Acyl-CoA thioesterase 2 (PA3942)

Identification
Name: Acyl-CoA thioesterase 2
Synonyms:
  • Acyl-CoA thioesterase II
  • TEII
Gene Name: tesB
Enzyme Class: Not Available
Biological Properties
General Function: Involved in acyl-CoA hydrolase activity
Specific Function: Can hydrolyze a broad range of acyl-CoA thioesters. Its physiological function is not known
Cellular Location: Cytoplasmic
KEGG Pathways:
KEGG Reactions: Not Available
SMPDB Reactions:
trans-Octadec-2-enoyl-CoA+Thumb+Thumb → Thumb+Thumb+Elaidic acid
trans-Octadec-2-enoyl-CoA + Water + Trans-Octadec-2-enoyl-CoA → Coenzyme A + Hydrogen ion + Elaidic acid
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PseudoCyc/BioCyc Reactions:
Thumb+Thumb → Thumb+Thumb+Thumb
Water + Octanoyl-CoA → Coenzyme A + Hydrogen ion + Caprylic acid
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Thumb+Thumb → Thumb+Thumb+Thumb
Water + Palmityl-CoA → Coenzyme A + Hydrogen ion + Palmitic acid
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Thumb+Thumb → Thumb+Thumb+Thumb
Water + Tetradecanoyl-CoA → Coenzyme A + Hydrogen ion + tetradecanoate (n-C14:0)
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Thumb+Thumb → Thumb+Thumb+Thumb
Water + Hexanoyl-CoA → Coenzyme A + Hydrogen ion + Hexanoate (N-C6:0)
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Thumb+Thumb → Thumb+Thumb+Thumb
Water + (2E)-Tetradecenoyl-CoA → Coenzyme A + Hydrogen ion + Tetradecenoate (N-C14:1)
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Thumb+Thumb → Thumb+Thumb+Thumb
Water + Octadecenoyl-CoA (N-C18:1CoA) → Coenzyme A + Hydrogen ion + Octadecenoate (N-C18:1)
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Thumb+Thumb → Thumb+Thumb+Thumb
Water + Stearoyl-CoA → Coenzyme A + Hydrogen ion + Octadecanoate (N-C18:0)
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Thumb+Thumb → Thumb+Thumb+Thumb
Lauroyl-CoA + Water → Coenzyme A + Dodecanoate (N-C12:0) + Hydrogen ion
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Thumb+Thumb → Thumb+Thumb+Thumb
Decanoyl-CoA (N-C10:0CoA) + Water → Coenzyme A + Decanoate (N-C10:0) + Hydrogen ion
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Thumb
a 2,3,4-saturated fatty acyl CoA + H2O → a 2,3,4-saturated fatty acid + coenzyme A + H+
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trans-Octadec-2-enoyl-CoA+Thumb+Thumb → Thumb+Thumb+Elaidic acid
trans-Octadec-2-enoyl-CoA + Water + Trans-Octadec-2-enoyl-CoA → Coenzyme A + Hydrogen ion + Elaidic acid
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PAMDB120068+PAMDB000142 → PAMDB120150+PAMDB110248+PAMDB001633
eicosapentaenoyl-CoA + Water → eicosapentaenoate + coenzyme A + Hydrogen ion
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PAMDB120563+PAMDB000142 → PAMDB001633+PAMDB120407+PAMDB110248
3-trans,5-cis-tetradecadienoyl-CoA + Water → Hydrogen ion + (3E,5Z)-tetradecadienoate + coenzyme A
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PAMDB120505+PAMDB000142 → PAMDB001633+PAMDB120512+PAMDB110248
palmitoyl-CoA + Water → Hydrogen ion + palmitate + coenzyme A
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PAMDB120141+PAMDB000142 → PAMDB001633+PAMDB120207+PAMDB110248
jasmonoyl-CoA + Water → Hydrogen ion + (+)-7-iso-jasmonate + coenzyme A
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PAMDB120177+PAMDB000142 → PAMDB120015+PAMDB110248+PAMDB001633
dihomo γ-linolenoyl-CoA + Water → di-homo-γ-linolenate + coenzyme A + Hydrogen ion
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ACYL-COA+PAMDB000142 → PAMDB110248+Carboxylates+PAMDB001633
ACYL-COA + Water → coenzyme A + Carboxylates + Hydrogen ion
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PAMDB110390+PAMDB000142 → PAMDB001633+PAMDB001745+PAMDB110248
stearoyl-CoA + Water → Hydrogen ion + Octadecanoate (N-C18:0) + coenzyme A
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Complex Reactions:
Thumb+Thumb → Thumb+Thumb+Thumb
Water + Octanoyl-CoA → Coenzyme A + Hydrogen ion + Caprylic acid
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Thumb+Thumb → Thumb+Thumb+Thumb
Water + Palmityl-CoA → Coenzyme A + Hydrogen ion + Palmitic acid
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Thumb+Thumb → Thumb+Thumb+Thumb
