Ubiquinol oxidase subunit 1 (PA1318)

Identification
Name: Ubiquinol oxidase subunit 1
Synonyms:
  • Cytochrome o subunit 1
  • Cytochrome o ubiquinol oxidase subunit 1
  • Oxidase BO(3) subunit 1
  • Ubiquinol oxidase chain A
  • Ubiquinol oxidase polypeptide I
Gene Name: cyoB
Enzyme Class: Not Available
Biological Properties
General Function: Involved in cytochrome-c oxidase activity
Specific Function: Cytochrome o terminal oxidase complex is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high aeration. This ubiquinol oxidase shows proton pump activity across the membrane in addition to the electron transfer
Cellular Location: Cell inner membrane; Multi-pass membrane protein
KEGG Pathways:
  • Oxidative phosphorylation PW000919
  • succinate to cytochrome bo oxidase electron transfer PWY0-1329
  • proline to cytochrome bo oxidase electron transfer PWY0-1544
  • NADH to cytochrome bo oxidase electron transfer PWY0-1335
    KEGG Reactions: Not Available
    SMPDB Reactions:
    Thumb+8 Thumb+2 Thumb → 2 Thumb+8 Thumb+2 Thumb
    Oxygen + 8 Hydrogen ion + 2 Ubiquinol-1 → 2 Water + 8 Hydrogen ion + 2 Ubiquinone-1
    ReactionCard
    PseudoCyc/BioCyc Reactions:
    Thumb+Thumb → Thumb+Thumb
    Ubiquinol-8 + Oxygen → Ubiquinone-8 + Water
    ReactionCard
    Thumb+Thumb → Thumb+Thumb
    Ubiquinol-8 + Oxygen → Ubiquinone-8 + Water
    ReactionCard
    Thumb+8 Thumb+2 Thumb → 2 Thumb+8 Thumb+2 Thumb
    Oxygen + 8 Hydrogen ion + 2 Ubiquinol-1 → 2 Water + 8 Hydrogen ion + 2 Ubiquinone-1
    ReactionCard
    Thumb
    ubiquinol-8 + oxygen = ubiquinone-8 + H2O
    ReactionCard
    PAMDB001633+PAMDB000624+Ubiquinols → PAMDB000142+Ubiquinones+PAMDB001633
    Hydrogen ion + Oxygen + Ubiquinols → Water + Ubiquinones + Hydrogen ion
    ReactionCard
    Complex Reactions:
    2 Thumb+0.5 Thumb+Thumb → Thumb+Thumb+2 Thumb
    2 Hydrogen ion + 0.5 Oxygen + Ubiquinol-8 → Water + Ubiquinone-8 + 2 Hydrogen ion
    ReactionCard
    4 Thumb+0.5 Thumb+Thumb → Thumb+Thumb+4 Thumb
    4 Hydrogen ion + 0.5 Oxygen + Ubiquinol-8 → Water + Ubiquinone-8 + 4 Hydrogen ion
    ReactionCard
    Thumb+Thumb → Thumb+Thumb
    Ubiquinol-8 + Oxygen → Ubiquinone-8 + Water
    ReactionCard
    Thumb+Thumb → Thumb+Thumb
    Ubiquinol-8 + Oxygen → Ubiquinone-8 + Water
    ReactionCard
    Transports: Not Available
    Metabolites:
    PAMDB IDNameView
    PAMDB001633Hydrogen ionMetaboCard
    PAMDB000624OxygenMetaboCard
    PAMDB001968Ubiquinol-1MetaboCard
    PAMDB001973Ubiquinol-7MetaboCard
    PAMDB000237Ubiquinol-8MetaboCard
    PAMDB001974Ubiquinol-9MetaboCard
    PAMDB001833Ubiquinone-1MetaboCard
    PAMDB001700Ubiquinone-8MetaboCard
    PAMDB000142WaterMetaboCard
    GO Classification:
    Component
    cell part
    integral to membrane
    intrinsic to membrane
    membrane part
    Function
    binding
    catalytic activity
    cation binding
    electron carrier activity
    heme binding
    ion binding
    iron ion binding
    metal ion binding
    oxidoreductase activity
    oxidoreductase activity, acting on diphenols and related substances as donors
    oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
    transition metal ion binding
    Process
    aerobic respiration
    cellular metabolic process
    cellular respiration
    energy derivation by oxidation of organic compounds
    generation of precursor metabolites and energy
