3-ketoacyl-CoA thiolase (PA3013)

Identification
Name: 3-ketoacyl-CoA thiolase
Synonyms:
  • Acetyl-CoA acyltransferase
  • Beta-ketothiolase
  • Fatty acid oxidation complex subunit beta
Gene Name: fadA
Enzyme Class:
Biological Properties
General Function: Involved in acetyl-CoA C-acyltransferase activity
Specific Function: Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed. Involved in the aerobic and anaerobic degradation of long-chain fatty acids
Cellular Location: Cytoplasm
KEGG Pathways:
KEGG Reactions:
2 Thumb ↔ Thumb+Thumb
2 Acetyl-CoA ↔ Acetoacetyl-CoA + Coenzyme A
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Thumb+Thumb ↔ Thumb+Thumb
Acetyl-CoA + Octanoyl-CoA ↔ 3-Oxodecanoyl-CoA + Coenzyme A
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Thumb+Thumb ↔ Thumb+Thumb
Acetyl-CoA + Tetradecanoyl-CoA ↔ 3-Oxohexadecanoyl-CoA + Coenzyme A
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Thumb+Thumb ↔ Thumb+Thumb
Acetyl-CoA + Hexanoyl-CoA ↔ 3-Oxooctanoyl-CoA + Coenzyme A
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Thumb+Thumb ↔ Thumb+Thumb
Acetyl-CoA + Lauroyl-CoA ↔ 3-Oxotetradecanoyl-CoA + Coenzyme A
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Thumb+Thumb ↔ Thumb+Thumb
Acetyl-CoA + Decanoyl-CoA (N-C10:0CoA) ↔ 3-Oxododecanoyl-CoA + Coenzyme A
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Thumb+Thumb ↔ Thumb+Thumb
Coenzyme A + 3-Oxoadipyl-CoA ↔ Acetyl-CoA + Succinyl-CoA
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Thumb+Thumb ↔ Thumb+Thumb
Succinyl-CoA + Acetyl-CoA ↔ Coenzyme A + 3-Oxoadipyl-CoA
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Thumb+Thumb ↔ Thumb+Thumb
Propionyl-CoA + Acetyl-CoA ↔ Coenzyme A + 2-Methylacetoacetyl-CoA
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Thumb+Butanoyl-CoA ↔ Thumb+Thumb
Acetyl-CoA + Butanoyl-CoA ↔ Coenzyme A + 3-Oxohexanoyl-CoA
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Thumb+Thumb ↔ Thumb+Thumb
Octanoyl-CoA + Acetyl-CoA ↔ Coenzyme A + 3-Oxodecanoyl-CoA
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Thumb+Thumb ↔ Thumb+Thumb
Lauroyl-CoA + Acetyl-CoA ↔ Coenzyme A + 3-Oxotetradecanoyl-CoA
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Thumb+Thumb ↔ Thumb+Thumb
Tetradecanoyl-CoA + Acetyl-CoA ↔ Coenzyme A + 3-Oxohexadecanoyl-CoA
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Thumb+Chenodeoxycholoyl-CoA ↔ Thumb+Thumb
Propionyl-CoA + Chenodeoxycholoyl-CoA ↔ Coenzyme A + 3alpha,7alpha-Dihydroxy-5beta-cholestanoyl-CoA
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Thumb+Thumb ↔ Thumb+Thumb
Decanoyl-CoA (N-C10:0CoA) + Acetyl-CoA ↔ Coenzyme A + 3-Oxododecanoyl-CoA
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Thumb+Thumb ↔ Thumb+Thumb
Hexanoyl-CoA + Acetyl-CoA ↔ Coenzyme A + 3-Oxooctanoyl-CoA
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Thumb+Thumb ↔ Thumb+Thumb
7-Methyl-3-oxo-6-octenoyl-CoA + Coenzyme A ↔ 5-Methylhex-4-enoyl-CoA + Acetyl-CoA
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Thumb+Thumb ↔ Thumb+Thumb
5-Methyl-3-oxo-4-hexenoyl-CoA + Coenzyme A ↔ 3-Methylcrotonyl-CoA + Acetyl-CoA
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Acyl-CoA+Thumb ↔ Thumb+Thumb
Acyl-CoA + Acetyl-CoA ↔ Coenzyme A + 3-Oxoacyl-CoA
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SMPDB Reactions:
3-oxo-opc8-coa → OPC6-CoA
3-oxo-opc8-coa → OPC6-CoA
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3-Oxo-OPC6-CoA → OPC4-CoA
3-Oxo-OPC6-CoA → OPC4-CoA
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3-oxo-opc4-coa → (+)-7-Isojasmonic acid CoA
3-oxo-opc4-coa → (+)-7-Isojasmonic acid CoA
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a 3-oxoacyl-CoA?+Thumb → Thumb+a 2,3,4-saturated fatty acyl CoA?
a 3-oxoacyl-CoA? + Coenzyme A → Acetyl-CoA + a 2,3,4-saturated fatty acyl CoA?
