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| 3-Methyl-2-oxovaleric acid | + | + | + | → | + | + |
| 3-Methyl-2-oxovaleric acid | + | L-Glutamic acid | + | + | → | + | L-Isoleucine | + |
| + | + | NADPH | + | → | + |
| + | NADPH | + | + | → | + |
| 2-dehydropantoate | + | NADPH | + | + | + | → | + | (R)-pantoate | + |
| + | + | NADPH | + | → | + |
| → | + | 3-Methyl-2-oxovaleric acid | + |
| L-Aspartic acid | + | + | + | + | → | L-Asparagine | + | + | + | L-Glutamic acid | + | Pyrophosphate | + | + |
| L-Aspartic acid | + | + | + | → | L-Asparagine | + | + | Pyrophosphate | + | + |