    metabolic process
    oxidation reduction
    Gene Properties
    Locus tag: PA1318
    Strand: +
    Entrez Gene ID: 881481
    Accession: NP_250009.1
    GI: 15596515
    Sequence start: 1429082
    Sequence End: 1431058
    Sequence Length: 1976
    Gene Sequence: 
    >PA1318
ATGTTCGGGAAACTGACACTCTCGGCCGTGCCTTACCACGAGCCCATCGTCATGGTCACACTGGCCGTCGTCGCCCTGCTGGGCCTCGGCGTGGTCGGTGCGATCACCTACTACCGCAAGTGGACCTACCTGTGGACCGAGTGGCTGACCTCGGTCGACCACAAGAAGATCGGCGTGATGTACATCGTCGTCGCCCTGGTCATGCTGGTCCGCGGCTTCGCCGACGCGATCATGATGCGCGGCCAGCTGGCCCTGGCCGAAGGCGCCAACCACGGCTACCTGCCGCCGGAGCACTACGACCAGATCTTCACCGCGCATGGCGTGATCATGATCATCTTCATGGCCATGCCGTTCATGACCGGCCTGATGAACCTGGCCGTGCCGCTGCAGATCGGCGCGCGCGACGTGGCGTTCCCCTTCCTCAACTCGCTGAGCTTCTGGCTGCTCGTGGTCAGCGCCATGCTGGTCAACGTGTCGCTGGGCCTGGGCGAATTCGCCCGTACCGGCTGGGTGGCCTATCCGCCGCTGTCGGAGCTGGCCTATAGCCCCGGGGTAGGGGTGGACTACTACATCTGGGCGCTACAGATATCCGGGATGGGCACGTTGCTCACGGGGATCAACTTCCTGGTCACCGTGTTCAAGATGCGTACCCCGGGCATGAAGCTGATGCAGATGCCGATCTTCACCTGGACCTGCACCTTCGCCAACATCCTGATCGTCGCCTCGTTCCCGATCCTCACCGCTGCGCTGGGCCTGCTGTCGCTCGACCGCTACCTGGACATGCACTTCTTCACCAACGAGCTCGGCGGCAACGCCATGATGTACATCAACCTCTTCTGGGCCTGGGGCCATCCCGAGGTGTACATCCTGATCCTGCCGGCCTTCGGTATCTTCTCCGAGGTCACCGCGACCTTCGCCGGCAAGCGCATGTTCGGCTACAAGTCGATGGTCTGGGCCAGCGCCGCGATCACCTTCCTCGGCTTCACCGTGTGGCTGCACCACTTCTTCACCATGGGTTCGGGCGGTGACGTCAACGGCTTCTTCGGCGTGGCCACCATGCTGATCTCGATCCCCACCGGGGTGAAGCTGTTCAACTGGCTGTTCACCATCTACAAGGGCCGCCTGCGCTTCAGCACGCCGATCCTGTGGACCCTGGGCTTCATGGTGACCTTCACCATCGGCGGCATGACCGGCGTCCTGCTGGCCATCCCGGGCGCGGACTTCCTGCTGCACAACAGCCTGTTCCTGATCGCCCACTTCCACAACACCATCATCGGCGGCGCGGTATTCGGCTACCTGGCCGGCTTCGCCTTCTGGTTCCCGAAAGCGTTCGGCTTCACCCTCGACGAGAAGTGGGGCAAGCGTTCCTTCTGGTGCTGGCTGGTGGGCTTCTACATGGCCTTCATGCCGCTCTACATCCTCGGCTTCATGGGCATGACCCGTCGCCTGAACCACTACGACAACCCGCTGTGGAAGCCCTACCTGGTGGTCGCGTTCTTCGGCGCCGTGCTGATCTTCTGCGGCATCGCCTGCCAACTGATCCAGCTGTTCGTCTCGGTCCGCAACCGCAAGCAACTGGCCGACGTCAATGGCGACCCGTGGGAAGGCCGCACCCTGGAATGGGCCACTTCCTCGCCGCCGCCGTTCTACAACTTCGCCGAGCTGCCGAAGGTACAGGACGTGGATGCCTTCCACGACATGAAGAAGGCCGGCACCGCCTACCGCAAGCTGCCGGCCTACCAGCCGATCCACATGCCGAAGAACACCGCCGCGGGCTTCTCCATCGCCGTGTTCGCCTTCGTCTTCGGCTTCGCCGCCATCTGGCATATCTGGTGGCTCATGGCGGTCGGCTTCGTCGGCATGATCGGCTCCTTCATCGTGCGCAGCTACAACCAGGACGTCGACTACTACGTCCAGCCCGAAGAGATCGAGAAGATCGAAAGCGCCCGTTTCCAGCAACTCGCCAAGCAGGTCTGA
    Protein Properties
    Protein Residues: 658
    Protein Molecular Weight: 73.9 kDa
    Protein Theoretical pI: 9
    Hydropathicity (GRAVY score): 0.602
    Charge at pH 7 (predicted): 9.71
    Protein Sequence: 
    >PA1318
MFGKLTLSAVPYHEPIVMVTLAVVALLGLGVVGAITYYRKWTYLWTEWLTSVDHKKIGVMYIVVALVMLVRGFADAIMMRGQLALAEGANHGYLPPEHYDQIFTAHGVIMIIFMAMPFMTGLMNLAVPLQIGARDVAFPFLNSLSFWLLVVSAMLVNVSLGLGEFARTGWVAYPPLSELAYSPGVGVDYYIWALQISGMGTLLTGINFLVTVFKMRTPGMKLMQMPIFTWTCTFANILIVASFPILTAALGLLSLDRYLDMHFFTNELGGNAMMYINLFWAWGHPEVYILILPAFGIFSEVTATFAGKRMFGYKSMVWASAAITFLGFTVWLHHFFTMGSGGDVNGFFGVATMLISIPTGVKLFNWLFTIYKGRLRFSTPILWTLGFMVTFTIGGMTGVLLAIPGADFLLHNSLFLIAHFHNTIIGGAVFGYLAGFAFWFPKAFGFTLDEKWGKRSFWCWLVGFYMAFMPLYILGFMGMTRRLNHYDNPLWKPYLVVAFFGAVLIFCGIACQLIQLFVSVRNRKQLADVNGDPWEGRTLEWATSSPPPFYNFAELPKVQDVDAFHDMKKAGTAYRKLPAYQPIHMPKNTAAGFSIAVFAFVFGFAAIWHIWWLMAVGFVGMIGSFIVRSYNQDVDYYVQPEEIEKIESARFQQLAKQV
    References
    External Links:
    Resource Link
    Genome ID: PA1318
    Entrez Gene ID: 881481
    NCBI Protein ID: 15596515
    General Reference: PaperBLAST - Find papers about PA1318 and its homologs