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Acetoacetyl-CoA+Thumb+Thumb → Thumb+Succinyl-CoA+Thumb
Acetoacetyl-CoA + Coenzyme A + Acetoacetyl-CoA → Acetyl-CoA + Succinyl-CoA + Succinyl-CoA
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Thumb+Thumb → Thumb+Thumb
3-Oxodecanoyl-CoA + Coenzyme A → Acetyl-CoA + Lauroyl-CoA
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Thumb+Thumb → Thumb+Octanoyl-CoA+Thumb
3-Oxohexanoyl-CoA + Coenzyme A → Acetyl-CoA + Octanoyl-CoA + Octanoyl-CoA
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Thumb+Thumb → Thumb+Thumb
3-Oxododecanoyl-CoA + Coenzyme A → Acetyl-CoA + Tetradecanoyl-CoA
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Thumb+Thumb → Thumb+Thumb
3-Oxotetradecanoyl-CoA + Coenzyme A → Acetyl-CoA + Palmityl-CoA
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Thumb+Thumb → Thumb+Decanoyl-CoA (n-C10:0CoA)+Thumb
3-Oxooctanoyl-CoA + Coenzyme A → Acetyl-CoA + Decanoyl-CoA (n-C10:0CoA) + Decanoyl-CoA (N-C10:0CoA)
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Thumb+Thumb → Thumb+Stearoyl-CoA+Thumb
3-Oxohexadecanoyl-CoA + Coenzyme A → Acetyl-CoA + Stearoyl-CoA + Stearoyl-CoA
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3-Oxooctadecanoyl-CoA+Thumb+Thumb → Thumb+Stearoyl-CoA+Thumb
3-Oxooctadecanoyl-CoA + Coenzyme A + 3-Oxooctadecanoyl-CoA → Acetyl-CoA + Stearoyl-CoA + Stearoyl-CoA
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PseudoCyc/BioCyc Reactions:
2 Thumb ↔ Thumb+Thumb
2 Acetyl-CoA ↔ Acetoacetyl-CoA + Coenzyme A
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Thumb+Thumb ↔ Thumb+Thumb
Coenzyme A + 3-Oxoadipyl-CoA ↔ Acetyl-CoA + Succinyl-CoA
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Complex Reactions:
Thumb+Thumb ↔ Thumb+Thumb
Acetyl-CoA + Butyryl-CoA ↔ 3-Oxohexanoyl-CoA + Coenzyme A
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Thumb+Thumb ↔ Thumb+Thumb
3-Oxooctadecanoyl-CoA + Coenzyme A ↔ Acetyl-CoA + Palmityl-CoA
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Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB0002772-Methylacetoacetyl-CoAMetaboCard
PAMDB0004013-Methylcrotonyl-CoAMetaboCard
PAMDB0009233-Oxo-OPC4-CoAMetaboCard
PAMDB0009243-Oxo-OPC6-CoAMetaboCard
PAMDB0009263-Oxoadipyl-CoAMetaboCard
PAMDB0005353-Oxodecanoyl-CoAMetaboCard
PAMDB0005333-Oxododecanoyl-CoAMetaboCard
PAMDB0006693-Oxohexadecanoyl-CoAMetaboCard
PAMDB0005393-Oxohexanoyl-CoAMetaboCard
PAMDB0015793-Oxooctadecanoyl-CoAMetaboCard
PAMDB0005373-Oxooctanoyl-CoAMetaboCard
PAMDB0005313-Oxotetradecanoyl-CoAMetaboCard
PAMDB0004433alpha,7alpha-Dihydroxy-5beta-cholestanoyl-CoAMetaboCard
PAMDB0009525-Methyl-3-oxo-4-hexenoyl-CoAMetaboCard
PAMDB0009535-Methylhex-4-enoyl-CoAMetaboCard
PAMDB0009567-Methyl-3-oxo-6-octenoyl-CoAMetaboCard
PAMDB000397Acetoacetyl-CoAMetaboCard
PAMDB000298Acetyl-CoAMetaboCard
PAMDB000968Benzoyl acetyl-CoAMetaboCard
PAMDB000250Butyryl-CoAMetaboCard
PAMDB000381Coenzyme AMetaboCard
PAMDB000670Decanoyl-CoA (N-C10:0CoA)MetaboCard
PAMDB000467Hexanoyl-CoAMetaboCard
