Identification
Name: Succinate dehydrogenase flavoprotein subunit
Synonyms: Not Available
Gene Name: sdhA
Enzyme Class:
Biological Properties
General Function: Involved in electron carrier activity
Specific Function: Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth
Cellular Location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side
KEGG Pathways:
KEGG Reactions:
Thumb+ThumbThumb+Thumb
Thumb+AcceptorThumb+Reduced acceptor
Succinic acid + Acceptor ↔ Fumaric acid + Reduced acceptor
ReactionCard
Thumb+ThumbThumb+Thumb
SMPDB Reactions:
Thumb+ThumbThumb+Thumb
Thumb+ThumbThumb+Thumb
Thumb+ThumbThumb+Thumb
Thumb+ThumbThumb+Thumb
Thumb+ThumbThumb+Thumb
Thumb+ThumbThumb+Thumb
Thumb+ThumbThumb+Thumb
Thumb+ThumbThumb+Ubiquinol 8+Thumb
Thumb+Coenzyme Q9Thumb+Thumb
Thumb+ThumbThumb+Ubiquinol-10+Thumb
Thumb+ThumbUbiquinol-0+Thumb
PseudoCyc/BioCyc Reactions:
PAMDB120026+PAMDB001633PAMDB120011
PAMDB120026+PAMDB110747PAMDB120011+PAMDB110748
Thumb+ThumbThumb+Thumb
Thumb+AcceptorThumb+Reduced acceptor
Succinic acid + Acceptor ↔ Fumaric acid + Reduced acceptor
ReactionCard
Thumb+ThumbThumb+Thumb
Thumb+ThumbThumb+Thumb
Thumb+ThumbThumb+Thumb
Thumb+ThumbThumb+Thumb
Thumb+ThumbThumb+Thumb
Thumb+ThumbThumb+Thumb
Thumb+ThumbThumb+Thumb
Thumb+ThumbThumb+Thumb
Thumb+ThumbThumb+Ubiquinol 8+Thumb
Thumb+Coenzyme Q9Thumb+Thumb
Thumb+ThumbThumb+Ubiquinol-10+Thumb
ETR-Quinones+PAMDB110747ETR-Quinols+PAMDB110748
ETR-Quinones + succinate → ETR-Quinols + fumarate
ReactionCard
Complex Reactions:
Thumb+ThumbThumb+Thumb
Thumb+acceptorThumb+reduced acceptor
Succinic acid + acceptor → Fumaric acid + reduced acceptor
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB000308FADMetaboCard
PAMDB000293FADH2MetaboCard
PAMDB000073Fumaric acidMetaboCard
PAMDB000459HydroquinoneMetaboCard
PAMDB003450QuinoneMetaboCard
PAMDB000107Succinic acidMetaboCard
PAMDB001968Ubiquinol-1MetaboCard
PAMDB001417Ubiquinol-10MetaboCard
PAMDB001969Ubiquinol-2MetaboCard
PAMDB001970Ubiquinol-3MetaboCard
PAMDB001971Ubiquinol-4MetaboCard
PAMDB001972Ubiquinol-5MetaboCard
PAMDB001855Ubiquinol-6MetaboCard
PAMDB001973Ubiquinol-7MetaboCard
PAMDB000237Ubiquinol-8MetaboCard
PAMDB001974Ubiquinol-9MetaboCard
PAMDB001302Ubiquinone-0MetaboCard
PAMDB001833Ubiquinone-1MetaboCard
PAMDB000242Ubiquinone-10MetaboCard
PAMDB001975Ubiquinone-2MetaboCard
PAMDB001976Ubiquinone-3MetaboCard
PAMDB004125Ubiquinone-4MetaboCard
PAMDB004124Ubiquinone-5MetaboCard
PAMDB001418Ubiquinone-6MetaboCard
PAMDB001978Ubiquinone-7MetaboCard
PAMDB001700Ubiquinone-8MetaboCard
GO Classification:
Function
adenyl nucleotide binding
binding
catalytic activity
electron carrier activity
FAD or FADH2 binding
nucleoside binding
oxidoreductase activity
oxidoreductase activity, acting on the CH-CH group of donors
purine nucleoside binding
Process
acetyl-CoA catabolic process
acetyl-CoA metabolic process
cellular metabolic process
coenzyme metabolic process
cofactor metabolic process
electron transport chain
generation of precursor metabolites and energy
