Identification
Name: NADH-quinone oxidoreductase subunit H
Synonyms:
  • NADH dehydrogenase I subunit H
  • NDH-1 subunit H
  • NUO8
Gene Name: nuoH
Enzyme Class:
Biological Properties
General Function: Involved in oxidation-reduction process
Specific Function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
Cellular Location: Cell inner membrane; Multi-pass membrane protein
KEGG Pathways:
KEGG Reactions:
Thumb+AcceptorThumb+Reduced acceptor
Ubiquinol-8 + Acceptor ↔ Ubiquinone-1 + Reduced acceptor
ReactionCard
Thumb+ThumbThumb+Thumb
SMPDB Reactions:
Thumb+5 Thumb+ThumbThumb+Thumb+Thumb
Thumb+4 Thumb+2 Thumb+menaquinone-8 ? Thumb+Thumb+Thumb+Electron+4 Thumb
"a menaquinone"+4 Thumb+Thumb"a menaquinol"+Thumb
"a menaquinone" + 4 Hydrogen ion + NADH → "a menaquinol" + NAD
ReactionCard
4 Thumb+Thumb+"a menaquinone"Thumb+"a menaquinol"
4 Hydrogen ion + NADH + "a menaquinone" → NAD + "a menaquinol"
ReactionCard
PseudoCyc/BioCyc Reactions:
Thumb+AcceptorThumb+Reduced acceptor
Ubiquinol-8 + Acceptor ↔ Ubiquinone-1 + Reduced acceptor
ReactionCard
Thumb+ThumbThumb+Thumb
Thumb+ThumbThumb+Thumb
Thumb+ThumbThumb+Thumb
Thumb+ThumbThumb+Thumb
Thumb+ThumbThumb+Thumb
Thumb+ThumbThumb+Thumb
Thumb+ThumbThumb+Thumb
Thumb+ThumbThumb+Thumb
Thumb+5 Thumb+ThumbThumb+Thumb+Thumb
Thumb+4 Thumb+2 Thumb+menaquinone-8 ? Thumb+Thumb+Thumb+Electron+4 Thumb
Thumb
NADH + an oxidized unknown electron acceptor + H+ = NAD+ + an reduced unknown electron acceptor
ReactionCard
PAMDB110540+PAMDB001633+ETR-QuinonesPAMDB110542+ETR-Quinols
NADH + Hydrogen ion + ETR-Quinones → NAD+ + ETR-Quinols
ReactionCard
PAMDB000610+PAMDB110540+PAMDB001633PAMDB120506+PAMDB110542
Complex Reactions:
Thumb+4 Thumb+ThumbThumb+Thumb+3 Thumb
4 Thumb+Thumb+ThumbThumb+Thumb+3 Thumb
4 Thumb+Menaquinone 8+ThumbThumb+Thumb+3 Thumb
Thumb+ThumbThumb+Thumb
Thumb+ThumbThumb+Thumb
Thumb+ThumbThumb+Thumb
Thumb+ThumbThumb+Thumb
Thumb+ThumbThumb+Thumb
Thumb+ThumbThumb+Thumb
Thumb+ThumbThumb+Thumb
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB0015632-Demethylmenaquinol 8MetaboCard
PAMDB0015642-Demethylmenaquinone 8MetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB000459HydroquinoneMetaboCard
PAMDB001653Menaquinol 8MetaboCard
PAMDB000197NADMetaboCard
PAMDB000398NADHMetaboCard
PAMDB003450QuinoneMetaboCard
PAMDB001968Ubiquinol-1MetaboCard
PAMDB000237Ubiquinol-8MetaboCard
PAMDB001833Ubiquinone-1MetaboCard
PAMDB001700Ubiquinone-8MetaboCard
GO Classification:
Component
cell part
membrane
Process
metabolic process
oxidation reduction
Gene Properties
Locus tag: PA2643
Strand: +
Entrez Gene ID: 882350
Accession: NP_251333.1
GI: 15597839
Sequence start: 2990435
Sequence End: 2991430
Sequence Length: 995
Gene Sequence:
>PA2643
ATGAGTTGGCTGACTCCCGCTCTGGTCACCATCATCCTCACCGTGGTCAAGGCCATCGTGGTGCTGCTCGCCGTGGTCATCTGCGGCGCCCTGCTAAGCTGGGTCGAGCGCCGCCTGCTCGGCCTCTGGCAGGACCGCTACGGCCCCAACCGGGTCGGTCCGTTCGGTGCGTTCCAGCTCGGCGCGGACATGGTCAAGATGTTCTTCAAGGAGGACTGGACCCCGCCGTTCGCCGACAAGATGATCTTCACCCTGGCCCCGGTAATCGCGATGGGCGCCCTGCTCGTCGCCTTCGCCATCGTGCCGATCACCCCCACCTGGGGCGTGGCGGACCTGAACATCGGCATCCTGTTCTTCTTCGCCATGGCCGGCCTGACGGTGTACGCCGTGCTGTTCGCCGGCTGGTCGAGCAACAACAAGTTCGCCCTGCTCGGCAGCCTGCGCGCCTCGGCCCAGACCATCTCCTACGAGGTGTTCCTGGCCCTGTCGCTGATGGGCATCGTCGCCCAGGTCGGCTCGTTCAACATGCGCGACATCGTCCAGTACCAGATCGACAACGTCTGGTTCATCATTCCGCAGTTCTTCGGCTTCTGCACCTTCATCATCGCCGGCGTCGCCGTGACCCACCGTCACCCGTTCGACCAGCCGGAAGCGGAGCAGGAACTGGCGGACGGCTACCACATCGAGTACGCCGGGATGAAATGGGGCATGTTCTTCGTCGGCGAGTACATCGGCATCGTACTGGTCTCGGCGCTGCTGGCGACCCTGTTCTTCGGCGGCTGGCACGGTCCGTTCCTGGACACCCTGCCCTGGCTGTCGTTCTTCTACTTCGCCGCCAAGACCGGCTTCTTCATCATGCTCTTCATCCTGATCCGCGCCTCGCTGCCGCGTCCGCGCTATGACCAGGTGATGGCGTTCAGCTGGAAGGTGTGCCTGCCGCTGACCCTGATCAACCTGCTGGTGACCGGCGCGCTCGTGCTGGCCGCGGCCCAGTAA
Protein Properties
Protein Residues: 331
Protein Molecular Weight: 36.7 kDa
Protein Theoretical pI: 6.93
Hydropathicity (GRAVY score): 0.867
Charge at pH 7 (predicted): -0.14
Protein Sequence:
>PA2643
MSWLTPALVTIILTVVKAIVVLLAVVICGALLSWVERRLLGLWQDRYGPNRVGPFGAFQLGADMVKMFFKEDWTPPFADKMIFTLAPVIAMGALLVAFAIVPITPTWGVADLNIGILFFFAMAGLTVYAVLFAGWSSNNKFALLGSLRASAQTISYEVFLALSLMGIVAQVGSFNMRDIVQYQIDNVWFIIPQFFGFCTFIIAGVAVTHRHPFDQPEAEQELADGYHIEYAGMKWGMFFVGEYIGIVLVSALLATLFFGGWHGPFLDTLPWLSFFYFAAKTGFFIMLFILIRASLPRPRYDQVMAFSWKVCLPLTLINLLVTGALVLAAAQ
References
External Links:
Resource Link
Genome ID: PA2643
Entrez Gene ID: 882350
NCBI Protein ID: 15597839
General Reference: PaperBLAST - Find papers about PA2643 and its homologs