3-demethylubiquinone-9 3-methyltransferase (PA3171)

Identification
Name: 3-demethylubiquinone-9 3-methyltransferase
Synonyms:
  • 3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase
  • DHHB methyltransferase
Gene Name: ubiG
Enzyme Class:
Biological Properties
General Function: Involved in 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity
Specific Function: S-adenosyl-L-methionine + 3- demethylubiquinone-9 = S-adenosyl-L-homocysteine + ubiquinone-9
Cellular Location: Not Available
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb → Thumb+Thumb+Thumb
2-Octaprenyl-6-hydroxyphenol + S-Adenosylmethionine → 2-Octaprenyl-6-methoxyphenol + S-Adenosylhomocysteine + Hydrogen ion
ReactionCard
Thumb+Thumb ↔ Thumb+Thumb
2-Octaprenyl-6-hydroxyphenol + S-Adenosylmethionine ↔ 2-Octaprenyl-6-methoxyphenol + S-Adenosylhomocysteine
ReactionCard
2-Polyprenyl-6-hydroxyphenol+Thumb ↔ 2-Polyprenyl-6-methoxyphenol+Thumb
2-Polyprenyl-6-hydroxyphenol + S-Adenosylmethionine ↔ 2-Polyprenyl-6-methoxyphenol + S-Adenosylhomocysteine
ReactionCard
2-Polyprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone+Thumb ↔ Thumb+Thumb
2-Polyprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone + S-Adenosylmethionine ↔ Ubiquinone-1 + S-Adenosylhomocysteine
ReactionCard
Thumb+Thumb → Thumb+Thumb+Thumb
2-Octaprenyl-6-hydroxyphenol + S-Adenosylmethionine → Hydrogen ion + 2-Octaprenyl-6-methoxyphenol + S-Adenosylhomocysteine
ReactionCard
SMPDB Reactions:
2-Octaprenyl-6-hydroxyphenol+S-adenosyl-L-methionine+Thumb → Thumb+Thumb+Thumb
2-Octaprenyl-6-hydroxyphenol + S-adenosyl-L-methionine + 2-Octaprenyl-6-hydroxyphenol → Hydrogen ion + S-Adenosylhomocysteine + 2-methoxy-6-(all-trans-octaprenyl)phenol
ReactionCard
Thumb+S-adenosyl-L-methionine → Thumb+Thumb+Ubiquinol 8+Thumb
3-demethylubiquinol-8 + S-adenosyl-L-methionine → Hydrogen ion + S-Adenosylhomocysteine + Ubiquinol 8 + Ubiquinol-8
ReactionCard
2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone+S-adenosyl-L-methionine → Thumb+Thumb+Thumb
2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine → S-Adenosylhomocysteine + Ubiquinol-8 + Hydrogen ion
ReactionCard
PseudoCyc/BioCyc Reactions:
Thumb+Thumb → Thumb+Thumb+Thumb
2-Octaprenyl-6-hydroxyphenol + S-Adenosylmethionine → 2-Octaprenyl-6-methoxyphenol + S-Adenosylhomocysteine + Hydrogen ion
ReactionCard
Thumb+Thumb → Thumb+Thumb+Thumb
2-Octaprenyl-6-hydroxyphenol + S-Adenosylmethionine → Hydrogen ion + 2-Octaprenyl-6-methoxyphenol + S-Adenosylhomocysteine
ReactionCard
Complex Reactions:
Thumb+Thumb → Thumb+Thumb+Thumb
2-Octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol + S-Adenosylmethionine → S-Adenosylhomocysteine + Hydrogen ion + Ubiquinol-8