metabolic process
oxidation reduction
tricarboxylic acid cycle
Gene Properties
Locus tag: PA1583
Strand: +
Entrez Gene ID: 881934
Accession: NP_250274.1
GI: 15596780
Sequence start: 1721496
Sequence End: 1723268
Sequence Length: 1772
Gene Sequence:
>PA1583
ATGGCTAGCATTCGTACACTTTCCTTTGACGCCATCATCGTCGGTGGCGGTGGCGCCGGCATGCGTGCCGCGCTGCAACTGGCCCAGGGCGGCCACAAGACCGCCGTGGTGACCAAGGTCTTCCCGACCCGTTCCCACACCGTATCCGCACAGGGTGGCATCACCTGCGCGATCGCTTCGGCCGACCCGAACGACGATTGGCGTTGGCACATGTACGACACCGTCAAGGGTTCCGACTACATCGGTGACCAGGACGCGATCGAATACATGTGTTCCGTCGGTCCCGAGGCCGTGTTCGAGCTCGAGCACATGGGCCTGCCGTTCTCCCGTACCGAAACCGGCCGCATCTACCAGCGTCCGTTCGGCGGCCAGTCCAAGGACTTCGGCAAGGGTGGCCAGGCCGCCCGTACCTGCGCCGCCGCCGACCGTACCGGCCACGCGCTGCTGCACACCCTGTACCAGGCCAACCTGAAGAATGGCACCTCGTTCCTCAACGAGTGGTACGCGGTCGACCTGGTGAAGAACCAGGACGGCGCGGTGGTCGGCATCATCGCCATCTGCATCGAGACCGGCGAGACCGTCTACATCCGTTCCAAGGCCGTGGTCCTGGCCACTGGTGGTGCCGGCCGTATCTACGCCTCCACCACCAACGCGCTGATCAACACCGGTGACGGCGTGGGCATGGCCCTGCGTGCCGGCGTGCCGGTGCAGGACATCGAGATGTGGCAGTTCCACCCGACCGGCATCGCCGGCGCCGGTGTACTGGTCACCGAAGGTTGCCGCGGCGAAGGCGGTTACCTGATCAACGCCCACGGCGAGCGCTTCATGGAGCGTTATGCGCCGAACGCGAAGGACCTGGCCGGTCGCGACGTGGTCGCCCGTTCCATGGTCAAGGAAGTTCTGGCCGGCAACGGCGTGGGTCCGAACAAGGACCACGTGCTGCTGAAACTCGACCACCTCGGCGAGGAAGTCCTGCACAGCCGTCTGCCCGGCATCTGCGAGCTGTCCAAGACCTTCGCCCACGTCGACCCGGTCGTTGCGCCGATCCCGGTGATCCCGACCTGCCACTACATGATGGGCGGCGTTGCCACCAACATCCATGGCCAGGCCATCACCCAGGACGCCAACGGCAACGACCAGATCGTCGAAGGCCTGTTCGCCGTGGGCGAAGTGGCCTGCGTATCGGTACACGGCGCCAACCGCCTGGGCGGCAACTCGCTGCTCGACCTGGTGGTATTCGGCCGTGCCGCCGGTCTGCACCTGGAAAAAGCGCTGAAAGAGGGCATCGACGCCCGCGGCGCTTCCGAGAGCGACCTGGAAGCCTCCTTCAAGCGCCTGAACGGCGTGAACGAGCGCACCAGCGGCGAAGAAGTCGCTCCGCTCAAGCGCGAGCTGCAAAGCTGCATGCAGAACTACTTCGGTGTGTTCCGCACCGGCGAGTACATGCAGAAGGGCATCGCCCAGCTGGCCGACCTGCGCGAGCGTATCGCCAACGTCAAGATCAACGACAAGAGCCAGGCATTCAACACCGCGCGCATCGAAGCGCTGGAACTGCAAAACCTCCTCGAGGTGGCCGAGGCCACCGCGATCGCGGCCGAGCACCGCAAGGAGTCCCGTGGCGCCCACGCCCGTGAAGACTTCGAGGAGCGCGACGACGAGAACTGGCTGTGCCACACCCTGTACTTCCCGGGTGAGAAGCGCGTATCCAAGCGTTCCGTCAACTTCGCGCCGAAGACCGTTCCGGCATTCGAACCCAAGGTTCGGACTTACTAA
Protein Properties
Protein Residues: 590
Protein Molecular Weight: 63.5 kDa
Protein Theoretical pI: 6.47
Hydropathicity (GRAVY score): -0.18
Charge at pH 7 (predicted): -5.71
Protein Sequence:
>PA1583
MASIRTLSFDAIIVGGGGAGMRAALQLAQGGHKTAVVTKVFPTRSHTVSAQGGITCAIASADPNDDWRWHMYDTVKGSDYIGDQDAIEYMCSVGPEAVFELEHMGLPFSRTETGRIYQRPFGGQSKDFGKGGQAARTCAAADRTGHALLHTLYQANLKNGTSFLNEWYAVDLVKNQDGAVVGIIAICIETGETVYIRSKAVVLATGGAGRIYASTTNALINTGDGVGMALRAGVPVQDIEMWQFHPTGIAGAGVLVTEGCRGEGGYLINAHGERFMERYAPNAKDLAGRDVVARSMVKEVLAGNGVGPNKDHVLLKLDHLGEEVLHSRLPGICELSKTFAHVDPVVAPIPVIPTCHYMMGGVATNIHGQAITQDANGNDQIVEGLFAVGEVACVSVHGANRLGGNSLLDLVVFGRAAGLHLEKALKEGIDARGASESDLEASFKRLNGVNERTSGEEVAPLKRELQSCMQNYFGVFRTGEYMQKGIAQLADLRERIANVKINDKSQAFNTARIEALELQNLLEVAEATAIAAEHRKESRGAHAREDFEERDDENWLCHTLYFPGEKRVSKRSVNFAPKTVPAFEPKVRTY
References
External Links:
Resource Link
Genome ID: PA1583
Entrez Gene ID: 881934
NCBI Protein ID: 15596780
General Reference: PaperBLAST - Find papers about PA1583 and its homologs