYDKLFVKPYLLLCQLLGRDPIDRTLGVVPFSVRGGHNLLSLTENGRLRWYAASLVGGAAILLGALLLA |
| References |
| External Links: |
|
| General Reference: |
PaperBLAST - Find papers about PA2647 and its homologs
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