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB0038272-methoxy-6-(all-trans-octaprenyl)phenolMetaboCard
2-Octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinolMetaboCard
PAMDB0006192-Octaprenyl-6-hydroxyphenolMetaboCard
PAMDB0006212-Octaprenyl-6-methoxyphenolMetaboCard
PAMDB0063763-demethylubiquinol-8MetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB000205S-AdenosylhomocysteineMetaboCard
PAMDB000289S-AdenosylmethionineMetaboCard
PAMDB001973Ubiquinol-7MetaboCard
PAMDB000237Ubiquinol-8MetaboCard
PAMDB001974Ubiquinol-9MetaboCard
PAMDB001833Ubiquinone-1MetaboCard
PAMDB001975Ubiquinone-2MetaboCard
PAMDB001418Ubiquinone-6MetaboCard
PAMDB001978Ubiquinone-7MetaboCard
PAMDB001700Ubiquinone-8MetaboCard
PAMDB001977Ubiquinone-9MetaboCard
GO Classification:
Function
2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity
C-methyltransferase activity
catalytic activity
methyltransferase activity
quinone cofactor methyltransferase activity
transferase activity
transferase activity, transferring one-carbon groups
Process
cellular metabolic process
coenzyme metabolic process
cofactor metabolic process
metabolic process
oxidoreduction coenzyme metabolic process
ubiquinone biosynthetic process
ubiquinone metabolic process
Gene Properties
Locus tag: PA3171
Strand: +
Entrez Gene ID: 882673
Accession: NP_251861.1
GI: 15598367
Sequence start: 3562106
Sequence End: 3562804
Sequence Length: 698
Gene Sequence: 
>PA3171
ATGAGCAACGTCGACCACGCCGAGATCGCCAAATTCGAGGCACTGGCCCATCGCTGGTGGGACCGCGAGAGCGAGTTCAAGCCGCTCCACGACATCAACCCGCTGCGCGTCAACTGGATCGACGAGCGCGCCGGCCTGGCCGGCAAGAAGGTGCTCGACATCGGTTGCGGCGGCGGCATCCTCAGCGAAGCCATGGCCCAGCGCGGCGCCAGCGTCACCGGCATCGACATGGGCGAAGCGCCGCTCGCGGTGGCGCGCCTGCACCAGCTGGAATCCGGCGTCGCCGTCGACTACCGGCAGATCACCGCCGAGCAGATGGCCGAGGAAATGCCCGGGCAATTCGACGTGGTCACCTGCCTGGAGATGCTCGAACACGTGCCGGACCCGGCCTCGGTGATCCGCGCCTGCCACCGCCTGGTCAAGCCGGGCGGACAGGTATTCCTCTCGACCATCAACCGCAATCCCAAGGCCTACCTGTTCGCGGTGATCGGCGCGGAATACATCCTCCAGTTGCTGCCGCGCGGGACCCACGATTTCCGCAAGTTCATTCGTCCGTCGGAACTCGGCGCCTGGTCGCGCGAGGCCGGTCTCGAGGTCAAGGACATCATCGGCCTGACCTACAACCCGCTGACCAAGCACTACAAGCTGGCCAACGACGTCGACGTCAACTACATGGTCCAGACCAAGCGGGAGGCGTGA
Protein Properties
Protein Residues: 232
Protein Molecular Weight: 25.9 kDa
Protein Theoretical pI: 6.31
Hydropathicity (GRAVY score): -0.188
Charge at pH 7 (predicted): -3.17
Protein Sequence: 
>PA3171
MSNVDHAEIAKFEALAHRWWDRESEFKPLHDINPLRVNWIDERAGLAGKKVLDIGCGGGILSEAMAQRGASVTGIDMGEAPLAVARLHQLESGVAVDYRQITAEQMAEEMPGQFDVVTCLEMLEHVPDPASVIRACHRLVKPGGQVFLSTINRNPKAYLFAVIGAEYILQLLPRGTHDFRKFIRPSELGAWSREAGLEVKDIIGLTYNPLTKHYKLANDVDVNYMVQTKREA
References
External Links:
Resource Link
Genome ID: PA3171
Entrez Gene ID: 882673
NCBI Protein ID: 15598367
General Reference: PaperBLAST - Find papers about PA3171 and its homologs