Water + Tetradecanoyl-CoA → Coenzyme A + Hydrogen ion + tetradecanoate (n-C14:0)
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Thumb+Thumb → Thumb+Thumb+Thumb
Water + Hexanoyl-CoA → Coenzyme A + Hydrogen ion + Hexanoate (N-C6:0)
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Thumb+Thumb → Thumb+Thumb+Thumb
Water + (2E)-Tetradecenoyl-CoA → Coenzyme A + Hydrogen ion + Tetradecenoate (N-C14:1)
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Thumb+Thumb → Thumb+Thumb+Thumb
Water + Octadecenoyl-CoA (N-C18:1CoA) → Coenzyme A + Hydrogen ion + Octadecenoate (N-C18:1)
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Thumb+Thumb → Thumb+Thumb+Thumb
Water + Stearoyl-CoA → Coenzyme A + Hydrogen ion + Octadecanoate (N-C18:0)
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Thumb+Thumb → Thumb+Thumb+Thumb
Lauroyl-CoA + Water → Coenzyme A + Dodecanoate (N-C12:0) + Hydrogen ion
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Thumb+Thumb → Thumb+Thumb+Thumb
Decanoyl-CoA (N-C10:0CoA) + Water → Coenzyme A + Decanoate (N-C10:0) + Hydrogen ion
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Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB000541(2E)-Hexadecenoyl-CoAMetaboCard
PAMDB000542(2E)-Tetradecenoyl-CoAMetaboCard
PAMDB000140Caprylic acidMetaboCard
PAMDB000381Coenzyme AMetaboCard
PAMDB001612Decanoate (N-C10:0)MetaboCard
PAMDB000670Decanoyl-CoA (N-C10:0CoA)MetaboCard
PAMDB001617Dodecanoate (N-C12:0)MetaboCard
PAMDB001637Hexanoate (N-C6:0)MetaboCard
PAMDB000467Hexanoyl-CoAMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB000516Lauroyl-CoAMetaboCard
PAMDB001745Octadecanoate (N-C18:0)MetaboCard
PAMDB001746Octadecenoate (N-C18:1)MetaboCard
PAMDB001668Octadecenoyl-CoA (N-C18:1CoA)MetaboCard
PAMDB000241Octanoyl-CoAMetaboCard
PAMDB000091Palmitic acidMetaboCard
PAMDB000343Palmityl-CoAMetaboCard
PAMDB001690Stearoyl-CoAMetaboCard
PAMDB001757tetradecanoate (n-C14:0)MetaboCard
PAMDB000409Tetradecanoyl-CoAMetaboCard
PAMDB001758Tetradecenoate (N-C14:1)MetaboCard
PAMDB001759Trans-Octadec-2-enoyl-CoAMetaboCard
PAMDB000142WaterMetaboCard
GO Classification:
Function
acyl-CoA thioesterase activity
catalytic activity
CoA hydrolase activity
hydrolase activity
hydrolase activity, acting on ester bonds
thiolester hydrolase activity
Process
acyl-CoA metabolic process
cellular metabolic process
coenzyme metabolic process
cofactor metabolic process
metabolic process
Gene Properties
Locus tag: PA3942
Strand: -
Entrez Gene ID: 878836
Accession: NP_252631.1
GI: 15599137
Sequence start: 4419301
Sequence End: 4420170
Sequence Length: 869
Gene Sequence: 
>PA3942
ATGACCCAGATACTGGACAACCTGGTGGCTTTGCTGAGCCTGGAACCCATCGAGGAGAACCTGTTCCGGGGCATGAGCCAGGATCTCGGCTTCCGCCAGCTCTATGGCGGCCAGGTCCTGGGGCAGGCGCTGTCGGCGGCCAGCCAGACGGTGGAGGACGATCGCCACGTACACTCCATGCACGGCTACTTCCTGCGTCCCGGTGACGCCAGCATGCCGGTGGTCTACCAGGTGGACCGGGTGCGCGACGGCGGCAGCTTCAGCACCCGCCGGGTCACCGCGATCCAGAAAGGCCAGCCGATCTTCACCCTGAGCAGCTCCTTCCAGTACGACGAGGAAGGTTTCCACCACCAGATCGAGATGCCCGAGGTGGTTGGCCCGGATAATCTGCCTTCGGAACTGGAGCTGACCCGCCAGCGCGCCGAGCGGATTCCCGAGCGCATCCGCGACAAGCTGCTGTATCCGAAGCCCATCGAGATTCGTCCGGTCACCCAGCACGACCCCTACGACCCGCAGCCCGACGAACCGGTGAAGTACCTCTGGTTCCGTGCCGACGGCAAGCTGCCGGACGTCCCGGCGCTGCACAAGTACCTGCTGGCCTACGCCTCGGACTTCGGTTTCCTTACCACCTCGATGCAGCCCCATGCCGTTTCGGTGTGGCAGAAGACCATGCAGGTCGCCAGCCTCGACCACGCCCTGTGGTTCCACCGCGACCTGCGCGCGGACGAGTGGCTGCTCTACGCCATCGACAGCCCCTGGGCCGGCAACGCACGCGGTTTCGTGCGCGGCAGCATCTTCAACCAGAGCGGCCAGCTGGTCGCCTCGTCGAGCCAGGAAGGCCTGATCCGCAAGCGTGAGGACTGGGCGTGA
Protein Properties
Protein Residues: 289
Protein Molecular Weight: 32.9 kDa
Protein Theoretical pI: 5.78
Hydropathicity (GRAVY score): -0.435
Charge at pH 7 (predicted): -6.59
Protein Sequence: 
>PA3942
MTQILDNLVALLSLEPIEENLFRGMSQDLGFRQLYGGQVLGQALSAASQTVEDDRHVHSMHGYFLRPGDASMPVVYQVDRVRDGGSFSTRRVTAIQKGQPIFTLSSSFQYDEEGFHHQIEMPEVVGPDNLPSELELTRQRAERIPERIRDKLLYPKPIEIRPVTQHDPYDPQPDEPVKYLWFRADGKLPDVPALHKYLLAYASDFGFLTTSMQPHAVSVWQKTMQVASLDHALWFHRDLRADEWLLYAIDSPWAGNARGFVRGSIFNQSGQLVASSSQEGLIRKREDWA
References
External Links:
Resource Link
Genome ID: PA3942
Entrez Gene ID: 878836
NCBI Protein ID: 15599137
General Reference: PaperBLAST - Find papers about PA3942 and its homologs