PAMDB000516Lauroyl-CoAMetaboCard
PAMDB000241Octanoyl-CoAMetaboCard
PAMDB000343Palmityl-CoAMetaboCard
PAMDB000321Propionyl-CoAMetaboCard
PAMDB001690Stearoyl-CoAMetaboCard
PAMDB000228Succinyl-CoAMetaboCard
PAMDB000409Tetradecanoyl-CoAMetaboCard
GO Classification:
Component
cell part
cytoplasm
intracellular part
Function
acetyl-CoA C-acyltransferase activity
acyltransferase activity
C-acyltransferase activity
catalytic activity
transferase activity
transferase activity, transferring acyl groups
transferase activity, transferring acyl groups other than amino-acyl groups
Process
carboxylic acid metabolic process
cellular metabolic process
fatty acid metabolic process
lipid catabolic process
lipid metabolic process
metabolic process
monocarboxylic acid metabolic process
organic acid metabolic process
oxoacid metabolic process
primary metabolic process
Gene Properties
Locus tag: PA3013
Strand: -
Entrez Gene ID: 880523
Accession: NP_251703.1
GI: 15598209
Sequence start: 3373254
Sequence End: 3374429
Sequence Length: 1175
Gene Sequence: 
>PA3013
ATGAGCCTGAATCCGAGAGACGTCGTCATTGTCGACTTCGGCCGCACCCCGATGGGTCGTTCCAAGGGTGGCATGCACCGCAACACCCGCGCCGAGACCATGTCGGCGCACCTGATCAGCAAGCTGCTGGAGCGCAACCCGAAGGTCGACCCGGCCGAAGTGGAAGACGTGATCTGGGGCTGCGTCAACCAGACCCTGGAGCAGGGCTGGAACATCGCGCGCATGGCGTCGCTGATGACCCAGATCCCGCACACCAGCGCCGCGCAGACCGTCAGCCGCCTGTGCGGTTCGTCGATGAGCGCGCTGCACACCGCCGCCCAGGCGATCCAGACCGGCAATGGCGATGTATTCGTCATCGGCGGCGTGGAGCACATGGGCCACGTCGGCATGATGCATGGCGTCGACCCGAACCCGCACCTGTCCCTGTACGCCGCCAAGGCCTCGGGCATGATGGGCCTGACTGCGGAAATGCTCGGCAAGATGCACGGTATCAGCCGTGAGGCGCAGGACAAGTTCGGCGCGCGTTCGCACCAACTGGCCTGGAAGGCCACCCAGGAAGGCAAGTTCAAGGACGAGATCATCCCGATGGAAGGGTATGACGAGAACGGTTTCCTGAAAGTCTTCGACTTCGACGAGACCATTCGTCCGGAAACCACCGTCGAGACCCTGGCCGAGTTGAAGCCGGCGTTCAATCCGAAAGGCGGCACCGTGACCGCGGGGACCTCCTCGCAGATCACCGACGGTGCCTCCTGCATGATCGTGATGTCGGCCCAGCGCGCCCAGGACCTGGGCATCCAGCCGATGGCGGTGATCCGCTCCATGGCCGTGGCGGGTGTCGACCCGGCTATCATGGGCTACGGCCCGGTGCCGTCGACCAACAAGGCGCTCAAGCGTGCCGGCCTGACCATCGCCGACATCGATTTCGTCGAACTCAACGAAGCCTTCGCCGCCCAGGCCCTGCCTGTGCTGAAGGACCTCAAGCTGCTCGACAAGATGGACGAGAAGGTCAACCTCCACGGCGGCGCCATCGCCCTGGGTCACCCGTTCGGTTGCTCCGGTGCGCGCATTTCCGGCACCCTGTTGAACGTGATGAAGCAGAACGGCGGTACCCTTGGCGTGTCCACCATGTGCGTGGGCCTGGGACAGGGTATCACCACCGTCTTCGAGCGCATCTAA
Protein Properties
Protein Residues: 391
Protein Molecular Weight: 41.6 kDa
Protein Theoretical pI: 6.79
Hydropathicity (GRAVY score): -0.049
Charge at pH 7 (predicted): -1.26
Protein Sequence: 
>PA3013
MSLNPRDVVIVDFGRTPMGRSKGGMHRNTRAETMSAHLISKLLERNPKVDPAEVEDVIWGCVNQTLEQGWNIARMASLMTQIPHTSAAQTVSRLCGSSMSALHTAAQAIQTGNGDVFVIGGVEHMGHVGMMHGVDPNPHLSLYAAKASGMMGLTAEMLGKMHGISREAQDKFGARSHQLAWKATQEGKFKDEIIPMEGYDENGFLKVFDFDETIRPETTVETLAELKPAFNPKGGTVTAGTSSQITDGASCMIVMSAQRAQDLGIQPMAVIRSMAVAGVDPAIMGYGPVPSTNKALKRAGLTIADIDFVELNEAFAAQALPVLKDLKLLDKMDEKVNLHGGAIALGHPFGCSGARISGTLLNVMKQNGGTLGVSTMCVGLGQGITTVFERI
References
External Links:
Resource Link
Genome ID: PA3013
Entrez Gene ID: 880523
NCBI Protein ID: 15598209
General Reference: PaperBLAST - Find papers about PA3013 and its homologs